Results 31 to 40 of about 47,963 (298)

NUCLEOSIDE-DIPHOSPHATASE OF CESTODE BOTHRIOCEPHALUS SCORPII (CESTODA: BOTHRIOCEPHALIDAE)

Российский паразитологический журнал, 2016
Objective of research: To study the activities and properties of nucleoside- diphosphatase (NDPase) in cestode Bothriocephalus scorpii.Materials and methods: Cestodes were homogenized with 10 vol. of extraction medium. NDPase was detected in mitochondria
E. A. Burenina
doaj   +1 more source

Novel Less Toxic, Lymphoid Tissue‐Targeted Lipid Nanoparticles Containing a Vitamin B5‐Derived Ionizable Lipid for mRNA Vaccine Delivery

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
The top‐performing lipid nanoparticle, incorporating a novel ionizable lipid derived from vitamin B5, demonstrates high mRNA transfection efficiency, low toxicity, favorable stability, targeted delivery to lymphoid tissues, and high immunogenicity, showing promise as a carrier for mRNA vaccines for infectious diseases and cancer.
Soyeon Yoo, Muhammad Faisal, Seo‐Hyeon Bae, Kounghwa Youn, Hyo‐Jung Park, Sung Pil Kwon, Il Kwon Hwang, Jisun Lee, Hyeong Jun Kim, Jae‐Hwan Nam, Gyochang Keum, Eun‐Kyoung Bang   +11 more
wiley   +1 more source

Revisiting the Latency of Uridine Diphosphate-Glucuronosyltransferases (UGTs)—How Does the Endoplasmic Reticulum Membrane Influence Their Function?

Pharmaceutics, 2017
Uridine diphosphate-glucuronosyltransferases (UGTs) are phase 2 conjugation enzymes mainly located in the endoplasmic reticulum (ER) of the liver and many other tissues, and can be recovered in artificial ER membrane preparations (microsomes).
Yuejian Liu, Michael W. H. Coughtrie
doaj   +1 more source

DNA‐PKcs‐Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia‐Induced Cardiac Dysfunction in Type 1 Diabetes

Advanced Science, EarlyView.
In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang, Xing Chang, Chun Li, Jing Gao, Zhijiang Guo, Haowen Zhuang, Lingjun Wang, Yusheng Huang, Wei Wang, Chao Li, Qingyong He   +10 more
wiley   +1 more source

Functional Reconstitution of Membrane Proteins Derived From Eukaryotic Cell-Free Systems

Frontiers in Pharmacology, 2019
Cell-free protein synthesis (CFPS) based on eukaryotic Sf21 lysate is gaining interest among researchers due to its ability to handle the synthesis of complex human membrane proteins (MPs).
Srujan Kumar Dondapati, Henning Lübberding, Anne Zemella, Lena Thoring, Doreen A. Wüstenhagen, Stefan Kubick, Stefan Kubick   +6 more
doaj   +1 more source

Evaluation of herb-drug interaction of ambrisentan with shikonin based on UPLC-MS/MS

Pharmaceutical Biology, 2021
Context Ambrisentan is an oral endothelin-receptor antagonist (ERA). However, there is no report on the interaction between ambrisentan and shikonin.
Tian Lan, Ping Fang, Xuemei Ye, Xia Lan, Ren-ai Xu   +4 more
doaj   +1 more source

Loss of STARD7 Triggers Metabolic Reprogramming and Cell Cycle Arrest in Breast Cancer

Advanced Science, EarlyView.
Breast cancer cells undergo metabolic and transcriptomic reprogramming to support aberrant cell proliferation. Their mitochondria rely on the transfer of phosphatidylcholine from the endoplasmic reticulum to their membranes by STARD7, a candidate upregulated in breast cancer, to be functional.
Ewelina Dondajewska, Paula Allepuz‐Fuster, Chloé Maurizy, Alexandre Hego, Sandra Ormenese, Quentin Lion, Arnaud Blomme, Pierre Close, Arnaud Lavergne, Latifa Karim, Marc Thiry, Ivan Nemazanyy, Roopesh Krishnankutty, Jair Marques Jr, Alex von Kriegsheim, Nathaniel F. Henneman, Ganna Panasyuk, Kateryna Shostak, Alain Chariot   +18 more
wiley   +1 more source

Newly Synthesized Creatine Derivatives as Potential Neuroprotective and Antioxidant Agents on In Vitro Models of Parkinson’s Disease

Life, 2023
Oxidative stress is one of the key factors responsible for many diseases–neurodegenerative (Parkinson and Alzheimer) diseases, diabetes, atherosclerosis, etc.
Ivanka Kostadinova, Magdalena Kondeva-Burdina, Lyubomir Marinov, Lubomir L. Vezenkov, Rumyana Simeonova   +4 more
doaj   +1 more source

OXidative Stress PREDictor: A Supervised Learning Approach for Annotating Cellular Oxidative Stress States in Inflammatory Cells

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
OxSpred, an eXtreme‐Gradient‐Boosting‐‐based supervised learning model, accurately annotates oxidative stress in innate immune cells at the single‐cell level, providing interpretable embeddings with significant biological relevance. This innovative tool revolutionizes the understanding of innate immune cell functions during inflammation and enhances ...
Po‐Yuan Chen, Tai‐Ming Ko
wiley   +1 more source

Progress in Biomimetic Microdevices for Anticancer Drug Screening and their Potential for Enhancing In Vivo Efficacy

Advanced NanoBiomed Research, EarlyView.
Biomimetic microdevices are redefining anticancer drug screening by mimicking complex tumor microenvironments. This review highlights advances in microfluidic systems, cell microarrays, and in vivo‐like models, offering new insights into drug efficacy prediction and personalized medicine. The development of effective anticancer drugs remains a critical
Ching‐Te Kuo, Yen‐Tzu Liao, Hsinyu Lee   +2 more
wiley   +1 more source