Results 31 to 40 of about 417,156 (275)

Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau

Nature Communications, 2017
The protein Tau aggregates into tangles in the brain of patients with Alzheimer’s disease. In solution, however, Tau is intrinsically disordered, highly soluble, and binds to microtubules.
S. Ambadipudi, J. Biernat, D. Riedel, E. Mandelkow, M. Zweckstetter   +4 more
semanticscholar   +1 more source

Microtubules, microtubule-interfering agents and apoptosis.

Apoptosis : an international journal on programmed cell death, 2003
Microtubules are dynamic polymers that play crucial roles in a large number of cellular functions. Their pivotal role in mitosis makes them a target for the development of anticancer drugs. Microtubule-damaging agents suppress microtubule dynamics, leading to disruption of the mitotic spindle in dividing cells, cell cycle arrest at M phase, and late ...
Mollinedo, Faustino, Gajate, Consuelo
openaire   +4 more sources

A mutation uncouples the tubulin conformational and GTPase cycles, revealing allosteric control of microtubule dynamics

eLife, 2015
Microtubule dynamic instability depends on the GTPase activity of the polymerizing αβ-tubulin subunits, which cycle through at least three distinct conformations as they move into and out of microtubules.
Elisabeth A Geyer, Alexander Burns, Beth A Lalonde, Xuecheng Ye, Felipe-Andres Piedra, Tim C Huffaker, Luke M Rice   +6 more
doaj   +1 more source

A protein factor essential for microtubule assembly.

Proceedings of the National Academy of Sciences of the United States of America, 1975
A heat stable protein essentail for microtubule assembly has been isolated. This protein, which we designate tau (tau), is present in association with tubulin purified from porcine brain by repeated cycles of polymerization. Tau is separated from tubulin
M. Weingarten, A. Lockwood, S. Hwo, M. Kirschner   +3 more
semanticscholar   +1 more source

A "MICROTUBULE" IN A BACTERIUM [PDF]

The Journal of Cell Biology, 1967
A study of the anchorage of the flagella in swarmers of Proteus mirabilis led to the incidental observation of microtubules. These microtubules were found in thin sections and in whole mount preparations of cells from which most of the content had been released by osmotic shock before staining negatively with potassium phosphotungstate (PTA).
Judith F. M. Hoeniger, Woutera van Iterson, Eva Nijman van Zanten   +2 more
openaire   +3 more sources

TUBB4A mutations result in both glial and neuronal degeneration in an H-ABC leukodystrophy mouse model

eLife, 2020
Mutations in TUBB4A result in a spectrum of leukodystrophy including Hypomyelination with Atrophy of Basal Ganglia and Cerebellum (H-ABC), a rare hypomyelinating leukodystrophy, often associated with a recurring variant p.Asp249Asn (D249N).
Sunetra Sase, Akshata A Almad, C Alexander Boecker, Pedro Guedes-Dias, Jian J Li, Asako Takanohashi, Akshilkumar Patel, Tara McCaffrey, Heta Patel, Divya Sirdeshpande, Julian Curiel, Judy Shih-Hwa Liu, Quasar Padiath, Erika LF Holzbaur, Steven S Scherer, Adeline Vanderver   +15 more
doaj   +1 more source

Regulation of Tubulin Gene Expression: From Isotype Identity to Functional Specialization

Frontiers in Cell and Developmental Biology, 2022
Genomes of higher eukaryotes encode a large tubulin gene superfamily consisting of at least six α and six β-tubulin isotypes. While some α and β-tubulin isotypes are ubiquitously expressed, others are cell-type specific.
Ivana Gasic
doaj   +1 more source

Microtubule-severing enzymes: From cellular functions to molecular mechanism. [PDF]

, 2018
Microtubule-severing enzymes generate internal breaks in microtubules. They are conserved in eukaryotes from ciliates to mammals, and their function is important in diverse cellular processes ranging from cilia biogenesis to cell division, phototropism ...
Ahmad, Akhmanova, Akhmanova, Allison, Antonina Roll-Mecak, Aubin-Tam, Banks, Barton, Benz, Bichet, Burk, Burk, Carlier, Carlier, Carlier, Charafeddine, Cheung, Chi, Connell, Denton, DeSantis, DesMarais, Dominguez, Dong, Doyle, Dymek, Dymek, Díaz-Valencia, Eckert, Evans, Francis J. McNally, Ganem, Gates, Grode, Guizetti, Han, Hara, Hartman, Hartman, Hawkins, Hazan, Hu, Hu, Iwaya, Jiang, Jiang, Jiang, Johjima, Joly, Kasher, Keating, Lacroix, Lata, Lee, Leo, Lindeboom, Liu, Loughlin, Lundin, Lučič, Maillard, Mains, Mao, Matsuo, McNally, McNally, McNally, McNally, McNally, McNally, Minoura, Mishra-Gorur, Mitchison, Monroe, Moretti, Mukherjee, Murata, Nakamura, Nicklas, Nithianantham, Olivares, Park, Peng, Portis, Puchades, Qiang, Rao, Reid, Rezabkova, Ribbeck, Rogers, Roll-Mecak, Roll-Mecak, Roll-Mecak, Roll-Mecak, Sharma, Sharp, Shaw, Sherwood, Sonbuchner, Srayko, Stamatakis, Stewart, Stone, Tao, Taylor, Ti, Tirnauer, Tran, Trotta, Vale, Valenstein, Vemu, Vemu, Vietri, Walker, Wang, Waterman-Storer, Wen, White, Whitehead, Wightman, Yang, Yang, Yang, Yu, Zehr, Zhang, Zhang, Zhang, Zhao   +130 more
core   +2 more sources

Effects of α-tubulin acetylation on microtubule structure and stability

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Microtubules are polymers of αβ-tubulin that play important roles in the cell. Regulation of their dynamics is critical for function and includes the posttranslational modification of tubulin.
L. Eshun-Wilson, Rui Zhang, D. Portran, M. Nachury, D. Toso, Thomas Löhr, M. Vendruscolo, Massimiliano Bonomi, J. Fraser, E. Nogales   +9 more
semanticscholar   +1 more source

SSNA1 stabilizes dynamic microtubules and detects microtubule damage [PDF]

eLife, 2021
Sjögren’s syndrome nuclear autoantigen-1 (SSNA1/NA14) is a microtubule-associated protein with important functions in cilia, dividing cells, and developing neurons. However, the direct effects of SSNA1 on microtubules are not known. We employed in vitro reconstitution with purified proteins and TIRF microscopy to investigate the activity of human SSNA1
Elizabeth J Lawrence, Goker Arpag, Cayetana Arnaiz, Marija Zanic   +3 more
openaire   +4 more sources