Results 51 to 60 of about 417,156 (275)

Subcellular and supracellular mechanical stress prescribes cytoskeleton behavior in Arabidopsis cotyledon pavement cells

eLife, 2014
Although it is a central question in biology, how cell shape controls intracellular dynamics largely remains an open question. Here, we show that the shape of Arabidopsis pavement cells creates a stress pattern that controls microtubule orientation ...
Arun Sampathkumar, Pawel Krupinski, Raymond Wightman, Pascale Milani, Alexandre Berquand, Arezki Boudaoud, Olivier Hamant, Henrik Jönsson, Elliot M Meyerowitz   +8 more
doaj   +1 more source

Structural plasticity of the living kinetochore [PDF]

, 2017
The kinetochore is a large, evolutionarily conserved protein structure that connects chromosomes with microtubules. During chromosome segregation, outer kinetochore components track depolymerizing ends of microtubules to facilitate the separation of ...
Akiyoshi, Al-Bassam, Aravamudhan, Aravamudhan, Asbury, Biggins, Biggins, Boris Rubinstein, Brian D. Slaughter, Chan, Cheeseman, Culotti, Daniel, De Wulf, Desai, Duffy, Field, Foley, Gandhi, Gao, Gardner, Gestaut, Grishchuk, Guimaraes, Hartwell, He, Hedges, Hill, Hornung, Hornung, Jaspersen, Jay R. Unruh, Jeffrey J. Lange, Jennifer L. Gerton, Jin, Jin, Joglekar, Joglekar, Joglekar, Joglekar, Karthik Dhatchinamoorthy, Kim, Kosco, Lampert, Liu, Longtine, Mallavarapu, Malvezzi, Manjunatha Shivaraju, Mayer, McAinsh, McIntosh, McKinney, Meng, Mieck, Miller, Miranda, Ng, Obuse, Pavelka, Pearson, Pfau, Podolski, Powers, Ramey, Sarangapani, Schleiffer, Schmidt, Severin, Shivaraju, Smith, Stephens, Su, Suzuki, Tanaka, Tien, Tytell, Umbreit, Usui, van Breugel, van Hooff, Visintin, Walczak, Wang, Welburn, Westermann, Westermann, Winey, Wisniewski, Wolyniak, Yuen   +90 more
core   +1 more source

Structural basis for the assembly of the mitotic motor Kinesin-5 into bipolar tetramers

eLife, 2014
Chromosome segregation during mitosis depends upon Kinesin-5 motors, which display a conserved, bipolar homotetrameric organization consisting of two motor dimers at opposite ends of a central rod.
Jessica E Scholey, Stanley Nithianantham, Jonathan M Scholey, Jawdat Al-Bassam   +3 more
doaj   +1 more source

The Novel KIF1A Missense Variant (R169T) Strongly Reduces Microtubule Stimulated ATPase Activity and Is Associated With NESCAV Syndrome

Frontiers in Neuroscience, 2021
KIF1A is a microtubule-dependent motor protein responsible for fast anterograde transport of synaptic vesicle precursors in neurons. Pathogenic variants in KIF1A have been associated with a wide spectrum of neurological disorders.
Cinthia Aguilera, Stefan Hümmer, Stefan Hümmer, Marc Masanas, Elisabeth Gabau, Miriam Guitart, A. Arockia Jeyaprakash, Miguel F. Segura, Anna Santamaria, Anna Ruiz   +9 more
doaj   +1 more source

Microtubules born on microtubules

The Journal of Cell Biology, 2005
![Graphic][1] A new MT is nucleated (white arrowhead) by a γ-TuC (green) that sits on an existing MT bundle.Microtubule (MT) arrays form, say Janson et al. ( [page 297][2]), when MT nucleators stick to existing MTs.
openaire   +3 more sources

Are microtubules tension sensors? [PDF]

Nature Communications, 2019
AbstractMechanical signals play many roles in cell and developmental biology. Several mechanotransduction pathways have been uncovered, but the mechanisms identified so far only address the perception of stress intensity. Mechanical stresses are tensorial in nature, and thus provide dual mechanical information: stress magnitude and direction.
Hamant, Olivier, Inoue, Daisuke, Bouchez, David, Dumais, Jacques, Mjolsness, Eric   +4 more
openaire   +8 more sources

A transgenic toolkit for visualizing and perturbing microtubules reveals unexpected functions in the epidermis

eLife, 2017
The physiological functions of microtubules (MTs) are poorly understood in many differentiated cell types. We developed a genetic toolkit to study MT dynamics and function in diverse cells.
Andrew Muroyama, Terry Lechler
doaj   +1 more source

The speed of GTP hydrolysis determines GTP cap size and controls microtubule stability

eLife, 2020
Microtubules are cytoskeletal polymers whose function depends on their property to switch between states of growth and shrinkage. Growing microtubules are thought to be stabilized by a GTP cap at their ends.
Johanna Roostalu, Claire Thomas, Nicholas Ian Cade, Simone Kunzelmann, Ian A Taylor, Thomas Surrey   +5 more
doaj   +1 more source

Modeling the Effects of Drug Binding on the Dynamic Instability of Microtubules

, 2011
We propose a stochastic model that accounts for the growth, catastrophe and rescue processes of steady state microtubules assembled from MAP-free tubulin.
Correia J J, Jack A Tuszyński, Lin C M, Lopus M, Manu Lopus, Mary Ann Jordan, Peter Hinow, Vahid Rezania, Yenjerla M   +8 more
core   +1 more source

NAP (davunetide) rescues neuronal dysfunction in a Drosophila model of tauopathy [PDF]

, 2013
Alzheimer’s disease (AD) is a devastating neurodegenerative disease causing irreversible cognitive decline in the elderly. There is no disease-modifying therapy for this condition and the mechanisms underpinning neuronal dysfunction and neurodegeneration
Cowan, C.M., Mudher, A., Quraishe, S.
core   +1 more source