Results 31 to 40 of about 97,218 (302)

A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response [PDF]

, 2008
The pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) are closely related orphan nuclear hormone receptors that play a critical role as xenobiotic sensors in mammals.
Anja Rode, Baes, Bauer, Branko Zevnik, C. Roland Wolf, Dotzlaw, Forrester, Hustert, Jillian Ross, Kocarek, Lowry, Lukas, Meehan, Nico Scheer, Nicole Faust, Poland, Sandra Niehaves, Smith, Wolf, Wrighton   +19 more
core   +4 more sources

The composition of rat liver microsomes. The structural proteins of rat liver microsomes [PDF]

Biochemical Journal, 1969
1. The structural-protein component of microsomal membranes was isolated by three separate methods. Analysis by polyacrylamide-gel electrophoresis indicated that the microsomal structural component is made up of a heterogeneous group of proteins. These proteins were further characterized by their phospholipid-binding capacity.
J. K. Pollak, K. A. Ward
openaire   +3 more sources

Effects of free fatty acids on the enzymic synthesis of diacyl and ether types of choline and ethanolamine phosphoglycerides

Journal of Lipid Research, 1976
Activities of ethanolaminephosphotransferases (EC 2.7.8.1) and choline phosphotransferases (EC 2.7.8.2) in microsomal fractions from brains and livers of mature rats are increased several fold by the addition of 1,2-diacyl-sn-glycerols or 1-alkyl-2-acyl ...
A Radominska-Pyrek, J Strosznajder, Z Dabrowiecki, T Chojnacki, L A Horrocks   +4 more
doaj   +1 more source

Changes of microsomal membrane compositions modulate microsomal enzyme activity [PDF]

Pediatric Research, 1979
We have shown previously, that the activity of cerebrosulfotransferase (CST) a microsomal enzyme involved in myelin synthesis is modulated in vitro by the cholesterol-phospholipid ratio (C/P) in microsomal membranes. To further investigate this mechanism, we studied two different models: 1.) Removal of cholesterol by phospholipid micelles and 2 ...
H. Jutzi, Norbert Herschkowitz, Ulrich N. Wiesmann, H P Siegrist   +3 more
openaire   +2 more sources

Aberrant pathways in the late stages of cholesterol biosynthesis in the rat: origin and metabolic fate of unsaturated sterols relevant to the Smith-Lemli-Opitz syndrome

Journal of Lipid Research, 2000
Minor aberrant pathways of cholesterol biosynthesis normally produce only trace levels of abnormal sterol metabolites but may assume major importance when an essential biosynthetic step is blocked.
Benfang Ruan, James Tsai, William K. Wilson, George J. Schroepfer, Jr.   +3 more
doaj   +1 more source

Newly Synthesized Creatine Derivatives as Potential Neuroprotective and Antioxidant Agents on In Vitro Models of Parkinson’s Disease

Life, 2023
Oxidative stress is one of the key factors responsible for many diseases–neurodegenerative (Parkinson and Alzheimer) diseases, diabetes, atherosclerosis, etc.
Ivanka Kostadinova, Magdalena Kondeva-Burdina, Lyubomir Marinov, Lubomir L. Vezenkov, Rumyana Simeonova   +4 more
doaj   +1 more source

Analyses of CYP2C in Porcine Microsomes [PDF]

Basic & Clinical Pharmacology & Toxicology, 2008
Abstract: The cytochrome P450 2C (CYP2C) subfamily in human beings includes four different isoenzymes that metabolize different substrates although with some cross reactivity. Some of these substrates (e.g. diclofenac and tolbutamide), have been investigated in porcine microsomes, but without identifying the specific CYP catalysing the reactions.
Skaanild, Mette Tingleff, Friis, Christian   +1 more
openaire   +5 more sources

Δ6- and Δ5-desaturase activities in the human fetal liver: kinetic aspects

Journal of Lipid Research, 1998
Δ6- and Δ5-desaturase activities were studied in human fetal liver microsomes obtained after legally approved therapeutic abortion. Enzyme activities were measured by a radiochemical method using reverse-phase high performance liquid chromatography (HPLC)
Annie Rodriguez, Pierre Sarda, Catherine Nessmann, Pierre Boulot, Claude Louis Leger, Bernard Descomps   +5 more
doaj   +1 more source

Physiology-based IVIVE predictions of tramadol from in vitro metabolism data [PDF]

, 2014
To predict the tramadol in vivo pharmacokinetics in adults by using in vitro metabolism data and an in vitro-in vivo extrapolation (IVIVE)-linked physiologically-based pharmacokinetic (PBPK) modeling and simulation approach (SimcypA (R)).
Allegaert, Karel, Annaert, Pieter, Boussery, Koen, Colin, Pieter, Cuyckens, Filip, Mannens, Geert, Snoeys, Jan, T'jollyn, Huybrecht, Van Bocxlaer, Jan, Van Peer, Achiel, Vermeulen, An   +10 more
core   +1 more source

NUCLEOSIDE-DIPHOSPHATASE OF CESTODE BOTHRIOCEPHALUS SCORPII (CESTODA: BOTHRIOCEPHALIDAE)

Российский паразитологический журнал, 2016
Objective of research: To study the activities and properties of nucleoside- diphosphatase (NDPase) in cestode Bothriocephalus scorpii.Materials and methods: Cestodes were homogenized with 10 vol. of extraction medium. NDPase was detected in mitochondria
E. A. Burenina
doaj   +1 more source