Results 41 to 50 of about 98,869 (304)

Structural analysis of phosphatidylcholine of plant tissue

open access: yesJournal of Lipid Research, 1971
Pure preparations of phosphatidylcholine were isolated from spinach leaf chloroplasts, spinach leaf microsomes, and cauliflower inflorescence. The isolated phosphatidylcholine was treated with snake venom phospholipase A, and the fatty acid distribution ...
K.A. DEVOR, J.B. MUDD
doaj   +1 more source

Microsomal superoxide anion production and NADPH-oxidation in a series of 22 aziridinylbenzoquinones [PDF]

open access: yes, 1989
Several 2,5-bis(1-aziridinyl)-1,4-benzoquinones (BABQs) can be activated to alkylating species by reduction of the quinone moiety. On the other hand, cytotoxicity of these compounds can be induced by redox cycling.
Koster, Andries Sj.   +3 more
core   +3 more sources

DualPG‐DTA: A Large Language Model‐Powered Graph Neural Network Framework for Enhanced Drug‐Target Affinity Prediction and Discovery of Novel CDK9 Inhibitors Exhibiting in Vivo Anti‐Leukemia Activity

open access: yesAdvanced Science, EarlyView.
This study introduces DualPG‐DTA, a framework integrating two pre‐trained models to generate molecular and protein representations. It constructs dual graphs processed by specialized neural networks with dynamic attention for feature fusion, achieving superior benchmark performance.
Yihao Chen   +7 more
wiley   +1 more source

Phospholipids and acyl groups in subcellular fractions from human cerebral cortex

open access: yesJournal of Lipid Research, 1973
Subcellular fractionation of human brain cortex obtained at autopsy yielded microsomal and synaptosome-rich fractions from the gray matter and microsomal and purified myelin fractions from the white matter.
Grace Y. Sun
doaj   +1 more source

UPLC-MS/MS analysis of ochratoxin A metabolites produced by Caco-2 and HepG2 cells in a co-culture system [PDF]

open access: yes, 2017
Ochatoxin A (OTA) is one of the most important mycotoxins based on its toxicity. The oral route is the main gateway of entry of OTA into the human body, and specialized epithelial cells constitute the first barrier.
González Arias, Cyndia A.   +4 more
core   +2 more sources

Multi‐View Biomedical Foundation Models for Molecule‐Target and Property Prediction

open access: yesAdvanced Science, EarlyView.
Molecular foundation models can provide accurate predictions for a large set of downstream tasks. We develop MMELON, an approach that integrates pre‐trained graph, image, and text foundation models and validate our multi‐view model on over 120 tasks, including GPCR binding.
Parthasarathy Suryanarayanan   +17 more
wiley   +1 more source

Metabolism of palmitic acid in the subcellular fractions of mouse brain

open access: yesJournal of Lipid Research, 1973
After an intracerebral injection of [14C]palmitic acid to C57BL/10J mice, the radioactivity in the brains decreased rapidly with time. The incorporated radioactivity was primarily in the 16:0 acyl groups of the diacyl phosphoglycerides at 1 and 3 days ...
Grace Y. Sun, Lloyd A. Horrocks
doaj   +1 more source

An ancestral secretory apparatus in the protozoan parasite Giardia intestinalis [PDF]

open access: yes, 2003
The protozoan parasite Giardia intestinalis belongs to one of the earliest diverged eukaryotic lineages. This is also reflected in a simple intracellular organization, as Giardia lacks common subcellular compartments such as mitochondria, peroxisomes ...
Hehl, Adrian B.   +7 more
core   +1 more source

Microsomal triglyceride transfer protein [PDF]

open access: yesBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1997
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Wetterau, JR, Lin, MCM, Jamil, H
openaire   +4 more sources

Fluorinated Hypoxia‐Responsive Aza‐BODIPY for NIR‐II FL/19F MR/PA Imaging and Phototherapy of Lung Cancer

open access: yesAdvanced Science, EarlyView.
Fluorinated N‐oxide aza‐BODIPY nanoemulsions integrate fluorination‐driven molecular design with co‐assembly in fluorinated oil for multimodal imaging‐guided phototherapy. The co‐assembly redshifts fluorescence into the NIR‐II window for deep‐tissue imaging and provides a unified 19F signal for background‐free, quantitative MRI.
Anfeng Li   +5 more
wiley   +1 more source

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