Results 101 to 110 of about 81,174 (219)

Manipulation of Chemistry and Biology with Visible Light Using Tetra‐ortho‐Substituted Azobenzenes and Azonium Ions

Angewandte Chemie, Volume 137, Issue 24, June 10, 2025.
Tetra‐ortho‐Azobenzenes (TOABs) in broad daylight: in recent years, TOAB photoswitches became indispensable tools for all‐visible‐light manipulation of chemistry, biology and materials. This review explores their unique photochemical properties, design and synthetic approaches, offering support in choosing a TOAB for a given application.
Francesca Cardano, Rosa Márquez García, Wiktor Szymanski   +2 more
wiley   +2 more sources

An adamantane‐based ligand as a novel chemical tool for thermosensory TRPM8 channel therapeutic modulation

The FEBS Journal, EarlyView.
Transient receptor potential cation channel subfamily M member 8 (TRPM8) is a cationic thermosensory channel crucial for cold sensation and menthol response. TRPM8 dysfunction leads to sensory symptoms such as cold allodynia. Targeting TRPM8 is important for treating diseases like peripheral neuropathies and cancer.
Angela Lamberti, Silvio Aprile, David Cabañero, Fabio Travagin, Laura Butron, Gregorio Fernández‐Ballester, Gian Cesare Tron, Asia Fernández‐Carvajal, Antonio Ferrer‐Montiel, Ubaldina Galli   +9 more
wiley   +1 more source

Stereochemical insights into sarpagan and akuammiline alkaloid biosynthesis

New Phytologist, EarlyView.
Summary Sarpagan and akuammiline monoterpenoid indole alkaloids (MIAs) are a class of bioactive plant‐derived compounds with significant pharmaceutical potential. These alkaloids are formed through oxidative cyclization of geissoschizine, catalyzed by homologous cytochrome P450 monooxygenases (CYP) known as sarpagan bridge enzymes (SBEs) and rhazimal ...
Scott Galeung Alexander Mann, Melina Paz‐Galeano, Mohammadamin Shahsavarani, Jacob Owen Perley, Jun Guo, Jorge Jonathan Oswaldo Garza‐Garcia, Yang Qu   +6 more
wiley   +1 more source

Oxidative Rearrangements of the Alkaloid Intermediate Geissoschizine

Angewandte Chemie, Volume 137, Issue 24, June 10, 2025.
19E‐geissoschizine is a key precursor in the biosynthesis of monoterpene indole alkaloids such as strychnine, ibogaine, and vinblastine. Using enzymatic assays and gene silencing, three CYPs were identified from C. roseus that oxidize this compound to four alkaloid scaffolds: strychnos, sarpagan, akuammiline, and mavacurane. Mutational analysis reveals
Mohamed O. Kamileen, Benke Hong, Klaus Gase, Maritta Kunert, Lorenzo Caputi, Benjamin R. Lichman, Sarah E. O'Connor   +6 more
wiley   +2 more sources

The ins and outs of liver fat metabolism: The effect of phenotype and diet on risk of intrahepatic triglyceride accumulation

Experimental Physiology, EarlyView.
Abstract In health, the liver is a metabolically flexible organ that plays a key role in regulating systemic lipid and glucose concentrations. There is a constant flux of fatty acids (FAs) to the liver from multiple sources, including adipose tissue, dietary, endogenously synthesized from non‐lipid precursors, intrahepatic lipid droplets and recycling ...
Kieran Smith, Kaitlyn M. J. H. Dennis, Leanne Hodson   +2 more
wiley   +1 more source

The X‐Linked Intellectual Disability Gene, ZDHHC9 , Is Important for Oligodendrocyte Subtype Determination and Myelination

Glia, Volume 73, Issue 7, Page 1452-1466, July 2025.
Main Points Zdhhc9 ablation grossly changes gene expression and myelin protein levels in CNS WM. Zdhhc9 is important for the establishment of mature oligodendrocyte subtypes. Zdhhc9 is important for axon myelination and the maintenance of myelin integrity.
Rocio B. White, Angela R. Wild, Timothy P. O'Leary, Andrew J. Thompson, Stephane Flibotte, Angie Peng, Jason C. Rogalski, Mila Mair, Neeki Derhami, Shernaz X. Bamji   +9 more
wiley   +1 more source

Beyond-Rule-of-Five Compounds Are Not Different: In Vitro-In Vivo Extrapolation of Female CD-1 Mouse Clearance Based on Merck Healthcare KGaA Compound Set. [PDF]

Pharmaceuticals (Basel)
Maurer CK, Fang Z, Duevel HM, Harlfinger S, Petersson C.   +4 more
europepmc   +1 more source

Liver‐Directed Gene Therapy Mitigates Early Nephropathy in Murine Glycogen Storage Disease Type Ia

Journal of Inherited Metabolic Disease, Volume 48, Issue 4, July 2025.
ABSTRACT Nephropathy is a complication of glycogen storage disease type Ia (GSD‐Ia), a metabolic disorder caused by pathogenic variants in glucose‐6‐phosphatase‐α (G6Pase‐α or G6PC1). While maintaining blood glucose homeostasis can delay the progression of renal disease in GSD‐Ia, the benefits of liver‐directed G6PC1 gene therapy on nephropathy remain ...
Cheol Lee, Kunal Pratap, Lisa Zhang, Hung Dar Chen, Irina Arnaoutova, Matthew F. Starost, Brian C. Mansfield, Janice Y. Chou   +7 more
wiley   +1 more source

Effects of mallotus furetianus extract on CYP3A activities in rats. [PDF]

Sci Rep
Huang W, Kim HI, Cao F, Li S, Park J, Li P.   +5 more
europepmc   +1 more source

Strategy‐Level Prodrug Synthesis

Chemistry – A European Journal, Volume 31, Issue 33, June 12, 2025.
Prodrug approaches can be expanded by increasing options for controlling site‐selective functionalization, boosting the range of linking groups, and enhancing the chemoselectivity of reactive group incorporation. This Concept describes strategy‐level prodrug synthesis, whereby these issues are addressed at an early stage of a sequence.
Paul J. Geaneotes, Paul E. Floreancig
wiley   +1 more source