Results 41 to 50 of about 225,378 (345)
CLASP promotes microtubule bundling in metaphase spindle independently of Ase1/PRC1 in fission yeast
Biology Open, 2019 Microtubules in the mitotic spindle are organised by microtubule-associated proteins. In the late stage of mitosis, spindle microtubules are robustly organised through bundling by the antiparallel microtubule bundler Ase1/PRC1. In early mitosis, however,
Hirohisa Ebina, Liang Ji, Masamitsu Sato
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A Stochastic Multiscale Model That Explains the Segregation of Axonal Microtubules and Neurofilaments in Neurological Diseases. [PDF]
PLoS Computational Biology, 2015 The organization of the axonal cytoskeleton is a key determinant of the normal function of an axon, which is a long thin projection of a neuron.
Chuan Xue, Blerta Shtylla, Anthony Brown
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Kinetically distinct phases of tau on microtubules regulate kinesin motors and severing enzymes
Nature Cell Biology, 2018 Tau is an intrinsically disordered protein, which diffuses on microtubules1. In neurodegenerative diseases, collectively termed tauopathies, malfunction of tau and its detachment from axonal microtubules are correlated with axonal degeneration2.
Valerie Siahaan +6 more
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Molecular Biology of the Cell, 2018 The Minisymposium “The Life of a Microtubule: Birth, Dynamics and Function†highlighted new findings on how microtubules (MTs) are made, how their length and spatial organization is regulated, and finally how they contribute to cellular functions.
Dixit, Ram, Petry, Sabine
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Journal of Biological Research - Thessaloniki, 2021 Background Cortical microtubules regulate cell expansion by determining cellulose microfibril orientation in the root apex of Arabidopsis thaliana. While the regulation of cell wall properties by cortical microtubules is well studied, the data on the ...
Veronica Giourieva, Emmanuel Panteris
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Tau stabilizes microtubules by binding at the interface between tubulin heterodimers
Proceedings of the National Academy of Sciences of the United States of America, 2015 Significance Tau is an important microtubule-associated protein. Although the structure–function relationship of Tau has been intensively studied for many years primarily by molecular biology and biochemical approaches, little is still known about the ...
Harindranath Kadavath +7 more
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Microtubules born on microtubules
The Journal of Cell Biology, 2005 ![Graphic][1] A new MT is nucleated (white arrowhead) by a γ-TuC (green) that sits on an existing MT bundle.Microtubule (MT) arrays form, say Janson et al. ( [page 297][2]), when MT nucleators stick to existing MTs.
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Taxol stabilizes microtubules in mouse fibroblast cells.
Proceedings of the National Academy of Sciences of the United States of America, 1980 Taxol, a potent inhibitor of human HeLa and mouse fibroblast cell replication, blocked cells in the G2 and M phase of the cell cycle and stabilized cytoplasmic microtubules.
P. Schiff, S. Horwitz
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eLife, 2018 Presence of multiple copies of the microtubule-binding NDC80 complex is an evolutionary conserved feature of kinetochores, points of attachment of chromosomes to spindle microtubules.
Vladimir A Volkov +3 more
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Nature Communications, 2016 Neurons display a highly polarized microtubule network that mediates trafficking throughout the extensive cytoplasm and is crucial for neuronal differentiation and function.
Carlos Sánchez-Huertas +5 more
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