Results 181 to 190 of about 97,218 (302)

Evaluation of in vitro drug-drug interactions of ivermectin and antimalarial compounds. [PDF]

Malar J
Tipthara P, Kullasakboonsri R, Kobylinski KC, Tarning J.   +3 more
europepmc   +1 more source

The effect of phenobarbitone on the incorporation of delta-aminolaevulinic acid into rat liver microsomes [PDF]

, 1969
R. Colin Garner, A.E.M. McLean
openalex   +1 more source

Assessing Cytochrome P450 Drug Interaction Risk for Dordaviprone Using Physiologically Based Pharmacokinetic Modeling

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 10, Page 1695-1704, October 2025.
ABSTRACT A physiologically based pharmacokinetic (PBPK) model was developed and verified for dordaviprone, a small molecule with antitumor effects in glioma patients. The model was applied to assess the drug–drug interaction (DDI) potential of dordaviprone as a victim of CYP3A4 inhibitors and inducers, and as a perpetrator of CYP3A4, CYP2C8, CYP2D6 ...
Swati Jaiswal, Nikunjkumar K. Patel, Hannah M. Jones, Savannah McFeely, Shamia L. Faison, Tim Tippin, Odin Naderer   +6 more
wiley   +1 more source

NAD(P)⁺-dependent alcohol oxidoreductases oxidize 7-hydroxycannabidiol to a reactive formyl metabolite. [PDF]

Arch Toxicol
Wu Q, Fang JL, Nagumalli SK, Guo X, Beland FA.   +4 more
europepmc   +1 more source

The Composition of Liver Vitamin A Ester and the Synthesis of Vitamin A Ester by Liver Microsomes

, 1964
Sidney Futterman, John S. Andrews
openalex   +1 more source

Human in vitro metabolism of an environmental mixture of polycyclic aromatic hydrocarbons (PAH) found at the Portland Harbor Superfund Site. [PDF]

Toxicol Lett
Gaither KA, Tyrrell K, Garcia W, Anderson KA, Smith JN.   +4 more
europepmc   +1 more source

METABOLISM OF DRUGS IN OLD RATS (I) ACTIVITIES OF NADPH-LINKED ELECTRON TRANSPORT AND DRUG-METABOLIZING ENZYME SYSTEMS IN LIVER MICROSOMES OF OLD RATS

, 1968
Ryuichi Kato, Akira Takanaka
openalex   +1 more source

The role of endogenous cations in the Na+-K+-Mg2+-effected adenosine triphosphatase of cerebral microsomes [PDF]

, 1969
Peter S. Goldfarb, Richard Rodnight
openalex   +1 more source

Physiologically Based Pharmacokinetic Modeling of Valemetostat to Inform Dose Recommendations When Coadministered With CYP3A/P‐gp Modulators

Clinical and Translational Science, Volume 18, Issue 10, October 2025.
ABSTRACT Valemetostat tosylate (valemetostat) is an oral, potent, selective dual inhibitor of enhancer of zeste homolog (EZH)2 and EZH1, approved in Japan for the treatment of relapsed/refractory adult T‐cell leukemia/lymphoma and peripheral T‐cell lymphoma.
Akiko Watanabe, Noriko Okudaira, Masaya Tachibana, Miho Kazui, Masakatsu Kotsuma, Takako Shimizu, Yvonne Lau   +6 more
wiley   +1 more source

Protocol for screening inhibitors of the fungal sphingolipid-metabolizing enzyme ceramide synthase. [PDF]

STAR Protoc
Zhong A, Dasilva D, Pereira de Sa N, You JK, Del Poeta M.   +4 more
europepmc   +1 more source