Secretome Profiling in Axon Regeneration: Emerging Techniques and Therapeutic Translation
Sensory Neuroscience, EarlyView.ABSTRACT The secretome refers to the in vivo ensemble of molecular entities that are found in interstitial spaces. It is then the mere secreted products of the cells, as all biomolecules in the interstitial cellular spaces also undergo modifications. The fractionated secretome may hold potential as a cell‐free therapy option due to its role in tissue ...
Maria D. Cabrera +3 more
wiley +1 more source
Human Colorectal Cancer Cells Induce T-Cell Death Through Release of Proapoptotic Microvesicles: Role in Immune Escape [PDF]
, 2005 Veronica Huber +16 more
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Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing
Small, EarlyView.The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa +4 more
wiley +1 more source
Small Methods, EarlyView.Schematic illustration of the current study. A) Multiple cell culture media are used for HUVEC cultures under both static and flow conditions. Cells are analyzed for morphology, endothelial markers, and gene expression. B) EVs are isolated from static and flow HUVEC cultures, and investigated for particle characterization, transcriptome and proteome ...
Arefeh Kardani +13 more
wiley +1 more source
Snakebites and microvesicles: Popping bubbles [PDF]
Research and Practice in Thrombosis and Haemostasis, 2019 Bos, M.H.A., Versteeg, H.H.
openaire +4 more sources
EBioMedicine, 2019 Background: The complement and kallikrein-kinin systems (KKS) are activated during vascular inflammation. The aim of this study was to investigate if blockade of the KKS can affect complement activation on the endothelium during inflammation.
Ingrid Lopatko Fagerström +10 more
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Human Tumor-Released Microvesicles Promote the Differentiation of Myeloid Cells with Transforming Growth Factor-β–Mediated Suppressive Activity on T Lymphocytes [PDF]
, 2006 Roberta Valenti +9 more
openalex +1 more source
Small Methods, EarlyView.This review explores the dual roles of exosomes in gastrointestinal (GI) cancers as diagnostic biomarkers and therapeutic agents. It highlights advancements in exosomal miRNAs, lncRNAs, circRNAs, and proteins for cancer detection and prognosis. The study also examines engineering strategies for exosome‐based drug delivery systems, their potential to ...
Mohit J. Mehta +7 more
wiley +1 more source
Cholesterol Enrichment of Human Monocyte/Macrophages Induces Surface Exposure of Phosphatidylserine and the Release of Biologically-Active Tissue Factor–Positive Microvesicles [PDF]
, 2006 Ming‐Lin Liu +4 more
openalex +1 more source
Nanoplasmonic Sensing of Heterogeneous Extracellular Vesicles: From Bulk to Single Vesicles
Small Methods, EarlyView.Extracellular vesicles (EVs) are highly heterogeneous nanoscale blood biomarkers. With their tunable implementations, nanoplasmonic platforms can capture myriad vesicular information via scalable bulk analyses of EV biomarkers or high‐resolution single‐vesicle measurements.
Yan Zhang, Chao Wang, Huilin Shao
wiley +1 more source