Results 191 to 200 of about 98,869 (304)

Preclinical pharmacokinetic characterization of (R)-ketamine injection, a novel antidepressant glutamatergic agent. [PDF]

Front Pharmacol
Wang R, Jin Y, Zou B, Ding L.
europepmc   +1 more source

FAD Transport and FAD-dependent Protein Thiol Oxidation in Rat Liver Microsomes [PDF]

, 2004
Marianne Varsányi, András Szarka, Eszter Papp, Dóra Makai, Gábor Nardai, Rosella Fulceri, Péter Csermely, József Mandl, Angelo Benedetti, Gábor Bánhegyi   +9 more
openalex   +1 more source

Evaluation of Pathogenic Variants Associated With Monogenic Disorders of Dyslipidemia in Patients With Well Characterised MASLD

Liver International, Volume 46, Issue 2, February 2026.
ABSTRACT Background and Aims Dyslipidemia is common in patients with MASLD, but the frequency and significance of inherited disorders of dyslipidemia are unclear. We investigated the prevalence and significance of pathogenic variants associated with selected monogenic disorders of dyslipidemia in 3358 patients with well‐characterised MASLD. Approach We
Tae‐Hwi Schwantes‐An, Marco A. Abreu, Brent A. Neuschwander‐Tetri, Jian Wang, Xiuqing Guo, Jingyi Tan, Robert A. Hegele, Nicholas O. Davidson, Luca Lotta, Niek Verweij, Katherine P. Yates, Jerome I. Rotter, Naga Chalasani   +12 more
wiley   +1 more source

Protein Levels of 16 Cytochrome P450s and 2 Carboxyl Esterases Using Absolute Quantitative Proteomics: CYP2C9 and CYP3A4 Are the Most Abundant Isoforms in Human Liver and Intestine, Respectively. [PDF]

Pharmaceuticals (Basel)
Grangeon A, Arwood ML, Thacker D, Gaudette F, Turgeon J, Michaud V.   +5 more
europepmc   +1 more source

Identification of In Vitro Metabolites of Amoxicillin in Human Liver Microsomes by LC–ESI/MS [PDF]

, 2014
Małgorzata Szultka‐Młyńska, Rafal Krzeminski, Marek Jackowski, Bogusław Buszewski   +3 more
openalex   +1 more source

Comparative in vitro biotransformation of fipronil in domestic poultry using liver microsome

, 2022
Kraisiri Khidkhan, Saranya Poapolathep, Sittinee Kulprasertsri, Rattapong Sukkheewan, Paphatsara Khunlert, Mario Gıorgı, Amnart Poapolathep   +6 more
openalex   +1 more source

Sex‐dependent role of 20‐HETE synthesis in outcome from ischemic stroke in rats

Physiological Reports, Volume 14, Issue 3, February 2026.
Abstract The lipid mediator 20‐HETE is produced by ω‐hydroxylation of arachidonic acid mediated by cytochrome P450 (CYP) enzymes including CYP4A, which has four distinct isoforms in rodents. Several laboratories demonstrated that 20‐HETE synthesis inhibition reduces infarct volume following middle cerebral artery occlusion (MCAO) in male animals. Here,
Rongrong Zhang, Yanrong Shi, Suyi Cao, Raymond C. Koehler, Zeng‐Jin Yang   +4 more
wiley   +1 more source

Humanization of Drug Metabolism in the <i>Plasmodium berghei</i> Mouse Model for Antimalarial Drug Discovery. [PDF]

ACS Infect Dis
MacLeod AK, Merino C, Viera-Morilla S, Frame L, Tavendale A, Duncan C, Ferguson L, Pinto EG, Simeons FRC, Gomez-Jimenez V, García AB, Riley J, Shishikura Y, Martínez-Martínez MS, Wolf CR, Read KD.   +15 more
europepmc   +1 more source

Purified NADPH cytochrome P-450 reductase. Interaction with hepatic microsomes and phospholipid vesicles.

, 1979
James R. Gum, Henry W. Strobel
openalex   +1 more source

Peer review of the pesticide risk assessment of the active substance paraffin oil (CAS 97862‐82‐3, chain lengths C16–C28)

EFSA Journal, Volume 24, Issue 2, February 2026.
Abstract The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State Greece and co‐rapporteur Member State France for the pesticide active substance paraffin oil (CAS 97862‐82‐3) are reported. The context of the peer review
European Food Safety Authority (EFSA), Fernando Álvarez, Maria Arena, Domenica Auteri, Sofia Batista Leite, Amarela Becirovic, Marco Binaglia, Anna Federica Castoldi, Arianna Chiusolo, Angelo Colagiorgi, Mathilde Colas, Federica Crivellente, Chloe De Lentdecker, Isabella De Magistris, Mark Egsmose, Gabriella Fait, Franco Ferilli, German Giner Santonja, Varvara Gouliarmou, Katrin Halling, Alessio Ippolito, Frederique Istace, Dimitra Kardassi, Aude Kienzler, Anna Lanzoni, Roberto Lava, Renata Leuschner, Alberto Linguadoca, Mariano Lopez Romano, Jochem Louisse, Christopher Lythgo, Oriol Magrans, Iris Mangas, Andrea Mioč, Ileana Miron, Tunde Molnar, Laura Padovani, Vincenzo Padricello, Martina Panzarea, Juan Manuel Parra Morte, Simone Rizzuto, Miguel Santos, Rositsa Serafimova, Rachel Sharp, Csaba Szentes, Anne Theobald, Manuela Tiramani, Giorgia Vianello, Laura Villamar‐Bouza   +48 more
wiley   +1 more source