Results 141 to 150 of about 59,785 (337)

Intravascular hemolysis activates complement via cell-free heme and heme-loaded microvesicles.

JCI Insight, 2018
In hemolytic diseases, such as sickle cell disease (SCD), intravascular hemolysis results in the release of hemoglobin, heme, and heme-loaded membrane microvesicles in the bloodstream.
N. Merle, Anne Grunenwald, Helena Rajaratnam, V. Gnemmi, Marie Frimat, Marie-Lucile Figueres, Samantha Knockaert, Sanah Bouzekri, D. Charue, Rémi Noé, Tania Robe-Rybkine, Marie Le-Hoang, Nathan Brinkman, Thomas Gentinetta, M. Edler, S. Petrillo, E. Tolosano, S. Miescher, S. Le Jeune, P. Houillier, S. Chauvet, M. Rabant, J. Dimitrov, V. Frémeaux-Bacchi, O. Blanc-Brude, L. Roumenina   +25 more
semanticscholar   +1 more source

Extracellular Vesicles in Calcium Oxalate Nephrolithiasis: Emerging Biomarkers and Therapeutic Potential

Advanced NanoBiomed Research, EarlyView.
Kidney stones cause significant pain and healthcare costs. Current prediction, diagnosis, and treatment options are limited. Extracellular vesicles (EVs), rich in proteins, lipids, and nucleic acids, offer a promising solution. This review explores the roles of EVs in kidney stone management, highlighting their potential as biomarkers and therapeutic ...
Wang Zhu, Xu Changzhi, Deng Qiong, Liang Hui   +3 more
wiley   +1 more source

MicroRNA-21 over expression in umbilical cord blood hematopoietic stem progenitor cells by leukemia microvesicles

Genetics and Molecular Biology
Microvesicles are able to induce the cell of origin’s phenotype in a target cell. MicroRNA-21, as an oncomir, is up-regulated in almost all cancer types such as leukemia which results in cell proliferation.
Farnaz Razmkhah, Masoud Soleimani, Sorayya Ghasemi, Sedigheh Amini Kafi-abad   +3 more
doaj   +1 more source

Thrombin generation assay and transmission electron microscopy: a useful combination to study tissue factor-bearing microvesicles

Journal of Extracellular Vesicles, 2013
Introduction. Patients with cancer have a 7- to 10-fold increased risk of developing venous thromboembolism. Circulating microvesicles could be a useful predictive biomarker for venous thromboembolism in cancer. Validated and standardised techniques that
Damien Gheldof, Julie Hardij, Francesca Cecchet, Bernard Chatelain, Jean-Michel Dogné, François Mullier   +5 more
doaj   +1 more source

Integration of maternal genome into the neonate genome through breast milk mRNA transcripts and reverse transcriptase [PDF]

, 2012
Human milk samples contain microvesicles similar to the retroviruses. These microvesicles contain mRNA transcripts and possess reverse transcriptase activity. They contain about 14,000 transcripts representing the milk transcriptome.
Emin Oztas, M Irmak, Yesim Oztas
core   +1 more source

Exosomes in Intervertebral Disc Regeneration: Roles, Opportunities, and Challenges

Advanced NanoBiomed Research, EarlyView.
Factors of Intervertebral Disc Degeneration Extracellular Matrix (ECM) Exosomes and Intervertebral Disc Degeneration (IVDD) Exosome‐Mediated Therapy for IVDD of Different Cell Sources Application of Engineered Exosomes in IVDD Clinical Application of Exosomes in IVDD Treatment Conclusion and Future Perspectives. Intervertebral disc degeneration (IVDD),
Xianglong Zhou, Tianyi Xia, Jiheng Xiao, Jianhui Xiang, Hanhong Fang, Haoran Zhou, Yiqiang Hu, Liming Xiong   +7 more
wiley   +1 more source

Synovial Sarcoma Microvesicles Harbor the SYT-SSX Fusion Gene Transcript: Comparison of Different Methods of Detection and Implications in Biomarker Research

Stem Cells International, 2016
Background. Synovial sarcoma is an aggressive soft-tissue malignancy. This study examines the presence of the SYT-SSX fusion transcript in synovial sarcoma microvesicles as well as its potential role as a biomarker for synovial sarcoma.
A. Fricke, P. V. Ullrich, A. F. V. Cimniak, M. Follo, S. Nestel, B. Heimrich, I. Nazarenko, G. B. Stark, H. Bannasch, D. Braig, S. U. Eisenhardt   +10 more
doaj   +1 more source

Activation of endothelial pro-resolving anti-inflammatory pathways by circulating microvesicles from non-muscular myosin light chain kinase-deficient mice

Frontiers in Pharmacology, 2016
Microvesicles, small membrane vesicles released from cells, have beneficial and/or deleterious effects in sepsis. We previously reported that non-muscle myosin light chain kinase (nmMLCK) deletion protects mice against endotoxic shock by reducing ...
Abderahim Gaceb, Luisa Vergori, M Carmen Martínez, Ramaroson Andriantsitoaina   +3 more
doaj   +1 more source

Non-Coding RNA Sequencing of Equine Endometrium During Maternal Recognition of Pregnancy. [PDF]

, 2019
Maternal recognition of pregnancy (MRP) in the mare is not well defined. In a non-pregnant mare, prostaglandin F2α (PGF) is released on day 14 post-ovulation (PO) to cause luteal regression, resulting in loss of progesterone production. Equine MRP occurs
Bouma, Gerrit J, Bruemmer, Jason E, Cameron, Ashley D, Canovas, Angela, Coleman, Stephen J, Hess, Ann M, Islas-Trejo, Alma D, Kalbfleisch, Ted, Klohonatz, Kristin M, Medrano, Juan F, Reed, Kailee J   +10 more
core   +1 more source

Efficient scalable production of therapeutic microvesicles derived from human mesenchymal stem cells

Scientific Reports, 2018
Microvesicles (MVs) released by cells are involved in a multitude of physiological events as important mediators of intercellular communication. MVs derived from mesenchymal stem cells (MSCs) contain various paracrine factors from the cells that ...
J. Cha, Eun Kyoung Shin, J. Sung, Gyeong Joon Moon, E. Kim, Y. Cho, HyungDal Park, Hojae Bae, Jinseok Kim, O. Bang   +9 more
semanticscholar   +1 more source