Results 31 to 40 of about 182,279 (337)

Palmitate and Stearate are Increased in the Plasma in a 6-OHDA Model of Parkinson’s Disease

Metabolites, 2019
Introduction: Parkinson’s disease (PD) is the second most common neurodegenerative disorder, without any widely available curative therapy. Metabolomics is a powerful tool which can be used to identify unexpected pathway-related disease progression
Anuri Shah, Pei Han, Mung-Yee Wong, Raymond Chuen-Chung Chang, Cristina Legido-Quigley   +4 more
doaj   +1 more source

Positive autoregulation of GDNF levels in the ventral tegmental area mediates long-lasting inhibition of excessive alcohol consumption. [PDF]

, 2011
Glial cell line-derived neurotrophic factor (GDNF) is an essential growth factor for the survival and maintenance of the midbrain dopaminergic (DA-ergic) neurons.
Ahmadiantehrani, S, Barak, S, Kharazia, V, Ron, D   +3 more
core   +3 more sources

Sequential Role of SOXB2 Factors in GABAergic Neuron Specification of the Dorsal Midbrain

Frontiers in Molecular Neuroscience, 2018
Studies proposed a model for embryonic neurogenesis where the expression levels of the SOXB2 and SOXB1 factors regulate the differentiation status of the neural stem cells. However, the precise role of the SOXB2 genes remains controversial.
Neoklis Makrides, Elena Panayiotou, Pavlos Fanis, Christos Karaiskos, George Lapathitis, Stavros Malas   +5 more
doaj   +1 more source

Wnt1 Lineage Specific Deletion of Gpr161 Results in Embryonic Midbrain Malformation and Failure of Craniofacial Skeletal Development

Frontiers in Genetics, 2021
Sonic hedgehog (Shh) signaling regulates multiple morphogenetic processes during embryonic neurogenesis and craniofacial skeletal development. Gpr161 is a known negative regulator of Shh signaling. Nullizygous Gpr161 mice are embryonic lethal, presenting
Sung-Eun Kim, Karla Robles-Lopez, Karla Robles-Lopez, Xuanye Cao, Kristyn Liu, Pooja J. Chothani, Nikitha Bhavani, Lauren Rahman, Saikat Mukhopadhyay, Bogdan J. Wlodarczyk, Richard H. Finnell, Richard H. Finnell, Richard H. Finnell   +12 more
doaj   +1 more source

The Dopaminergic Midbrain Encodes the Expected Certainty about Desired Outcomes [PDF]

, 2014
Dopamine plays a key role in learning; however, its exact function in decision making and choice remains unclear. Recently, we proposed a generic model based on active (Bayesian) inference wherein dopamine encodes the precision of beliefs about optimal ...
Dolan, Ray, FitzGerald, Thomas H B, Friston, Karl, Mathys, Christoph, Schwartenbeck, Philipp   +4 more
core   +2 more sources

Rabies screen reveals GPe control of cocaine-triggered plasticity. [PDF]

, 2017
Identification of neural circuit changes that contribute to behavioural plasticity has routinely been conducted on candidate circuits that were preselected on the basis of previous results.
AE Stepien, AH Gittis, B Weissbourd, BN Armbruster, Boris D. Heifets, C Hammond, C Lüscher, Christina K. Kim, CM Bäckman, D Lin, EJ Nestler, ES Boyden, F-M Zhou, G Schiavo, H Taniguchi, HH Yin, IR Wickersham, JA Shuen, JS Park, K Miyamichi, K Miyamichi, K Yonehara, Karl Deisseroth, Katherine E. DeLoach, Kevin T. Beier, KF Raab-Graham, KT Beier, L Madisen, L Petreanu, L Ye, LA Gunaydin, LA Schwarz, Lin Wai Hung, Liqun Luo, M Watabe-Uchida, M Xue, MJ Krashes, NR Wall, P Rajasethupathy, Paul Hoerbelt, PE Rothwell, PW Kalivas, RC Pierce, RL Albin, Robert C. Malenka, S Hippenmeyer, S Lammel, S Lammel, SHR Oliet, Sophie Neuner, Timothy J. Mosca, TJ Mosca, TJ Stachniak, TN Lerner, Y Smith   +54 more
core   +2 more sources

Morphometry MRI in the differential diagnosis of parkinsonian syndromes Morfometria por ressonância magnética no diagnóstico diferencial das síndromes parkinsonianas

Arquivos de Neuro-Psiquiatria, 2010
This study evaluates the diagnostic value of morphometric magnetic resonance imaging (MRI) in the differential diagnosis among Parkinson's disease (PD), progressive supranuclear palsy (PSP) and multiple system atrophy (MSA).
Rômulo L Gama, Daniel F.G Távora, Rodrigo C Bomfim, Cruiff E Silva, Veralice M. de Bruin, Pedro F. de Bruin   +5 more
doaj   +1 more source

A fully automated high-throughput workflow for 3D-based chemical screening in human midbrain organoids

eLife, 2020
Three-dimensional (3D) culture systems have fueled hopes to bring about the next generation of more physiologically relevant high-throughput screens (HTS).
Henrik Renner, Martha Grabos, Katharina J Becker, Theresa E Kagermeier, Jie Wu, Mandy Otto, Stefan Peischard, Dagmar Zeuschner, Yaroslav TsyTsyura, Paul Disse, Jürgen Klingauf, Sebastian A Leidel, Guiscard Seebohm, Hans R Schöler, Jan M Bruder   +14 more
doaj   +1 more source

The Search for Invertebrate Consciousness [PDF]

, 2020
There is no agreement on whether any invertebrates are conscious and no agreement on a methodology that could settle the issue. How can the debate move forward?
Birch, Jonathan
core   +3 more sources

IAP-Based Cell Sorting Results in Homogeneous Transplantable Dopaminergic Precursor Cells Derived from Human Pluripotent Stem Cells

Stem Cell Reports, 2017
Human pluripotent stem cell (hPSC)-derived mesencephalic dopaminergic (mesDA) neurons can relieve motor deficits in animal models of Parkinson's disease (PD).
Daniela Lehnen, Serena Barral, Tiago Cardoso, Shane Grealish, Andreas Heuer, Andrej Smiyakin, Agnete Kirkeby, Jutta Kollet, Harold Cremer, Malin Parmar, Andreas Bosio, Sebastian Knöbel   +11 more
doaj   +1 more source