Results 11 to 20 of about 212,558 (382)

Increased Macrophages and C1qA, C3, C4 Transcripts in the Midbrain of People With Schizophrenia

Frontiers in Immunology, 2020
Increased cytokine and inflammatory-related transcripts are found in the ventral midbrain, a dopamine neuron-rich region associated with schizophrenia symptoms.
Tertia D. Purves-Tyson, Tertia D. Purves-Tyson, Kate Robinson, Amelia M. Brown, Danny Boerrigter, Helen Q. Cai, Helen Q. Cai, Christin Weissleder, Samantha J. Owens, Debora A. Rothmond, Cynthia Shannon Weickert, Cynthia Shannon Weickert, Cynthia Shannon Weickert   +12 more
doaj   +3 more sources

A fully automated high-throughput workflow for 3D-based chemical screening in human midbrain organoids

eLife, 2020
Three-dimensional (3D) culture systems have fueled hopes to bring about the next generation of more physiologically relevant high-throughput screens (HTS).
Henrik Renner, Martha Grabos, Katharina J Becker, Theresa E Kagermeier, Jie Wu, Mandy Otto, Stefan Peischard, Dagmar Zeuschner, Yaroslav TsyTsyura, Paul Disse, Jürgen Klingauf, Sebastian A Leidel, Guiscard Seebohm, Hans R Schöler, Jan M Bruder   +14 more
doaj   +2 more sources

Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells

Stem Cell Reports, 2017
Research on human brain development and neurological diseases is limited by the lack of advanced experimental in vitro models that truly recapitulate the complexity of the human brain. Here, we describe a robust human brain organoid system that is highly
Anna S. Monzel, Lisa M. Smits, Kathrin Hemmer, Siham Hachi, Edinson Lucumi Moreno, Thea van Wuellen, Javier Jarazo, Jonas Walter, Inga Brüggemann, Ibrahim Boussaad, Emanuel Berger, Ronan M.T. Fleming, Silvia Bolognin, Jens C. Schwamborn   +13 more
doaj   +2 more sources

Gray-matter volume, midbrain dopamine D2/D3 receptors and drug craving in methamphetamine users. [PDF]

Molecular Psychiatry, 2015
Dysfunction of the mesocorticolimbic system has a critical role in clinical features of addiction. Despite evidence suggesting that midbrain dopamine receptors influence amphetamine-induced dopamine release and that dopamine is involved in ...
Dean, AC, Kohno, M, London, ED, Mandelkern, MA, Morales, AM, Robertson, CL   +5 more
core   +5 more sources

Changes in neural progenitor lineage composition during astrocytic differentiation of human iPSCs [PDF]

eLife
The regional specificity of stem cell-derived astrocytes is believed to be an important prerequisite for their application in disease modelling and cell-based therapies.
Zongze Li, Lucia Fernandez Cardo, Michal Rokicki, Jimena Monzón-Sandoval, Viola Volpato, Frank Wessely, Caleb Webber, Meng Li   +7 more
doaj   +2 more sources

In vitro modeling of the human dopaminergic system using spatially arranged ventral midbrain–striatum–cortex assembloids

Nature Methods, 2023
Ventral midbrain dopaminergic neurons project to the striatum as well as the cortex and are involved in movement control and reward-related cognition.
Daniel Reumann, Christian Krauditsch, Maria Novatchkova, Edoardo Sozzi, Sakurako Nagumo Wong, Michael Zabolocki, Marthe Priouret, Balint Doleschall, Kaja I Ritzau-Reid, Marielle Piber, Ilaria Morassut, Charles Fieseler, A. Fiorenzano, Molly M. Stevens, Manuel Zimmer, Cedric Bardy, Malin Parmar, Jurgen Knoblich   +17 more
semanticscholar   +1 more source

The effects of an 8-week mindful eating intervention on anticipatory reward responses in striatum and midbrain

Frontiers in Nutrition, 2023
IntroductionAccumulating evidence suggests that increased neural responses during the anticipation of high-calorie food play an important role in the tendency to overeat. A promising method for counteracting enhanced food anticipation in overeating might
Lieneke K. Janssen, Lieneke K. Janssen, Iris Duif, Anne E. M. Speckens, Ilke van Loon, Joost Wegman, Jeanne H. M. de Vries, Roshan Cools, Roshan Cools, Esther Aarts   +9 more
doaj   +1 more source

Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality

bioRxiv, 2022
The human brain is a complex, three-dimensional structure. To better recapitulate brain complexity, recent efforts have focused on the development of human specific midbrain organoids.
Sònia Sabaté-Soler, Sarah L Nickels, Cláudia Saraiva, E. Berger, Ugne Dubonyte, Kyriaki Barmpa, Y. Lan, Tsukasa Kouno, J. Jarazo, Graham Robertson, J. Sharif, H. Koseki, Christian Thome, Jay W. Shin, S. Cowley, J. Schwamborn   +15 more
semanticscholar   +1 more source

Responses to dichotic tone-in-noise stimuli in the inferior colliculus

Frontiers in Neuroscience, 2022
Human listeners are more sensitive to tones embedded in diotic noise when the tones are out-of-phase at the two ears (N0Sπ) than when they are in-phase (N0S0).
Langchen Fan, Kenneth S. Henry, Kenneth S. Henry, Kenneth S. Henry, Laurel H. Carney, Laurel H. Carney   +5 more
doaj   +1 more source

Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state

Brain : a journal of neurology, 2021
Idiopathic Parkinson’s disease is characterized by a progressive loss of dopaminergic neurons, but the exact disease aetiology remains largely unknown.
Semra Smajić, C. Prada-Medina, Z. Landoulsi, Jenny Ghelfi, Sylvie Delcambre, C. Dietrich, J. Jarazo, J. Henck, S. Balachandran, S. Pachchek, C. Morris, Paul M. A. Antony, B. Timmermann, S. Sauer, Sandro L. Pereira, J. Schwamborn, P. May, A. Grünewald, M. Spielmann   +18 more
semanticscholar   +1 more source