Results 51 to 60 of about 52,706 (185)

Microguards and micromessengers of the genome [PDF]

, 2016
The regulation of gene expression is of fundamental importance to maintain organismal function and integrity and requires a multifaceted and highly ordered sequence of events.
A Bobrie, A Gioti, A Leiblich, A Lukasik, A Sharma, A Weiberg, AE Hall, AH Buck, B-C Yoo, C Braicu, C Fricke, D Green, D Haig, D Kim, DJ Sharkey, DM Pegtel, DP Bartel, E Marin-Gonzalez, E Tili, G Arnqvist, GL Hager, H Liu, H Valadi, H Zhou, J Lotvall, J Skog, JA Andres, JM Perkel, JR Chevillet, JS Parent, K Ohshima, K Sun, K Wang, L Corrigan, L Vojtech, LA McGraw, LA McGraw, LK Sirot, M Ghildiyal, M Greaves, M Mittelbrunn, MK Lawniczak, ML Squadrito, NS Barteneva, O Rechavi, P Cayirlioglu, P Kumar, P Xu, PB Medawar, PS Mitchell, S Mathivanan, S Sarker, S Weilner, S Wigby, S Wigby, T Chapman, T Chapman, T Chapman, T Chapman, T Chapman, T Dalmay, T Dalmay, T Kogure, TE Swingler, VN Kim, W Filipowicz, WX Chen, X Chen, Y Lee, Y Ouyang   +69 more
core   +1 more source

Preservation of Extracellular Vesicle Integrity and Cargo Using Spiral Microfluidic Chip‐Based Separation

Advanced Materials Technologies, EarlyView.
A spiral microfluidic chip is compared with ultrafiltration for the separation of extracellular vesicles (EVs). The method preserves miRNA cargo and membrane integrity more effectively, resulting in intact vesicle morphology and consistent surface biomarker expression.
Huiseop Lee, Sehyeon Kim, Dasom Kong, Hye‐min Park, Hyun‐Ji Park, Jinsik Kim   +5 more
wiley   +1 more source

Supernatants derived from chemotherapy-treated cancer cell lines can modify angiogenesis [PDF]

, 2012
BACKGROUND: There is evidence that tumours produce substances such as cytokines and microvesicular bodies bearing bioactive molecules, which support the carcinogenic process.
Bodman-Smith, M, Chanthirakumar, C, Coulton, G, Dalgleish, AG, Dennis, JL, Fowler, DW, Gravett, AM, Kaminska, E, Liu, WM   +8 more
core   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Microvesicles from Lactobacillus reuteri (DSM-17938) completely reproduce modulation of gut motility by bacteria in mice.

PLoS ONE, 2020
Microvesicles are small lipid, bilayer structures (20-400 nm in diameter) secreted by bacteria, fungi, archaea and parasites involved in inter-bacterial communication and host-pathogen interactions. Lactobacillus reuteri DSM-17938 (DSM) has been shown to
Christine L West, Andrew M Stanisz, Yu-Kang Mao, Kevin Champagne-Jorgensen, John Bienenstock, Wolfgang A Kunze   +5 more
doaj   +1 more source

Whole-body heat stress and exercise stimulate the appearance of platelet microvesicles in plasma with limited influence of vascular shear stress [PDF]

, 2017
Intense, large muscle mass exercise increases circulating microvesicles, but our understanding of microvesicle dynamics and mechanisms inducing their release remains limited.
Chiesa, Scott T., González-Alonso, José, Kalsi, Kameljit K., Rakobowchuk, Mark, Trangmar, Steven J., Wilhelm, Eurico N.   +5 more
core   +5 more sources

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

Platelets and platelet-derived microvesicles: Phenotype, content, impact on endothelial cells

Медицинская иммунология
Blood platelets are circulating anuclear structures derived from megakaryocytes. Intercellular adhesion molecules, Toll-like receptors, chemokine and cytokine receptors are represented on their surface.
O. I. Stepanova, M. A. Pereviazkina, K. L. Markova, S. A. Selkov, D. I. Sokolov   +4 more
doaj   +1 more source

Announcing , the Official Journal of the American Society for Exosomes and Microvesicles

Journal of Circulating Biomarkers, 2013
This editorial article introduces the new scientific journal Exosomes and Microvesicles (EXMV) , the official journal of the American Society for Exosomes and Microvesicles (ASEMV), and describes its editorial line and mission in relation to the role of ...
Stephen J. Gould, Douglas Taylor, Antonio Chiesi, Winston P. Kuo   +3 more
doaj   +1 more source

Cancer-Associated Thrombosis in Cirrhotic Patients with Hepatocellular Carcinoma. [PDF]

, 2018
It is common knowledge that cancer patients are more prone to develop venous thromboembolic complications (VTE). It is therefore not surprising that patients with hepatocellular carcinoma (HCC) present with a significant risk of VTE, with the portal vein
Burra, P, Campello, E, Russo, Fp., Simioni, P, Spiezia, L, Zanetto, A   +5 more
core   +1 more source