Results 111 to 120 of about 151,098 (403)

Midazolam in Paediatric Anaesthesia [PDF]

Anaesthesia and Intensive Care, 1982
Midazolam was given intravenously to 100 children over the age of 8 years to induce anaesthesia and a similar control group was anaesthetised with diazepam. The actions of midazolam in children were found to be similar to those of diazepam. Midazolam acted more quickly in children than has been reported in adults.
openaire   +3 more sources

Assessment of Pharmacokinetic Drug Interaction of Asciminib with Atorvastatin in Healthy Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Asciminib is the first BCR::ABL1 inhibitor that Specifically Targets the ABL Myristoyl Pocket (STAMP) in patients with chronic myeloid leukemia. This phase 1, two‐treatment‐period, drug‐drug interaction study evaluated the effect of steady‐state asciminib on the pharmacokinetics of atorvastatin.
Matthias Hoch, Wendy Weis, Felix Huth, Seshulatha Jamalapuram, Michelle Quinlan, Amarnath Bandaru, Suleyman Eralp Bellibas, Asmae Mirkou, Shruti Kapoor, Shefali Kakar   +9 more
wiley   +1 more source

Anesthetic drug midazolam inhibits cardiac human ether-à-go-go-related gene channels: mode of action

Drug Design, Development and Therapy, 2015
Nadine Vonderlin,1 Fathima Fischer,1 Edgar Zitron,1,2 Claudia Seyler,1 Daniel Scherer,1 Dierk Thomas,1,2 Hugo A Katus,1,2 Eberhard P Scholz1 1Department of Internal Medicine III, University Hospital Heidelberg, 2German Centre for Cardiovascular ...
Vonderlin N, Fischer F, Zitron E, Seyler C, Scherer D, Thomas D, Katus HA, Scholz EP,   +7 more
doaj  

Propofol versus Midazolam for Upper Gastrointestinal Endoscopy in Cirrhotic Patients: A Meta-Analysis of Randomized Controlled Trials

PLoS ONE, 2015
Background Sedation during gastrointestinal endoscopy is often achieved using propofol or midazolam in general population. However, impaired protein synthesis, altered drug metabolism, and compromised hepatic blood flow in patients with liver cirrhosis ...
H. Tsai, Yu-Cih Lin, Ching-Lung Ko, Horng‐Yuan Lou, Ta-Liang Chen, K. Tam, Chien-Yu Chen   +6 more
semanticscholar   +1 more source

Advancing Predictions of Oral Drug Absorption, CYP3A4 Induction, and Transporter‐Mediated Interactions Using a Human Primary Intestinal 3D Model (EpiIntestinal™)

Clinical Pharmacology &Therapeutics, EarlyView.
Accurate prediction of oral drug absorption in humans is essential for early drug development; however, physiologically relevant human models are lacking. This study aims to comprehensively assess the EpiIntestinal™, a human primary intestinal 3D model, for its ability to predict oral absorption (Fa), intestinal availability (Fg), CYP3A4 induction, and
Paresh P. Chothe, Andrea Whitcher‐Johnstone, Aniruddha Karve, Diane Ramsden, Niresh Hariparsad   +4 more
wiley   +1 more source

Rare as Hens\u27 Teeth: The New Geography of the American Death Penalty [PDF]

, 2016
Today, only a few dozen scattered counties actually impose death sentences, supporting the death penalty’s ...
Garrett, Brandon L.
core   +1 more source

Evolving Real‐World Data and Evidence Use for New Drugs and Regenerative Medical Products Approvals in Japan—An Analysis of the 6‐Year Trend

Clinical Pharmacology &Therapeutics, EarlyView.
Several regulatory initiatives have been made to clarify the acceptability and requirements of real‐world data and real‐world evidence (RWD/E) for the benefit/risk assessment of new medical products in Japan. The objectives of this review were to characterize the use of RWD/E in regulatory applications of new medical products and to describe the ...
Suguru Okami, Kako Shimotsumagari, Yasunari Sadatsuki   +2 more
wiley   +1 more source

Intravenous conscious sedation in patients under 16 years of age. Fact or fiction? [PDF]

, 2003
Recently published guidelines on the use of conscious sedation in dentistry have published varying recommendations on the lower age limit for the use of intravenous conscious sedation.
J A Leitch, JG Meechan, M -T Hosey, N D Robb   +3 more
core   +1 more source

Semiphysiologically based pharmacokinetic model for midazolam and CYP3A mediated metabolite 1‐OH‐midazolam in morbidly obese and weight loss surgery patients

CPT: Pharmacometrics & Systems Pharmacology, 2015
This study aimed to describe the pharmacokinetics of midazolam and its cytochrome P450 3A (CYP3A) mediated metabolite 1‐OH‐midazolam in morbidly obese patients receiving oral and i.v.
M. Brill, Paj Välitalo, A. Darwich, B. van Ramshorst, H. V. Van Dongen, A. Rostami-Hodjegan, M. Danhof, C. Knibbe   +7 more
semanticscholar   +1 more source

Initial Population Sampling Influence on Multi‐Objective Optimization Based on Differential Evolution and Bayesian Inference

International Journal of Circuit Theory and Applications, EarlyView.
This study focused on reducing the simulation counts required for circuit sizing by optimizing the initial population selection in evolutionary algorithms. We investigated the impact of different sampling methods on the efficiency of multi‐objective optimization based on differential evolution and Bayesian inference, a leading algorithm in circuit ...
Georgian Nicolae, Catalin Visan, Dan Curavale, Mihai Boldeanu, Horia Cucu, Andi Buzo   +5 more
wiley   +1 more source