Results 61 to 70 of about 406,325 (331)

The Mating-specific Gα Interacts with a Kinesin-14 and Regulates Pheromone-induced Nuclear Migration in Budding Yeast [PDF]

, 2009
As a budding yeast cell elongates toward its mating partner, cytoplasmic microtubules connect the nucleus to the cell cortex at the growth tip.
Cooper, John A, Draper, Edward, Durbrovskyi, Oleksii, Metodiev, Metodi V, Nelson, Scott A, Stone, David E, Zaichick, Sofia V   +6 more
core   +4 more sources

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Novel loss of function mutation in TUBA1A gene compromises tubulin stability and proteostasis causing spastic paraplegia and ataxia

Frontiers in Cellular Neuroscience, 2023
Microtubules are dynamic cytoskeletal structures involved in several cellular functions, such as intracellular trafficking, cell division and motility.
Riccardo Zocchi, Emanuele Bellacchio, Michela Piccione, Raffaella Scardigli, Raffaella Scardigli, Valentina D’Oria, Stefania Petrini, Kristin Baranano, Enrico Bertini, Antonella Sferra   +9 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Molecular motors and nuclear movements in muscle

Communicative & Integrative Biology, 2017
Muscle fibers have the particularity of containing numerous nuclei evenly distributed and positioned next to the plasma membrane. This unique disposition is the result of sequential events of nuclear movements that start when myoblasts fuse together and ...
E. R. Gomes, B. Cadot
doaj   +1 more source

Tubulins in C. elegans [PDF]

, 2018
The C. elegans tubulin family is composed of nine α-, six β-, and one γ-tubulin. Tubulins are highly conserved, functioning as α-β heterodimers that assemble into microtubules.
Hurd, Daryl D.
core   +2 more sources

Microtubule Acetylation Controls MDA-MB-231 Breast Cancer Cell Invasion through the Modulation of Endoplasmic Reticulum Stress [PDF]

, 2021
Panseon Ko, Jee‐Hye Choi, Seongeun Song, Seula Keum, Jangho Jeong, Ye Eun Hwang, Jung Woong Kim, Sangmyung Rhee   +7 more
openalex   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Conformational Dynamics and Thermal Cones of C-terminal Tubulin Tails in Neuronal Microtubules [PDF]

, 2007
In this paper we present a model for estimation of the C-terminal tubulin tail (CTT) dynamics in cytoskeletal microtubules of nerve cells. We show that the screened Coulomb interaction between a target CTT and the negatively charged microtubule surface ...
Georgiev, Danko, Glazebrook, James
core   +1 more source

Microtubules, microtubule-interfering agents and apoptosis

Apoptosis, 2003
Microtubules are dynamic polymers that play crucial roles in a large number of cellular functions. Their pivotal role in mitosis makes them a target for the development of anticancer drugs. Microtubule-damaging agents suppress microtubule dynamics, leading to disruption of the mitotic spindle in dividing cells, cell cycle arrest at M phase, and late ...
Mollinedo, Faustino, Gajate, Consuelo
openaire   +3 more sources