Results 61 to 70 of about 417,156 (275)
Phase separation of TPX2 enhances and spatially coordinates microtubule nucleation
Nature Communications, 2019 Phase separation of substrates and effectors is proposed to enhance biological reaction rates and efficiency. Targeting protein for Xklp2 (TPX2) is an effector of branching microtubule nucleation in spindles and functions with the substrate tubulin by an
Matthew R. King, Sabine Petry
semanticscholar +1 more source
The Arabidopsis Book, 2015 Microtubules (MTs) are highly conserved polar polymers that are key elements of the eukaryotic cytoskeleton and are essential for various cell functions. αβ-tubulin, a heterodimer containing one structural GTP and one hydrolysable and exchangeable GTP, is the building block of MTs and is formed by the sequential action of several molecular chaperones ...
openaire +3 more sources
eLife, 2015 The congression of chromosomes to the spindle equator involves the directed motility of bi-orientated sister kinetochores. Sister kinetochores bind bundles of dynamic microtubules and are physically connected through centromeric chromatin.
Nigel J Burroughs +2 more
doaj +1 more source
Monitoring Microtubule Mechanical Vibrations via Optomechanical Coupling
, 2016 The possible disruption of a microtubule during mitosis can control the duplication of a cancer cell. Cancer detection and treatment may be possible based on the detection and control of microtubule mechanical oscillations in cells through external ...
Barzanjeh, Sh. +4 more
core +1 more source
Directional instability of microtubule transport in the presence of kinesin and dynein, two opposite polarity motor proteins. [PDF]
, 1992 Kinesin and dynein are motor proteins that move in opposite directions along microtubules. In this study, we examine the consequences of having kinesin and dynein (ciliary outer arm or cytoplasmic) bound to glass surfaces interacting with the same ...
Brown, D, Malik, F, Vale, RD
core +2 more sources
Severing enzymes amplify microtubule arrays through lattice GTP-tubulin incorporation
Science, 2018 Severing to build microtubules Microtubules are essential intracellular polymers, built from tubulin subunits, that establish cell shape, move organelles, and segregate chromosomes during cell division. Vemu et al.
Annapurna Vemu +6 more
semanticscholar +1 more source
eLife, 2017 Purified microtubules have been shown to align along the static magnetic field (SMF) in vitro because of their diamagnetic anisotropy. However, whether mitotic spindle in mammalian cells can be aligned by magnetic field has not been experimentally proved.
Lei Zhang +12 more
doaj +1 more source
Regulation of Op18 during Spindle Assembly in Xenopus Egg Extracts [PDF]
, 2001 Oncoprotein 18 (Op18) is a microtubule-destabilizing protein that is negatively regulated by phosphorylation. To evaluate the role of the three Op18 phosphorylation sites in Xenopus (Ser 16, 25, and 39), we added wild-type Op18, a nonphosphorylatable ...
Andersen +67 more
core +4 more sources
Cell proliferation, cell shape, and microtubule and cellulose microfibril organization of tobacco BY-2 cells are not altered by exposure to near weightlessness in space [PDF]
, 2009 The microtubule cytoskeleton and the cell wall both play key roles in plant cell growth and division, determining the plant’s final stature. At near weightlessness, tubulin polymerizes into microtubules in vitro, but these microtubules do not self ...
Emons, A.M.C. +4 more
core +3 more sources
Developmental Dynamics, 2018 Classical microtubule‐associated proteins (MAPs) were originally identified based on their co‐purification with microtubules assembled from mammalian brain lysate.
Amrita Ramkumar +2 more
semanticscholar +1 more source