Results 41 to 50 of about 228,374 (345)
SSNA1 stabilizes dynamic microtubules and detects microtubule damage [PDF]
eLife, 2021 Sjögren’s syndrome nuclear autoantigen-1 (SSNA1/NA14) is a microtubule-associated protein with important functions in cilia, dividing cells, and developing neurons. However, the direct effects of SSNA1 on microtubules are not known. We employed in vitro reconstitution with purified proteins and TIRF microscopy to investigate the activity of human SSNA1
Elizabeth J Lawrence +3 more
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Monitoring Microtubule Mechanical Vibrations via Optomechanical Coupling [PDF]
Phys. Rev. E 96, 012404 (2017), 2016 The possible disruption of a microtubule during mitosis can control the duplication of a cancer cell. Cancer detection and treatment may be possible based on the detection and control of microtubule mechanical oscillations in cells through external fields (e.g. electromagnetic or ultrasound).
arxiv +1 more source
Journal of Biological Research - Thessaloniki, 2021 Background Cortical microtubules regulate cell expansion by determining cellulose microfibril orientation in the root apex of Arabidopsis thaliana. While the regulation of cell wall properties by cortical microtubules is well studied, the data on the ...
Veronica Giourieva, Emmanuel Panteris
doaj +1 more source
Molecular Biology of the Cell, 2018 The Minisymposium “The Life of a Microtubule: Birth, Dynamics and Function” highlighted new findings on how microtubules (MTs) are made, how their length and spatial organization is regulated, and finally how they contribute to cellular functions.
Dixit, Ram, Petry, Sabine
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The role of microtubule movement in bidirectional organelle transport [PDF]
Proc. Nat. Acad. Sci. (2008) 105:10011-10016, 2008 We study the role of microtubule movement in bidirectional organelle transport in Drosophila S2 cells and show that EGFP-tagged peroxisomes in cells serve as sensitive probes of motor induced, noisy cytoskeletal motions. Multiple peroxisomes move in unison over large time windows and show correlations with microtubule tip positions, indicating rapid ...
arxiv +1 more source
CLASP promotes microtubule bundling in metaphase spindle independently of Ase1/PRC1 in fission yeast
Biology Open, 2019 Microtubules in the mitotic spindle are organised by microtubule-associated proteins. In the late stage of mitosis, spindle microtubules are robustly organised through bundling by the antiparallel microtubule bundler Ase1/PRC1. In early mitosis, however,
Hirohisa Ebina, Liang Ji, Masamitsu Sato
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Microtubules born on microtubules
The Journal of Cell Biology, 2005 ![Graphic][1] A new MT is nucleated (white arrowhead) by a γ-TuC (green) that sits on an existing MT bundle.Microtubule (MT) arrays form, say Janson et al. ( [page 297][2]), when MT nucleators stick to existing MTs.
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Are microtubules tension sensors? [PDF]
Nature Communications, 2019 AbstractMechanical signals play many roles in cell and developmental biology. Several mechanotransduction pathways have been uncovered, but the mechanisms identified so far only address the perception of stress intensity. Mechanical stresses are tensorial in nature, and thus provide dual mechanical information: stress magnitude and direction.
Hamant, Olivier +4 more
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The Arabidopsis Book, 2015 Microtubules (MTs) are highly conserved polar polymers that are key elements of the eukaryotic cytoskeleton and are essential for various cell functions. αβ-tubulin, a heterodimer containing one structural GTP and one hydrolysable and exchangeable GTP, is the building block of MTs and is formed by the sequential action of several molecular chaperones ...
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Microtubule Defects Influence Kinesin-Based Transport In Vitro [PDF]
Biophysical Journal , Volume 110 , Issue 10 , 2229 - 2240 (2016), 2016 Microtubules are protein polymers that form "molecular highways" for long-range transport within living cells. Molecular motors actively step along microtubules to shuttle cellular materials between the nucleus and the cell periphery; this transport is critical for the survival and health of all eukaryotic cells.
arxiv +1 more source