Microtubule-Associated Protein EB3 Regulates IP3 Receptor Clustering and Ca(2+) Signaling in Endothelial Cells. [PDF]
, 2015 The mechanisms by which the microtubule cytoskeleton regulates the permeability of endothelial barrier are not well understood. Here, we demonstrate that microtubule-associated end-binding protein 3 (EB3), a core component of the microtubule plus-end ...
F. Huang (2379355) +6 more
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Kank Is an EB1 Interacting Protein that Localises to Muscle-Tendon Attachment Sites in Drosophila [PDF]
, 2014 Little is known about how microtubules are regulated in different cell types during development. EB1 plays a central role in the regulation of microtubule plus ends.
Hiroyuki Ohkura (90476) +11 more
core +1 more source
Association of CFH and MAP1LC3B gene polymorphisms with age-related macular degeneration in a high-altitude population [PDF]
International Journal of Ophthalmology, 2022 AIM: To evaluate the association of complement factor H (CFH) and microtubule-associated protein 1 light chain 3 beta (MAP1LC3B) gene polymorphisms with the risk of age-related macular degeneration (AMD) in a high-altitude population.
Rui-Juan Guan +5 more
doaj +1 more source
Exploring the functional domain and the target of the tetanus toxin light chain in neurohypophysial terminals [PDF]
, 1994 The tetanus toxin light chain blocks calcium induced vasopressin release from neurohypophysial nerve terminals. Here we show that histidine residue 233 within the putative zinc binding motif of the tetanus toxin light chain is essential for the ...
Weller, U. +7 more
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Mitotic centromere-associated kinesin (MCAK) : a potential cancer drug target [PDF]
, 2011 The inability to faithfully segregate chromosomes in mitosis results in chromosome instability, a hallmark of solid tumors. Disruption of microtubule dynamics contributes highly to mitotic chromosome instability.
Yuan, Juping +4 more
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Precision Radiation Oncology, 2020 Objectives Although nasopharyngeal carcinoma (NPC) is sensitive to radiotherapy, local recurrence and distant metastasis still occur in a proportion of patients due to radioresistance.
Zenan Chen, Yanrong Hao
doaj +1 more source
Neuronal deletion of GSK3beta increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2 [PDF]
, 2014 BackgroundIn the adult central nervous system, axonal regeneration is abortive. Regulators of microtubule dynamics have emerged as attractive targets to promote axonal growth following injury as microtubule organization is pivotal for growth cone ...
Sílvia Vieira +25 more
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Functional coupling of microtubules to membranes - implications for membrane structure and dynamics [PDF]
, 2012 The microtubule network dictates much of the spatial patterning of the cytoplasm, and the coupling of microtubules to membranes controls the structure and positioning of organelles and directs membrane trafficking between them.
Stephens, David J
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Wedelolactone facilitates the early development of parthenogenetically activated porcine embryos by reducing oxidative stress and inhibiting autophagy [PDF]
PeerJ, 2022 Wedelolactone (WDL) is a coumaryl ether compound extracted from the traditional Chinese medicinal plant, Eclipta prostrata L. It is a natural polyphenol that exhibits a variety of pharmacological activities, such as anti-inflammatory, anti-free radical ...
Xin-Qin Wang +7 more
doaj +2 more sources
A novel regulator of selective autophagy: TNIP1/ABIN-1 modulates mitophagy
Autophagy Reports, 2023 TNIP1/ABIN-1 is a novel inhibitor of inflammation and cell death. In our study, we elucidated the MAP1LC3/LC3 (microtubule associated protein 1 light chain 3)-interacting region (LIR) 1 and 2 motifs of TNIP1-dependent direct binding to LC3B-II and ...
Rosetta Merline, Liliana Schaefer
doaj +1 more source