Regulation of cell migration by dynamic microtubules [PDF]
, 2011 Microtubules define the architecture and internal organization of cells by positioning organelles and activities, as well as by supporting cell shape and mechanics. One of the major functions of microtubules is the control of polarized cell motility.
Irina Kaverina +3 more
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The adenomatous polyposis coli protein unambiguously localizes to microtubule plus-ends and is involved in establishing parallel arrays of microtubule bundles in highly polarised epithelial cells [PDF]
, 2002 Loss of full-length adenomatous polyposis coli (APC) protein correlates with the development of colon cancers in familial and sporadic cases. In addition to its role in regulating ß-catenin levels in the Wnt signaling pathway, the APC protein is ...
John B. Mackie +16 more
core +1 more source
Structural intermediates in the assembly of taxoid-induced microtubules and GDP-tubulin double rings: time-resolved X-ray scattering [PDF]
, 1996 We have studied the self-association reactions of purified GDP-liganded tubulin into double rings and taxoid-induced microtubules, employing synchrotron time-resolved x-ray solution scattering.
Diaz, J.F. +6 more
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Herpesvirus lytic infection-induced mitophagy via viral interferon regulatory factor 1
Autophagy Reports, 2023 Viral control of mitochondria via mitophagy has a dampening effect on mitochondrion-mediated innate immune responses. We previously found that human herpesvirus 8 (HHV-8) could activate mitophagy via its lytic gene product vIRF-1 (viral interferon ...
Mai Tram Vo, Young Bong Choi
doaj +1 more source
Bod1, a novel kinetochore protein required for chromosome biorientation [PDF]
, 2007 We have combined the proteomic analysis of Xenopus laevis in vitro–assembled chromosomes with RNA interference and live cell imaging in HeLa cells to identify novel factors required for proper chromosome segregation. The first of these is Bod1, a protein
McClelland, Sarah E. +25 more
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Universal and unique features of kinesin motors: Insights from a comparison of fungal and animal conventional kinesins [PDF]
, 1999 Kinesins are microtubule motors that use the energy derived from the hydrolysis of ATP to move unidirectionally along microtubules, The founding member of this still growing superfamily is conventional kinesin, a dimeric motor that moves processively ...
Woehlke, G. +5 more
core +1 more source
针刺研究, 2019 ObjectiveTo observe the effect of penetrative needling from"Baihui"(GV20)to"Qubin"(GB7)on neurological function and expression of autophagy related protein microtubule-associated protein,light chain 3(LC3)in rats with hemorrhagic stroke,so as to explore ...
LIU Hao +8 more
doaj +2 more sources
DRAMs and autophagy: a family affair
Autophagy Reports, 2022 Macroautophagy/autophagy is a conserved catabolic process that delivers intracellular materials to lysosomes for degradation. This process promotes cell survival by maintaining cellular homeostasis and supplying substrates to produce energy during ...
Valentin J. A. Barthet, Kevin M. Ryan
doaj +1 more source
Structural insights into the recognition of phosphorylated FUNDC1 by LC3B in mitophagy
Protein & Cell, 2016 Mitophagy is an essential intracellular process that eliminates dysfunctional mitochondria and maintains cellular homeostasis. Mitophagy is regulated by the post-translational modification of mitophagy receptors. Fun14 domain-containing protein 1 (FUNDC1)
Mengqi Lv +7 more
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Effect of miR-183 targeting Bnip3l on mitochondrial autophagy in hypoxia/reoxygenated hippocampal neurons in mice [PDF]
Jichu yixue yu linchuang, 2021 Objective To explore the mechanism of miR-183 regulating mitochondrial autophagy in hypoxia/reoxygenated(H/R) hippocampal neurons. Methods The mouse hippocampal neuron HT-22 cells were collected and divided into control group, hypoxia/reoxygenation(H/R)
MA Jia-ling, GAO Yan-ping
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