Results 21 to 30 of about 132,725 (259)

Systemic microvascular dysfunction in microvascular and vasospastic angina [PDF]

European Heart Journal, 2018
Coronary microvascular dysfunction and/or vasospasm are potential causes of ischaemia in patients with no obstructive coronary artery disease (INOCA). We tested the hypothesis that these patients also have functional abnormalities in peripheral small arteries.Patients were prospectively enrolled and categorised as having microvascular angina (MVA ...
Ford, Thomas J., Rocchiccioli, Paul, Good, Richard, McEntegart, Margaret, Eteiba, Hany, Watkins, Stuart, Shaukat, Aadil, Lindsay, Mitchell, Robertson, Keith, Hood, Stuart, Yii, Eric, Sidik, Novalia, Harvey, Adam, Montezano, Augusto C., Beattie, Elisabeth, Haddow, Laura, Oldroyd, Keith G., Touyz, Rhian M., Berry, Colin   +18 more
openaire   +3 more sources

MiR-30 promotes fatty acid beta-oxidation and endothelial cell dysfunction and is a circulating biomarker of coronary microvascular dysfunction in pre-clinical models of diabetes

Cardiovascular Diabetology, 2022
Background Type 2 diabetes (T2D) is associated with coronary microvascular dysfunction, which is thought to contribute to compromised diastolic function, ultimately culminating in heart failure with preserved ejection fraction (HFpEF).
Shawn Veitch, Makon-Sébastien Njock, Mark Chandy, M. Ahsan Siraj, Lijun Chi, HaoQi Mak, Kai Yu, Kumaragurubaran Rathnakumar, Carmina Anjelica Perez-Romero, Zhiqi Chen, Faisal J. Alibhai, Dakota Gustafson, Sneha Raju, Ruilin Wu, Dorrin Zarrin Khat, Yaxu Wang, Amalia Caballero, Patrick Meagher, Edward Lau, Lejla Pepic, Henry S. Cheng, Natalie J. Galant, Kathryn L. Howe, Ren-Ke Li, Kim A. Connelly, Mansoor Husain, Paul Delgado-Olguin, Jason E. Fish   +27 more
doaj   +1 more source

Fluoroscopic methods of assessment of coronary microvascular dysfunction – a review of literature [PDF]

Българска кардиология
A large proportion of patients with angina and evidence of myocardial ischemia do not have obstructive coronary disease. One of the main mechanisms of ischemia/angina with non-obstructive coronary arteries is coronary microvascular dysfunction, which is ...
R. Grigorov, S. Yambolov
doaj   +3 more sources

Capillary function progressively deteriorates in prodromal Alzheimer’s disease: A longitudinal MRI perfusion study

Aging Brain, 2022
Cardiovascular risk factors are associated with the development of Alzheimer’s disease (AD), and increasing evidence suggests that cerebral microvascular dysfunction plays a vital role in the disease progression.
Lasse S. Madsen, Rune B. Nielsen, Peter Parbo, Rola Ismail, Irene K. Mikkelsen, Hanne Gottrup, Leif Østergaard, David J. Brooks, Simon F. Eskildsen   +8 more
doaj   +1 more source

International prospective cohort study of microvascular angina – Rationale and design

International Journal of Cardiology: Heart & Vasculature, 2020
Background: Patients with signs and symptoms of myocardial ischemia and non-obstructive coronary artery disease (CAD) frequently have coronary functional abnormalities, including coronary microvascular dysfunction. Those with the latter are grouped under
Akira Suda, Jun Takahashi, John F. Beltrame, Colin Berry, Paolo G. Camici, Filippo Crea, Javier Escaned, Tom Ford, Juan Carlos Kaski, Takahiko Kiyooka, Puja K. Metha, Peter Ong, Yukio Ozaki, Carl Pepine, Ornella Rimoldi, Basmah Safdar, Udo Sechtem, Kenichi Tsujita, Eric Yii, C. Noel Bairey Merz, Hiroaki Shimokawa   +20 more
doaj   +1 more source

Microvascular Dysfunction and Cognitive Impairment [PDF]

Cellular and Molecular Neurobiology, 2016
The impact of vascular risk factors on cognitive function has garnered much interest in recent years. The appropriate distribution of oxygen, glucose, and other nutrients by the cerebral vasculature is critical for proper cognitive performance. The cerebral microvasculature is a key site of vascular resistance and a preferential target for small vessel
T Michael, De Silva, Frank M, Faraci
openaire   +2 more sources

Coronary microvascular dysfunction

Microvascular Research
Coronary microvascular dysfunction (CMD) is a key mechanism underlying ischemic heart disease (IHD), yet its diagnosis and treatment remain challenging. This article presents a comprehensive overview of CMD research, covering its pathogenesis, diagnostic criteria, assessment techniques, risk factors, and therapeutic strategies.
Chunlin, Zhu, Lina, Miao, Kangkang, Wei, Dazhuo, Shi, Jie, Gao   +4 more
  +8 more sources

Coronary microvascular dysfunction as a chronic inflammatory state: Is there a role for omega-3 fatty acid treatment?

American Heart Journal Plus, 2022
Coronary microvascular dysfunction is a ubiquitous pathologic process that is operational in ischemia with no obstructive coronary artery disease and other cardiovascular disorders including heart failure with preserved ejection fraction. It may, in fact,
Ellen C. Keeley, Eileen M. Handberg, Janet Wei, C. Noel Bairey Merz, Carl J. Pepine   +4 more
doaj   +1 more source

Pathophysiology of Coronary Microvascular Dysfunction

Circulation Journal, 2022
Ischemic heart disease (IHD) is commonly recognized as the consequence of coronary atherosclerosis and obstructive coronary artery disease (CAD). However, a significant number of patients may present angina or myocardial infarction even in the absence of any significant coronary artery stenosis and impairment of the coronary microcirculation has been ...
Crea, Filippo, Montone, Rocco A., Rinaldi, Riccardo   +2 more
openaire   +3 more sources

Neutrophil extracellular traps drive intestinal microvascular endothelial ferroptosis by impairing Fundc1-dependent mitophagy

Redox Biology, 2023
Microvascular endothelial damage caused by intestinal ischemia‒reperfusion (II/R) is a primary catalyst for microcirculation dysfunction and enterogenous infection.
Chengnan Chu, Xinyu Wang, Chao Yang, Fang Chen, Lin Shi, Weiqi Xu, Kai Wang, Baochen Liu, Chenyang Wang, Dongping Sun, Weiwei Ding   +10 more
doaj   +1 more source