Results 91 to 100 of about 8,491 (234)

Renal‐vascular axis: unmasking its role in vascular endothelial growth factor‐inhibitor vascular toxicity in cancer patients

British Journal of Pharmacology, EarlyView.
Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley   +1 more source

RAB4A acts as a negative feedback regulator of extracellular vesicle secretion during TGF‐β signaling

The FEBS Journal, EarlyView.
TGF‐β signaling regulates extracellular vesicle (EV) release in cancer cells by modulating the expression and activity of genes associated with EV biogenesis. The TGF‐β‐induced upregulation of RAB4A expression facilitates fast endosomal recycling, a process that limits the fusion of multivesicular bodies with the plasma membrane and EV secretion. Hence,
Dorival Mendes Rodrigues‐Junior, Maria Anastasia Doumani, Hao Fu, Jelle van den Bor, Olof Idevall‐Hagren, Aristidis Moustakas   +5 more
wiley   +1 more source

Biogenesis of TNF‐α‐insights into proteostasis and inflammation

The FEBS Journal, EarlyView.
TNF‐α biogenesis, trafficking, and signalling are tightly and reciprocally coupled to cellular proteostasis systems, including ER chaperones and endoplasmic reticulum‐associated degradation. This bidirectional crosstalk determines whether TNF‐α responses are adaptive or proteotoxic.
Bailasan Haidar, Céline Philippe, Eric Chevet, Jiří Zahradník   +3 more
wiley   +1 more source

Extracellular Vesicle: An Emerging Mediator of Intercellular Crosstalk in Lung Inflammation and Injury

Frontiers in Immunology, 2018
Inflammatory lung responses are one of the characterized features in the pathogenesis of many lung diseases, including acute respiratory distress syndrome (ARDS) and chronic obstructive pulmonary disease (COPD).
Heedoo Lee, Eric Abston, Duo Zhang, Ashish Rai, Yang Jin   +4 more
doaj   +1 more source

Mast Cells Selectively Deliver Extracellular Vesicle‐Encapsulated mRNA to Colorectal Cancer Cells

Immunology &Cell Biology, EarlyView.
Schematic overview of mast cell‐colorectal cancer cell interactions. Mast cells bind to colorectal cancer cells through integrin‐mediated adhesion (1). Calcium influx arises in mast cells (2). Calcium signaling is required for the release of mRNA‐ and protein‐containing vesicles (3), resulting in the transfer of mast cell‐derived mRNA and proteins to ...
Rosie Lanzloth, Bader El Farran, Ram Podicheti, Douglas B. Rusch, Heather M. O'Hagan   +4 more
wiley   +1 more source

Extracellular vesicles in multiple sclerosis: what are they telling us?

Frontiers in Cellular Neuroscience, 2014
Extracellular vesicles (EVs) are membrane-bound particles secreted by almost all cell types. They are classified depending on their biogenesis and size into exosomes and microvesicles or according to their cell origin.
Matías eSáenz-Cuesta, Matías eSáenz-Cuesta, Iñaki eOsorio-Querejeta, Iñaki eOsorio-Querejeta, David eOtaegui, David eOtaegui   +5 more
doaj   +1 more source

The Imbalance Between Tumor Immunosurveillance and Tumor Immune Escape in Glioblastoma

Immunology &Cell Biology, EarlyView.
(Left)The identification and elimination of tumour cells is enabled by the infiltration of functional innate and adaptive immune effectors into the TME, such as natural killer cells (NK cells) and cytotoxic T cells (CD8 T cells). Effective innate and adaptive immune responses facilitate immunological control of malignant outgrowth.
Sarah J. MacDonald, Matthew Drill, Padmakrishnan C. Jayakrishnan, Richard P. Sequeira, Terence J. O'Brien, Rosalind L. Jeffree, Mastura Monif   +6 more
wiley   +1 more source

Plasma Membrane Lipid Domains as Platforms for Vesicle Biogenesis and Shedding?

Biomolecules, 2018
Extracellular vesicles (EVs) contribute to several pathophysiological processes and appear as emerging targets for disease diagnosis and therapy. However, successful translation from bench to bedside requires deeper understanding of EVs, in particular ...
Hélène Pollet, Louise Conrard, Anne-Sophie Cloos, Donatienne Tyteca   +3 more
doaj   +1 more source

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

Journal of Periodontal Research, EarlyView.
The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag, Magdalena Mayol, Danijel Domic, Madhusudhan Reddy Bobbili, Johannes Grillari, Mariano Sanz, Reinhard Gruber   +6 more
wiley   +1 more source

Urinary microvesicles: a window into the kidney

Clinical Kidney Journal
ABSTRACT Chronic kidney disease (CKD) is a growing concern in aging populations. CKD is characterized by two hallmark symptoms: a decline in the glomerular filtration rate (GFR) and albuminuria. Early changes in kidney function are notoriously underdiagnosed, suggesting the need for new noninvasive diagnostic and prognostic biomarkers of
Luisa Schnobrich, Hayo Castrop
openaire   +3 more sources