Antioxidants, 2023 Nitroxides are potent tools for studying biological systems by electron paramagnetic resonance (EPR). Whatever the application, a certain stability is necessary for successful detection.
Aleksandra Rančić +3 more
doaj +1 more source
Ribonucleoparticle-independent transport of proteins into mammalian microsomes [PDF]
, 1990 There are at least two different mechanisms for the transport of secretory proteins into the mammalian endoplasmic reticulum. Both mechanisms depend on the presence of a signal peptide on the respective precursor protein and involve a signal peptide ...
Cobet, Werner W. E. +8 more
core +1 more source
Evaluation of Liver Microsomes for Genotoxicity Sensors—Voltammetry of the Microsomes [PDF]
The Electrochemical Society Interface, 2007 The 2007 Joseph W.
James F. Rusling, Sadagopan Krishnan
openaire +2 more sources
The synthesis of hemoglobin in a cell-free system [PDF]
, 1958 The microsomal particles (1) have been implicated as the major sites of protein synthesis within the cells of a variety of tissues. The studies of Borsook, Zamecnik, Hultin, and others, with intact animals and various types of whole cell systems (see ...
Allen, Esther +2 more
core +2 more sources
Enantioselective CE–MS analysis of ketamine metabolites in urine
ELECTROPHORESIS, Volume 44, Issue 1-2, Page 125-134, January 2023., 2023 Abstract The chiral drug ketamine has long‐lasting antidepressant effects with a fast onset and is also suitable to treat patients with therapy‐resistant depression. The metabolite hydroxynorketamine (HNK) plays an important role in the antidepressant mechanism of action.
Friederike A. Sandbaumhüter +5 more
wiley +1 more source
Studies on the hyperplasia ('regeneration') of the rat liver following partial hepatectomy. Changes in lipid peroxidation and general biochemical aspects [PDF]
, 1990 Using the experimental model of partial hepatectomy in the rat, we have examined the relationship between cell division and lipid peroxidation activity. In rats entrained to a regime of 12 h light/12 h dark and with a fixed 8 h feeding period in the dark
Benedetto, C +9 more
core +2 more sources
Frontiers in Pharmacology, 2018 Naftopidil (NAF) is widely used for the treatment of benign prostatic hyperplasia and prevention of prostate cancer in elderly men. These patients receive a combination of drugs, which involves high risk for drug–drug interaction.
Xia-Wen Liu +9 more
doaj +1 more source
Characterization of porcine hepatic and intestinal drug metabolizing CYP450 : comparison with human orthologues from a quantitative, activity and selectivity perspective [PDF]
, 2019 Over the past two decades, the pig has gained attention as a potential model for human drug metabolism. Cytochrome P450 enzymes (CYP450), a superfamily of biotransformation enzymes, are pivotal in drug metabolism.
Croubels, Siska +7 more
core +1 more source
Journal of Cell Biology, 1975 The data presented in this paper demonstrate that native small ribosomal subunits from reticulocytes (containing initiation factors) and large ribosomal subunits derived from free polysomes of reticulocytes by the puromycin-KCl procedures can function ...
G. Blobel, B. Dobberstein
semanticscholar +1 more source
Improvement of the solubilization of proteins in two-dimensional electrophoresis with immobilized pH gradients [PDF]
Electrophoresis 18 (31/03/1997) 307-16, 2006 Membrane and nuclear proteins of poor solubility have been separated by high resolution two-dimensional (2-D) gel electrophoresis. Isoelectric focusing with immobilized pH gradients leads to severe quantitative losses of proteins in the resulting 2-D map, although the resolution is usually high.
arxiv +1 more source