Results 91 to 100 of about 6,907 (199)

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source

A guide to selecting high-performing antibodies for human Midkine for use in Western blot and immunoprecipitation [version 3; peer review: 2 approved]

F1000Research
Midkine is a secreted protein that acts as a growth factor or cytokine involved in cell survival and inflammatory processes. It accumulates in amyloid plaques, which are hallmarks of Alzheimer’s Disease (AD). The reproducibility of Midkine research would
Peter S. McPherson, Carl Laflamme, Aled M. Edwards, Kathleen Southern, Riham Ayoubi   +4 more
doaj   +1 more source

A caspase-3 'death-switch' in colorectal cancer cells for induced and synchronous tumor apoptosis in vitro and in vivo facilitates the development of minimally invasive cell death biomarkers [PDF]

, 2013
Novel anticancer drugs targeting key apoptosis regulators have been developed and are undergoing clinical trials. Pharmacodynamic biomarkers to define the optimum dose of drug that provokes tumor apoptosis are in demand; acquisition of longitudinal tumor
Brown, G., Brown, Gill, Cawthorne, C., Dawson, M. J., Dive, C., Dive, Caroline, Hodgkinson, C. L., Kadirvel, M., MacFarlane, M., Simpson, K. L., Trapani, F., Walker, M. J., Whetton, A. D., Williams, K. J., Zhou, C.   +14 more
core   +3 more sources

Midkine in Inflammatory and Toxic Conditions

Current Drug Delivery, 2013
Midkine (MK) is a member of midkine family which is composed of MK and pleotrophin (PTN). MK behaves like a cytokine and growth factor, promotes the proliferation, differentiation, survival, adhesion, migration of cells. MK expression usually increases during ischemia, inflammation, tissue repair, neoplastic transformation and in different toxic ...
openaire   +3 more sources

Ventilator‐Induced Lung Injury: Mechanotransduction and Potential Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Mechanical ventilation (MV) is expected to undergo significant transformative advancements by 2050, with the emergence of personalized ventilation systems that promise to revolutionize respiratory care. However, the risk of ventilator‐induced lung injury (VILI) remains a significant concern at this stage and VILI still exists at that time.
He Ren, Ziqi Shang, Alastair G. Stewart, Ying‐xin Qi, Kai Huang   +4 more
wiley   +1 more source

An image cytometric technique is a concise method to detect adenoviruses and host cell proteins and to monitor the infection and cellular responses induced [PDF]

, 2017
BackgroundGenetically modified adenoviruses (Ad) with preferential replications in tumor cells have been examined for a possible clinical applicability as an anti-cancer agent.
Hanazono Michiko, Hiroshima Kenzo, Morinaga Takao, Nguyễn Thảo Thi Thanh, Sekine Ikuo, Shimada Hideaki, Shingyoji Masato, Tada Yuji, Tagawa Masatoshi, Tatsumi Koichiro, Zhong Boya, 関根 郁夫   +11 more
core   +1 more source

Spatial analysis of HPV‐associated cervical intraepithelial neoplastic tissues demonstrate distinct immune signatures associated with cervical cancer progression

The Journal of Pathology, Volume 268, Issue 2, Page 200-214, February 2026.
Abstract Cervical cancer remains the fourth most common cancer affecting women worldwide, and incidences of other HPV‐related cancers continue to rise. For the development of effective prevention strategies in high‐risk patients, we aimed to better understand the roles of inflammatory pathways and the tumour microenvironment as the main driver of ...
Gianna Pavilion, Hani Vu, Zherui Xiong, Thi Viet Trinh Dang, Blake O'Brien, Michael Walsh, Andrew Causer, Janin Chandra, Quan Nguyen, Ian H Frazer   +9 more
wiley   +1 more source

Systemic inflammation, nutritional status and survival in patients with cancer [PDF]

, 2009
Systemic inflammation, nutritional status and survival in patients with ...
Al Murri, Brown, Cho, Crumley, Crumley, Crumley, Fearon, Forrest, Forrest, Gabay, Glen, Gomez, Gridelli, Halazun, Hara, Hilmy, Ishizuka, Jamieson, Karakiewicz, Kerem, Kobayashi, Krzystek-Korpacka, Leitch, Malik, Marsik, McMillan, McMillan, Morley, Ramsey, Read, Sharma, Sharma, Walsh, Yamanaka   +33 more
core   +1 more source

Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives

PROTEOMICS, Volume 26, Issue 2-3, Page 33-80, February 2026.
ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto, Samaneh Ghadami, Kristen Dellinger   +2 more
wiley   +1 more source

Long-Term Estrogen Receptor Beta Agonist Treatment Modifies the Hippocampal Transcriptome in Middle-Aged Ovariectomized Rats. [PDF]

, 2016
Estradiol (E2) robustly activates transcription of a broad array of genes in the hippocampal formation of middle-aged ovariectomized rats via estrogen receptors (ERalpha, ERbeta, and G protein-coupled ER).
Hrabovszky, E., Kallo, I., Liposits, Zsolt, Rodolosse, A., Sarvari, M., Solymosi, N.   +5 more
core   +1 more source