Results 81 to 90 of about 15,195 (308)
Neural Regeneration Research, 2015 Subarachnoid hemorrhage is frequently associated with poor prognoses. Three different hemodynamic phases were identified during subarachnoid hemorrhage: oligemia, hyperemia, and vasospasm. Each phase is associated with brain metabolic changes.
Marcelo de Lima Oliveira +5 more
doaj +1 more source
International Journal of Molecular Sciences, 2019 The blood-brain barrier (BBB), composed of brain microvascular endothelial cells (BMEC) that are tightly linked by tight junction (TJ) proteins, restricts the movement of molecules between the periphery and the central nervous system.
A. Ajikumar +6 more
semanticscholar +1 more source
Advanced Materials, EarlyView.Stem cell spheroids, produced via a high‐throughput microfabrication technique, are transported within a vortex generated at the outlet channels of a cross‐slot millifluidic chip. For Reynolds number exceeding 170–200, intermittent high shear stresses applied to each spheroid within the vortex trigger a massive release of biologically active ...
Elliot Thouvenot +8 more
wiley +1 more source
Molecular Neurodegeneration, 2016 BackgroundDespite the clear physical association between activated astrocytes and amyloid-β (Aβ) plaques, the importance of astrocytes and their therapeutic potential in Alzheimer’s disease remain elusive.
Sofia Söllvander +6 more
semanticscholar +1 more source
Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting
Advanced Materials, EarlyView.CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu +4 more
wiley +1 more source
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
Circulating Extracellular Vesicles and Endothelial Damage in Sickle Cell Disease
Frontiers in Physiology, 2020 Endothelial damage is central to the pathogenesis of many of the complications of sickle cell disease. Circulating extracellular vesicles (EVs) have been implicated in modulating endothelial behavior in a variety of different, diseases with vascular ...
Gabrielle Lapping-Carr +3 more
doaj +1 more source
Journal of Extracellular Vesicles, 2022 The development of a new large‐scale purification protocol is required for research on the reliable bioactivity and drug discovery of extracellular vesicles (EVs).
Naohiro Seo +9 more
doaj +1 more source
Nanoscale Phytosomes as an Emerging Modality for Cancer Therapy
Cells, 2023 Extracellular vesicle (EV) research has expanded substantially over the years. EVs have been identified in all living organisms and are produced and released as a means of intercellular communication or as a defense mechanism.
Ahmad Kadriya, Mizied Falah
doaj +1 more source
Platelet microvesicles in health and disease
Platelets, 2017 Interest in cell-derived extracellular vesicles and their physiological and pathological implications is constantly growing. Microvesicles, also known as microparticles, are small extracellular vesicles released by cells in response to activation or apoptosis.
Eric Boilard +3 more
openaire +3 more sources