Results 11 to 20 of about 47,963 (298)
Oxidative decarboxylation of retinoic acid in microsomes of rat liver and kidney
Journal of Lipid Research, 1968 Liver and kidney microsomes have been found to catalyze a rapid decarboxylation of retinoic acid in vitro. The reaction requires NADPH and Fe2+, and is further stimulated by the presence of pyrophosphate.
Anita B. Roberts, Hector F. DeLuca
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Beyond-Rule-of-Five Compounds Are Not Different: In Vitro-In Vivo Extrapolation of Female CD-1 Mouse Clearance Based on Merck Healthcare KGaA Compound Set. [PDF]
Pharmaceuticals (Basel)Background: Extrapolation of intrinsic clearance from in vitro systems such as liver microsomes or hepatocytes is an established approach to predict clearance in preclinical species and in humans.
Maurer CK +4 more
europepmc +2 more sources
Antioxidants, 2023 Nitroxides are potent tools for studying biological systems by electron paramagnetic resonance (EPR). Whatever the application, a certain stability is necessary for successful detection.
Aleksandra Rančić +3 more
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Molecules, 2022 Capmatinib, a recently approved tyrosine kinase inhibitor, is used for the treatment of non-small cell lung cancer. We describe two new HPLC methods for capmatinib quantification in vivo and in vitro. HPLC with a fluorescence detection method was used to
Aref Zayed +5 more
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Toxins, 2023 A significant spread and prevalence of algal toxins and, in particular, marine biotoxins have been observed worldwide over the last decades. Marine biotoxins are natural contaminants produced during harmful algal blooms being accumulated in seafood, thus
Pablo Estevez, Ana Gago-Martinez
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Accelerating the Production of Druggable Targets: Eukaryotic Cell-Free Systems Come into Focus
Methods and Protocols, 2019 In the biopharmaceutical pipeline, protein expression systems are of high importance not only for the production of biotherapeutics but also for the discovery of novel drugs.
Lena Thoring +3 more
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Grasas y Aceites, 1996 18:2Δ 9c,12t and 18:2 Δ9t,12c are present in our diet, as result of heat treatment of vegetable oils. A nutritional study was carried out in order to obtain more precise information on the conversion of these two isomers into long chain polyunsaturated ...
Olivier Berdeaux +7 more
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Part Two: Evaluation of N-methylbupropion as a Potential Bupropion Prodrug
Pharmaceuticals, 2014 N-methylbupropion was selected as a potential prodrug from our in vitro screening of analogues of bupropion described in the preceding paper. This study describes in vivo pharmacokinetics of N-methylbupropion in the guinea-pig animal model, which is ...
Paul Matthew O'Byrne +3 more
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Improvement of the solubilization of proteins in two-dimensional electrophoresis with immobilized pH gradients [PDF]
Electrophoresis 18 (31/03/1997) 307-16, 2006 Membrane and nuclear proteins of poor solubility have been separated by high resolution two-dimensional (2-D) gel electrophoresis. Isoelectric focusing with immobilized pH gradients leads to severe quantitative losses of proteins in the resulting 2-D map, although the resolution is usually high.
arxiv +1 more source
Pharmaceutics, 2017 While assessing the ability of mammalian lung tissue to metabolize theophylline, a new metabolite was isolated and characterized. The metabolite was produced by the microsomal fraction of lungs from several species, including rat, rabbit, dog, pig, sheep
Daniel S. Sitar +4 more
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