Results 111 to 120 of about 136,839 (238)

Semiphysiologically based pharmacokinetic model for midazolam and CYP3A mediated metabolite 1‐OH‐midazolam in morbidly obese and weight loss surgery patients

CPT: Pharmacometrics & Systems Pharmacology, 2015
This study aimed to describe the pharmacokinetics of midazolam and its cytochrome P450 3A (CYP3A) mediated metabolite 1‐OH‐midazolam in morbidly obese patients receiving oral and i.v.
M. Brill, Paj Välitalo, A. Darwich, B. van Ramshorst, H. V. Van Dongen, A. Rostami-Hodjegan, M. Danhof, C. Knibbe   +7 more
semanticscholar   +1 more source

Comparison of Oral Midazolam and Promethazine with Oral Midazolam alone for Sedating Children during Computed Tomography

Archives of Academic Emergency Medicine, 2018
Introduction: Both midazolam and promethazine are recommended to be used as sedatives in many studies but each have some side effects that limits their use. Combination therapy as an alternative method, may decreases these limitations.
Hassan Barzegari, Behzad Zohrevandi, Kambiz Masoumi, Arash Forouzan, Ali Asgari Darian, Shaqayeq Khosravi   +5 more
doaj   +1 more source

Anesthetic drug midazolam inhibits cardiac human ether-à-go-go-related gene channels: mode of action

Drug Design, Development and Therapy, 2015
Nadine Vonderlin,1 Fathima Fischer,1 Edgar Zitron,1,2 Claudia Seyler,1 Daniel Scherer,1 Dierk Thomas,1,2 Hugo A Katus,1,2 Eberhard P Scholz1 1Department of Internal Medicine III, University Hospital Heidelberg, 2German Centre for Cardiovascular ...
Vonderlin N, Fischer F, Zitron E, Seyler C, Scherer D, Thomas D, Katus HA, Scholz EP,   +7 more
doaj  

Fertilization and Mouse Embryo Development in the Presence of Midazolam [PDF]

, 1991
The development of mouse embryos in vitro has provided a unique opportunity for the study of cellular differentiation and the influence of various agents on differentiation.
Leavitt, Maria
core   +2 more sources

Antiseizure Activity of Midazolam in Mice Lacking δ-Subunit Extrasynaptic GABAA Receptors

Journal of Pharmacology and Experimental Therapeutics, 2015
Midazolam is a benzodiazepine anticonvulsant with rapid onset and short duration of action. Midazolam is the current drug of choice for acute seizures and status epilepticus, including those caused by organophosphate nerve agents.
S. Reddy, Iyan Younus, B. Clossen, D. Reddy   +3 more
semanticscholar   +1 more source

Midazolam por via oral como medicação pré-anestésica em crianças e adolescentes com paralisia cerebral: estudo comparativo das variações do índice bispectral Midazolam por vía oral como medicación preanestésica en niños y adolescentes con parálisis cerebral: estudio comparativo de las variaciones del índice bispectral Oral midazolam as pre-anesthetic medication in children and teenagers with cerebral palsy: a comparative study on the variations of the bispectral index

Revista Brasileira de Anestesiologia, 2009
JUSTIFICATIVA E OBJETIVOS: O midazolam é um derivado benzodiazepínico com ação hipnótica e muito utilizado como medicação pré-anestésica em anestesia pediátrica.
Verônica Vieira da Costa, Rafael Villela Silva Derré Torres, Érika Carvalho Pires Arci, Renato Ângelo Saraiva   +3 more
doaj   +1 more source

Impaired hepatic drug and steroid metabolism in congenital adrenal hyperplasia due to P450 oxidoreductase deficiency [PDF]

, 2010
Objective: Patients with congenital adrenal hyperplasia due to P450 oxidoreductase (POR) deficiency(ORD) present with disordered sex development and glucocorticoid deficiency.
Arlt, Bebia, Chang, de Morais, Dominique Maiter, Dorota Tomalik-Scharte, Fl  ck, Fuhr, Gomes, Hannah E Ivison, Henderson, Jetter, Julia Kirchheiner, Kelley, Kirchheiner, Kranendonk, Nebert, Nicolo, Parkinson, Porter, Ribes, Sachse, Tantcheva-Po  r, Tomalik-Scharte, Uwe Fuhr, Wiebke Arlt   +25 more
core   +2 more sources

Treatment of agitation in terminally ill patients with intranasal midazolam versus subcutaneous midazolam: study protocol for a randomised controlled open-label monocentric trial (MinTU Study)

BMC Palliative Care
Background Intranasal (i.n.) drug application is a widely known and low-invasive route of administration that may be able to achieve rapid symptom control in terminally ill patients. According to the German S3 guideline “Palliative care for patients with
Hanna Hirschinger, Evelyn Jaeger, Stefanie Nittka, Svetlana Hetjens, Christine Lorenz, Constanze Remi, Susanne Saussele, Wolf-K. Hofmann, Deniz Gencer, Tobias Boch   +9 more
doaj   +1 more source

An evaluation of the effectiveness and safety of midazolam in children undergoing dental surgery

Medicina, 2015
Objective: The aim of this study was to evaluate the effectiveness and safety of oral midazolam in children undergoing dental surgery. Materials and methods: A prospective, randomized, controlled trial was conducted to assess the effectiveness and safety
Lina Kalibatienė, Vytenis Kalibatas, Andrius Macas, Darius Trepenaitis   +3 more
doaj   +1 more source

The Antinociceptive Effects of Midazolam on Three Different Types of Nociception in Mice

Journal of Pharmacological Sciences, 2009
Antinociceptive effects of systemically administered midazolam remain controversial. The present study was performed to investigate its antinociceptive effects on different types of nociception in mice. Four different doses of midazolam (1, 3, 10, and 30
Shunsuke Chiba, Tomoki Nishiyama, Masanobu Yoshikawa, Yoshitsugu Yamada   +3 more
doaj