Results 181 to 190 of about 98,869 (304)

Pharmacokinetics, pharmacodynamics, and safety interaction study of tunodafil hydrochloride and alcohol: A randomized, blinded, placebo‐controlled, three‐cycle crossover study in Chinese healthy men

Andrology, Volume 14, Issue 2, Page 466-479, February 2026.
Abstract Objectives This study aimed to evaluate the pharmacodynamic effects of administering tunodafil hydrochloride with alcohol on blood pressure and heart rate in healthy Chinese males, and to investigate the mutual pharmacokinetic interactions and safety of the combination.
Dingyuan Hu, Suping Niu, Fan Huang, Lu Jin, Qun Gu, Yanting Li, Chongyou Lee, Zhenwei Xie, Xiangxing Liu, Fang Men, Wenyan Zhao, Shuang Li, Yian Liu, Qian Wang, Huaying Fan, Jiaojiao Zhang, Shuangshuang Lin, Liming Chen, Yi Fang   +18 more
wiley   +1 more source

Investigating the potential role of metabolic resistance genes in conferring cross-resistance to pyrethroids and polycyclic aromatic hydrocarbon pollutants in the major malaria vector Anopheles coluzzii. [PDF]

BMC Genomics
Muhammad A, Ibrahim SS, Ismail HM, Irving H, Paine MJI, Wondji CS.   +5 more
europepmc   +1 more source

Antiseizure Effects of Cannabidiol in Combination With Cannabigerol in the Maximal Electroshock Seizure Model

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 2, February 2026.
Cannabidiol and cannabigerol suppress maximal electroshock seizures. Cannabidiol and cannabigerol show similar dose–response properties. Both cannabinoids show no toxicity at effective doses. ABSTRACT Current antiseizure therapy for epilepsy is only effective in about 70% of the patient population.
Han Zhong Zhou, Brian Wayne Scott, Yagoda Izabela Oleksak, Willets McIntyre Burnham   +3 more
wiley   +1 more source

Evaluation of Pyrrole Heterocyclic Derivatives as Selective MAO-B Inhibitors and Neuroprotectors. [PDF]

Molecules
Georgieva M, Sharkov M, Mateev E, Mateeva A, Kondeva-Burdina M.   +4 more
europepmc   +1 more source

Identification of di-2-ethylhexyl terephthalate (DEHTP) metabolites using human liver microsomes for biomonitoring applications

, 2015
Manori J. Silva, Ella Samandar, Antonia M. Calafat, Xiaoyun Ye   +3 more
openalex   +1 more source

Opportunities of patient‐derived organoids in drug development

British Journal of Pharmacology, Volume 183, Issue 4, Page 939-944, February 2026.
Various model systems are utilised during drug development starting from basic research, moving to preclinical research and development for clinical applications in order to identify new drugs to improve human health. However, there are characteristics of humans that are not captured by established models.
Antonia Büning, Elena Reckzeh
wiley   +1 more source

Metabolism of the Isoflavone Derivative Structural Isomers ACF-02 and ACF-03 in Human Liver Microsomes. [PDF]

Pharmaceutics
Liang Z, Kim EH, Kim GY, Choi JH, Seo HJ, Liu KH, Cho M.   +6 more
europepmc   +1 more source

The participation of sterol carrier protein2 in the conversion of cholesterol to cholesterol ester by rat liver microsomes.

, 1981
K.L. Gavey, B.J. Noland, T J Scallen
openalex   +1 more source

Mutagenicity of two species of the genus Alchornea measured by Salmonella microsome assay and micronucleus test [PDF]

, 2010
Fábio Vieira dos Santos, Tamara Regina Calvo, Ilce Mara S. Cólus, Wagner Vilegas, Eliana Aparecida Varanda   +4 more
openalex   +1 more source

Autoimmune Hepatitis: Histopathological Diversity and Its Clinical Implications

Hepatology Research, Volume 56, Issue 2, Page 139-147, February 2026.
ABSTRACT Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease characterized by diverse clinical and histological manifestations. Accurate histopathological evaluation plays a critical role in determining disease activity, guiding treatment strategies, and predicting prognosis.
Mina Komuta, Kenichi Harada
wiley   +1 more source