Results 31 to 40 of about 212,558 (382)
Dorsal Raphe Nucleus Down-Regulates Medial Prefrontal Cortex during Experience of Flow
Previous neuroimaging studies have suggested that the experience of flow aligns with a relative increase in activation of the dorsal raphe nucleus, and relative activation decreases of the medial prefrontal cortex and of the amygdala.
Martin Ulrich +2 more
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Background The brainstem has the critical role of regulating cardiac and respiratory function and it also provides motor and sensory function to the face via the cranial nerves. Despite the observation of a brainstem lesion in a radiological examination,
In‐Ho Jung +9 more
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Bi-allelic JAM2 Variants Lead to Early-Onset Recessive Primary Familial Brain Calcification. [PDF]
Primary familial brain calcification (PFBC) is a rare neurodegenerative disorder characterized by a combination of neurological, psychiatric, and cognitive decline associated with calcium deposition on brain imaging. To date, mutations in five genes have
A. Athanasiou-Fragkouli +86 more
core +8 more sources
Aromatic L-amino acid decarboxylase (AADC) deficiency is a rare genetic disorder characterized by deficient synthesis of dopamine and serotonin. It presents in early infancy, and causes severe developmental disability and lifelong motor, behavioral, and ...
T. Pearson +20 more
semanticscholar +1 more source
Dysregulation of Midbrain Dopamine System and the Pathophysiology of Schizophrenia
Dysregulation of the dopamine system is central to many models of the pathophysiology of psychosis in schizophrenia. However, emerging evidence suggests that this dysregulation is driven by the disruption of upstream circuits that provide afferent ...
S. Sonnenschein, F. Gomes, A. Grace
semanticscholar +1 more source
The diffuse midline glioma H3 K27M-mutant was only added recently to the World Health Organization (WHO) Classification of Tumours of the Central Nervous System.
In Kyeom Kim +4 more
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The purpose of this article is to highlight an uncommon combination of supranuclear downward gaze paralysis with bilateral eyelid ptosis in a 53-years-old man with a radiation induced midbrain tumor and to discuss the aspects regarding the centers and ...
Péricles Maranhão-Filho +2 more
doaj +1 more source
Modeling Parkinson’s disease in midbrain-like organoids
Modeling Parkinson’s disease (PD) using advanced experimental in vitro models is a powerful tool to study disease mechanisms and to elucidate unexplored aspects of this neurodegenerative disorder.
Lisa M. Smits +20 more
semanticscholar +1 more source
Recent studies have demonstrated the generation of midbrain‐like organoids (MOs) from human pluripotent stem cells. However, the low efficiency of MO generation and the relatively immature and heterogeneous structures of the MOs hinder the translation of
Tae Hwan Kwak +18 more
semanticscholar +1 more source
Perineuronal Nets and GABAergic cells in the Inferior Colliculus of Guinea Pigs
Perineuronal nets (PNs) are aggregates of extracellular matrix that have been associated with neuronal plasticity, critical periods, fast-spiking cells and protection from oxidative stress.
Nichole L Foster +4 more
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