Results 61 to 70 of about 397,871 (335)

Phosphorylation of Spastin Promotes the Surface Delivery and Synaptic Function of AMPA Receptors

Frontiers in Cellular Neuroscience, 2022
Synaptic plasticity is essential for cognitive functions such as learning and memory. One of the mechanisms involved in synaptic plasticity is the dynamic delivery of AMPA receptors (AMPARs) in and out of synapses.
Li Chen, Hanjie Wang, Shuhan Cha, Jiong Li, Jiaqi Zhang, Jiaming Wu, Jiaming Wu, Guoqing Guo, Jifeng Zhang   +8 more
doaj   +1 more source

Microtubules in Plants [PDF]

The Arabidopsis Book, 2015
Microtubules (MTs) are highly conserved polar polymers that are key elements of the eukaryotic cytoskeleton and are essential for various cell functions. αβ-tubulin, a heterodimer containing one structural GTP and one hydrolysable and exchangeable GTP, is the building block of MTs and is formed by the sequential action of several molecular chaperones ...
openaire   +3 more sources

Are microtubules tension sensors? [PDF]

Nature Communications, 2019
AbstractMechanical signals play many roles in cell and developmental biology. Several mechanotransduction pathways have been uncovered, but the mechanisms identified so far only address the perception of stress intensity. Mechanical stresses are tensorial in nature, and thus provide dual mechanical information: stress magnitude and direction.
Hamant, Olivier, Inoue, Daisuke, Bouchez, David, Dumais, Jacques, Mjolsness, Eric   +4 more
openaire   +7 more sources

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Molecular Mechanisms for Microtubule Length Regulation by Kinesin-8 and XMAP215 Proteins

, 2014
The cytoskeleton is regulated by a plethora of enzymes that influence the stability and dynamics of cytoskeletal filaments. Molecular motors of the kinesin-8 protein family depolymerise microtubules in a length-dependent manner, and experimental and ...
Frey, Erwin, Melbinger, Anna, Reese, Louis   +2 more
core   +1 more source

Modeling oscillatory Microtubule--Polymerization [PDF]

, 2002
Polymerization of microtubules is ubiquitous in biological cells and under certain conditions it becomes oscillatory in time. Here simple reaction models are analyzed that capture such oscillations as well as the length distribution of microtubules.
A. Desai, A. Hyman, A. Marx, A. Suzuki, A.C. Newell, A.L. Hitt, B. Houchmandzadeh, C.M. Coppin, D. Sept, D.K. Fygenson, E. Jobs, E. Mandelkow, E.-M. Mandelkow, E.M. Mandelkow, F. Pirolet, F.J. Nedelec, G. Lange, G.J. Vroege, H. Flyvbjerg, H. Oberman, I. Aranson, J. Käs, J. Tabony, J. Tabony, J. Tabony, J. Tabony, L. Onsager, M. Dogterom, M.C. Cross, M.F. Carlier, N. Caudron, O. Valiron, R. Furukawa, R. Melki, R. Wade, T. Surrey, T.J. Mitchison, T.J. Mitchison, W. Schöpf, Y. Chen   +39 more
core   +2 more sources

Asymmetric Centriole Numbers at Spindle Poles Cause Chromosome Missegregation in Cancer

Cell Reports, 2017
Chromosomal instability is a hallmark of cancer and correlates with the presence of extra centrosomes, which originate from centriole overduplication. Overduplicated centrioles lead to the formation of centriole rosettes, which mature into supernumerary ...
Marco R. Cosenza, Anna Cazzola, Annik Rossberg, Nicole L. Schieber, Gleb Konotop, Elena Bausch, Alla Slynko, Tim Holland-Letz, Marc S. Raab, Taronish Dubash, Hanno Glimm, Sven Poppelreuther, Christel Herold-Mende, Yannick Schwab, Alwin Krämer   +14 more
doaj   +1 more source

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

Microtubules and motors [PDF]

Molecular Biology of the Cell, 2012
New tools and approaches are providing exciting new insights into the structure and function of motors and microtubules and their contributions to cell migration, mitosis, and neuronal function. Janel Titus, from the Wadsworth laboratory (University of Massachusetts, Amherst), discussed the regulation of the plus end–directed mitotic motor Eg5 by ...
Jonathon Howard, Pat Wadsworth
openaire   +1 more source

Microtubule self-repair

Current Opinion in Cell Biology, 2021
The stochastic switching between microtubule growth and shrinkage is a fascinating and unique process in the regulation of the cytoskeleton. To understand it, almost all attention has been focused on the microtubule ends. However, recent research has revived the idea that tubulin dimers can also be exchanged in protofilaments along the microtubule ...
Manuel Théry, Manuel Théry, Laurent Blanchoin, Laurent Blanchoin   +3 more
openaire   +4 more sources