Results 81 to 90 of about 19,869 (350)

Attack of the microvesicles

The Journal of Cell Biology, 2002
![Graphic][1] Melanoma cells can attack using microvesicles loaded with FasL (red). Fais/RUPMelanoma cells send out microvesicles loaded with Fas ligand (FasL) to kill their would-be assassins, according to Stefano Fais (Istituto Superiore di Sanita, Rome, Italy), Licia Rivoltini (
openaire   +2 more sources

Microvesicles : What's Plasma Made of? [PDF]

Biophysical Journal, 2014
Microvesicles (MVs) are cell-derived membrane fragments which are present in plasma and other body fluids. In plasma, MVs participate in physiological processes of hemostasis and inflammation. MVs contain cell-specific molecules and are present at elevated levels in various diseases, which has raised the hypothesis of their potential application as ...
Sisareuth Tan, Romain Linares, Nicolas Arraud, Alain Brisson, Céline Gounou   +4 more
openaire   +2 more sources

von Willebrand factor enhances microvesicle-induced vascular leakage and coagulopathy in mice with traumatic brain injury.

Blood, 2018
von Willebrand factor (VWF) is an adhesive ligand, and its activity is proteolytically regulated by the metalloprotease ADAMTS-13 (a disintegrin and metalloprotease with thrombospondin type 1 repeat 13).
Yingang Wu, Wei Liu, Yuan Zhou, Tristan Hilton, Zilong Zhao, W. Liu, Min Wang, Jason Yeon, Katie L. Houck, P. Thiagarajan, Fangyi Zhang, F. Shi, Xiaoping Wu, Min Li, Jing-fei Dong, Jian-ning Zhang   +15 more
semanticscholar   +1 more source

Elevated Levels of Procoagulant Microvesicles and Tissue-Factor Bearing Microvesicles in Malaria Patients

International Journal of General Medicine, 2023
Procoagulant microvesicles (MVs) are submicron membrane fragments released from activated cells and cells undergoing apoptosis. The procoagulant activity of MVs is enhanced in the presence of tissue factor (TF). MVs and TF are active mediators that induce pro-inflammatory response and prothrombotic tendency and have been linked to the severity of ...
Aymen M Madkhali, Abdullah A Mobarki, Ahmad H Ghzwani, Hesham M Al-Mekhlafi, Ahmed Zhranei, Abdulrahman Osais, Ahmed Sohel, Basim Othman, Gasim Dobie, Hassan A Hamali   +9 more
openaire   +4 more sources

Distinguishing functional exosomes and other extracellular vesicles as a nucleic acid cargo by the anion‐exchange method

Journal of Extracellular Vesicles, 2022
The development of a new large‐scale purification protocol is required for research on the reliable bioactivity and drug discovery of extracellular vesicles (EVs).
Naohiro Seo, Junko Nakamura, Tsuguhiro Kaneda, Hiroaki Tateno, Asako Shimoda, Takanori Ichiki, Koichi Furukawa, Jun Hirabayashi, Kazunari Akiyoshi, Hiroshi Shiku   +9 more
doaj   +1 more source

Sialic Acid Glycobiology Unveils Trypanosoma cruzi Trypomastigote Membrane Physiology. [PDF]

, 2016
Trypanosoma cruzi, the flagellate protozoan agent of Chagas disease or American trypanosomiasis, is unable to synthesize sialic acids de novo. Mucins and trans-sialidase (TS) are substrate and enzyme, respectively, of the glycobiological system that ...
A Acosta-Serrano, A Buschiazzo, A Egner, A Galetovic, Andrés B. Lantos, AS Couto, BB Diaz-Rohrer, Beatriz Araoz, CA Buscaglia, CA Buscaglia, Carlos A. Buscaglia, Carolyn R. Bertozzi, DC Bartholomeu, E Bayer-Santos, EJ Finkelsztein, G Bernabo, Giannina Carlevaro, GM Rocha, GM Rocha, GT Dempsey, H Yu, Hai Yu, HT McMahon, HT McMahon, I Levental, I Urban, IA Oliveira, IC Almeida, IC Almeida, J Folling, J Zimmerberg, JA Prescher, JA Prescher, JC Jewett, JH Lumb, JM Baskin, JM Di Noia, JM Di Noia, Juan Mucci, K Simons, KM Tyler, LM De Pablos, LM Freitas, M Hashimoto, Malcolm J. McConville, Mariano Bossi, María de los Milagros Camara, MdL Camara, ME Giorgi, MF Goncalves, MG Risso, ML Salto, MM Camargo, MS Leguizamón, MV Gudheti, NM Quanquin, NW Andrews, Oscar Campetella, P Ruiz Diaz, Pablo Ruiz Diaz, PN Ulrich, RE Thompson, RM de Lederkremer, RP Muiá, S Niyogi, S Schenkman, S Schenkman, S Schenkman, S Tomlinson, SS Rubin de Celis, T Furuya, TJ Gould, Torrecilhas AC Trocoli, U Frevert, V de Paulo Martins, V Jimenez, VA Campo, Vde P Martins, VL Pereira-Chioccola, W de Souza, W de Souza, WB Huttner, X Xu, Xi Chen   +83 more
core   +5 more sources

Thromboinflammatory effects of RBC microvesicles [PDF]

Blood, 2020
In this issue of Blood, Noubouossie et al provide new insights into potential mechanisms for thromboinflammatory complications associated with red blood cell (RBC) transfusions. By using leukoreduced RBC units to isolate RBC microvesicles (RBC-MVs), they document that RBC-MVs activate factor IX (FIX) via 2 distinct pathways: (1) the canonical ...
openaire   +3 more sources

ARRDC1 as a mediator of microvesicle budding [PDF]

Proceedings of the National Academy of Sciences, 2012
Eukaryotic cells critically depend on the formation, budding, and scission of membrane-bounded vesicles for many key processes: internalization of cell surface receptors, delivery of cargo proteins to multivesicular bodies (MVBs) and lysosomes for degradation, transport of newly synthesized proteins between intracellular organelles and their delivery ...
Lillian S. Kuo, Eric O. Freed
openaire   +2 more sources

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

The role of exosomes in peripheral nerve regeneration

Neural Regeneration Research, 2015
Peripheral nerve injuries remain problematic to treat, with poor functional recovery commonly observed. Injuries resulting in a nerve gap create specific difficulties for axonal regeneration.
Rosanna C Ching, Paul J Kingham
doaj   +1 more source