Results 51 to 60 of about 225,378 (345)
The Arabidopsis Book, 2015 Microtubules (MTs) are highly conserved polar polymers that are key elements of the eukaryotic cytoskeleton and are essential for various cell functions. αβ-tubulin, a heterodimer containing one structural GTP and one hydrolysable and exchangeable GTP, is the building block of MTs and is formed by the sequential action of several molecular chaperones ...
openaire +3 more sources
eLife, 2015 In this study, we investigated how microtubule motors organize microtubules in Drosophila neurons. We showed that, during the initial stages of axon outgrowth, microtubules display mixed polarity and minus-end-out microtubules push the tip of the axon ...
Urko del Castillo +3 more
doaj +1 more source
Journal of Neuroscience, 2016 In cultured vertebrate neurons, axons have a uniform arrangement of microtubules with plus-ends distal to the cell body (plus-end-out), whereas dendrites contain mixed polarity orientations with both plus-end-out and minus-end-out oriented microtubules ...
K. Yau +6 more
semanticscholar +1 more source
New Journal of Physics, 2018 Spindles are self-organized microtubule-based structures that segregate chromosomes during cell division. The mass of the spindle is controlled by the balance between microtubule turnover and nucleation. The mechanisms that control the spatial regulation
Bryan Kaye +5 more
doaj +1 more source
Microtubules self-repair in response to mechanical stress
Nature Materials, 2015 Microtubules - which define the shape of axons, cilia and flagella, and provide tracks for intracellular transport - can be highly bent by intracellular forces, and microtubule structure and stiffness are thought to be affected by physical constraints ...
Laura Schaedel +5 more
semanticscholar +1 more source
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Kinesin-propelled label-free microtubules imaged with interference reflection microscopy
New Journal of Physics, 2020 Interference reflection microscopy (IRM) utilizes the interference between the light reflected from the surface and the light reflected from an object to generate contrast and can be used to image nanometer size objects, such as a microtubule adhered to ...
Gadiel Saper, Henry Hess
doaj +1 more source
Microtubules in Polyomavirus Infection
Viruses, 2020 Microtubules, part of the cytoskeleton, are indispensable for intracellular movement, cell division, and maintaining cell shape and polarity. In addition, microtubules play an important role in viral infection.
Lenka Horníková +2 more
doaj +1 more source
Detyrosinated microtubules modulate mechanotransduction in heart and skeletal muscle
Nature Communications, 2015 In striated muscle, X-ROS is the mechanotransduction pathway by which mechanical stress transduced by the microtubule network elicits reactive oxygen species.
J. P. Kerr +11 more
semanticscholar +1 more source
FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source