Results 51 to 60 of about 1,677,689 (317)

Liver Tumor Prediction with Advanced Attention Mechanisms Integrated into a Depth-Based Variant Search Algorithm [PDF]

open access: yes, 2023
In recent days, Deep Learning (DL) techniques have become an emerging transformation in the field of machine learning, artificial intelligence, computer vision, and so on. Subsequently, researchers and industries have been highly endorsed in the medical field, predicting and controlling diverse diseases at specific intervals.
arxiv   +1 more source

Decavanadate displaces inositol 1,4,5-trisphosphate (IP3) from its receptor and inhibits IP3 induced Ca2+ release in permeabilized pancreatic acinar cells [PDF]

open access: yes, 1991
Inositol 1,4,5-trisphosphate (IP3) induced Ca2+ release in digitonin permeabilized rat pancreatic acinar cells is specifically inhibited by decavanadate.
Ammann   +30 more
core   +1 more source

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

open access: yesHepatology, EarlyView., 2022
The role of SMLR1 in lipid metabolism (high fat + cholesterol diet in mice) Abstract Background and Aims The assembly and secretion of VLDL from the liver, a pathway that affects hepatic and plasma lipids, remains incompletely understood. We set out to identify players in the VLDL biogenesis pathway by identifying genes that are co‐expressed with the ...
Willemien van Zwol   +22 more
wiley   +1 more source

The metabolism of gelsevirine in human, pig, goat and rat liver microsomes

open access: yesVeterinary Medicine and Science, 2021
Gelsemium is a small genus of flowering plants from the family Loganiaceae comprising five species, three of which, Gelsemium sempervirens (L.) J. St.‐Hil., G. elegans Benth and G. rankinii Small, are particularly popular.
Hua‐Hai Zhang   +5 more
doaj   +1 more source

Metabolism of profenofos to 4-bromo-2-chlorophenol, a specific and sensitive exposure biomarker. [PDF]

open access: yes, 2013
Profenofos is a direct acting phosphorothioate organophosphorus (OP) pesticide capable of inhibiting β-esterases such as acetylcholinesterase, butyrylcholinesterase, and carboxylesterase.
Chi, Lai-Har   +8 more
core   +1 more source

Nontargeted Metabolomics by High-Resolution Mass Spectrometry to Study the In Vitro Metabolism of a Dual Inverse Agonist of Estrogen-Related Receptors β and γ, DN203368

open access: yesPharmaceutics, 2021
DN203368 ((E)-3-[1-(4-[4-isopropylpiperazine-1-yl]phenyl) 3-methyl-2-phenylbut-1-en-1-yl] phenol) is a 4-hydroxy tamoxifen analog that is a dual inverse agonist of estrogen-related receptor β/γ (ERRβ/γ).
Sin-Eun Kim   +13 more
doaj   +1 more source

Improvement of the solubilization of proteins in two-dimensional electrophoresis with immobilized pH gradients [PDF]

open access: yesElectrophoresis 18 (31/03/1997) 307-16, 2006
Membrane and nuclear proteins of poor solubility have been separated by high resolution two-dimensional (2-D) gel electrophoresis. Isoelectric focusing with immobilized pH gradients leads to severe quantitative losses of proteins in the resulting 2-D map, although the resolution is usually high.
arxiv   +1 more source

Realistic Ultrasound Image Synthesis for Improved Classification of Liver Disease [PDF]

open access: yes, 2021
With the success of deep learning-based methods applied in medical image analysis, convolutional neural networks (CNNs) have been investigated for classifying liver disease from ultrasound (US) data. However, the scarcity of available large-scale labeled US data has hindered the success of CNNs for classifying liver disease from US data.
arxiv   +1 more source

Metabolism of (+)- and (-)-menthols by CYP2A6 in human liver microsomes.

open access: yesJournal of Oleo Science, 2011
The in vitro metabolism of (+)-(1S,3S,4R) and (-)-(1R,3R,4S)-menthol enantiomers was examined by incubation with human liver microsomes, and the oxidative metabolites thus formed were analyzed using gas chromatography-mass spectrometry (GC-MS).
M. Miyazawa   +5 more
semanticscholar   +1 more source

CYP-Dependent Metabolism of PF9601N, A New Monoamine Oxidase-B Inhibitor, by C57BL / 6 Mouse and Human Liver Microsomes

open access: yesJournal of Pharmacy & Pharmaceutical Sciences, 2007
Purpose. The selective monoamine oxidase-B (MAO-B) inhibitor, l-deprenyl, is still used for treating Parkinson's patients, however, a disadvantage of its use lies in the formation of l-amphetamine and l-methamphetamine.
Stefania Dragoni   +7 more
doaj   +1 more source

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