Results 91 to 100 of about 3,058 (153)

Deciphering the Acetabular Labrum's Cellular Atlas: MDK Inhibition as a Novel Therapeutic Method for Developmental Dysplasia of the Hip

Advanced Science, Volume 12, Issue 37, October 6, 2025.
This study explores developmental dysplasia of the hip (DDH) by analyzing acetabular labrum abnormalities using single‐cell and spatial transcriptomics. Aberrant fibrocartilage stem cell proliferation is linked to DDH progression. Targeting the MK signaling pathway with a specific inhibitor effectively alleviates early DDH abnormalities, offering ...
Runze Yang, Huiling Liu, Minghao Ge, Dingyuan Zhang, Tianhao Xu, Lei Zhang, Yanlin Zhu, Shun Li, Jian Li, Xin Ma, Weili Fu   +10 more
wiley   +1 more source

LYVE-1は肝細胞癌の新たな予後指標である [PDF]

博士（医学） 乙第2794号， 著者名：Koichi Kitagawa・Go Nakajima・Hidekazu Kuramochi・Shun‑Ichi Ariizumi・Masakazu Yamamoto，タイトル：Lymphatic vessel endothelial hyaluronan receptor‑1 is a novel prognostic indicator for human hepatocellular carcinoma，掲載誌：Molecular and Clinical ...
北川,　光一
core   +1 more source

Serum Proteomic Profile Based on the TGF‐β Pathway Stratifies Risk of Hepatocellular Carcinoma

Liver International, Volume 45, Issue 10, October 2025.
ABSTRACT Background Hepatocellular carcinoma (HCC) is the third leading cause of cancer‐related deaths, primarily due to late‐stage diagnosis. In this multicenter study, our goal is to identify functional biomarkers that stratify the risk of HCC in patients with cirrhosis (CP) for early diagnosis.
Xiyan Xiang, Kirti Shetty, Herbert Yu, Bibhuti Mishra, Linda L. Wong, Xianghong Jasmine Zhou, Sanjaya K. Satapathy, James M. Crawford, Patricia S. Latham, Steven‐Huy Han, Brandon Mathew, Nabil N. Dagher, Lawrence Lau, Fellanza Cacaj, Anil K. Vegesna, Srinivasan Dasarathy, Aiwu R. He, Hai Huang, Richard L. Amdur, Lopa Mishra   +19 more
wiley   +1 more source

Enhanced antitumor efficacy of fiber‐modified, midkine promoter‐regulated oncolytic adenovirus in human malignant mesothelioma [PDF]

, 2013
Oncolytic virotherapy using adenoviruses has potential for therapeutic benefits in malignant mesothelioma. However, the downregulation of coxsackie virus/adenovirus receptor (CAR) expression is frequently a critical rate-limiting factor that impedes the ...
Hashimoto‐Tamaoki, Tomoko, Kasahara, Noriyuki, Kubo, Shuji, Okamura, Haruki, Okamura, Nobutaka, Tagawa, Masatoshi, Takagi‐Kimura, Misato, Tamamoto, Atsuko, Yamano, Tomoki   +8 more
core   +1 more source

Integrated Single‐Cell RNA‐Seq Reveals Immunosuppressive Mechanisms of Treg Cell Differentiation and Tumor Microenvironment Interactions in Colorectal Cancer

Cancer Medicine, Volume 14, Issue 17, September 2025.
ABSTRACT Background Colorectal cancer (CRC) remains a major challenge in oncology, necessitating the identification of new therapeutic targets. This study aimed to explore the CRC microenvironment and uncover potential targets using single‐cell RNA sequencing (scRNA‐seq).
Dongwei Li, Jingya Liu, Lixian Yu, Xina Luo, Xiaomei Wu, Ronghui Chen   +5 more
wiley   +1 more source

Lipid-associated macrophages for osimertinib resistance and leptomeningeal metastases in NSCLC

Cell Reports
Summary: Leptomeningeal metastases (LMs) remain a devastating complication of non-small cell lung cancer (NSCLC), particularly following osimertinib resistance.
Yang-Si Li, Wen-Pu Lai, Kai Yin, Mei-Mei Zheng, Hai-Yan Tu, Wei-Bang Guo, Liang Li, Shou-Heng Lin, Zhen Wang, Lu Zeng, Ben-Yuan Jiang, Zhi-Hong Chen, Qing Zhou, Xu-Chao Zhang, Jin-Ji Yang, Wen-Zhao Zhong, Xue-Ning Yang, Bin-Chao Wang, Yi Pan, Hua-Jun Chen, Fa-Man Xiao, Hao Sun, Yue-Li Sun, Xiao-Yan Bai, E.-E. Ke, Jia-Xin Lin, Si-Yang Maggie Liu, Yangqiu Li, Oscar Junhong Luo, Yi-Long Wu   +29 more
doaj   +1 more source

Recent Advances in Deciphering Normal and Diseased Aortic Valve Biology Using Transcriptomic Technologies

Journal of Cellular and Molecular Medicine, Volume 29, Issue 17, September 2025.
ABSTRACT Calcific aortic valve disease (CAVD) is a growing global health burden, with no approved pharmacological treatments to date, indicating a substantial therapeutic gap and the need for deeper insight into its underlying mechanisms. Transcriptomic approaches, particularly RNA sequencing (RNAseq) and single‐cell sequencing (scRNAseq), are emerging
Monica Madalina Tucureanu, Ileana Manduteanu   +1 more
wiley   +1 more source

Traumatic Brain Injury Induces Early Barrier Protective Responses in Incisional Skin Wounds Accelerating Cutaneous Wound Healing

Wound Repair and Regeneration, Volume 33, Issue 5, September/October 2025.
ABSTRACT Though Traumatic Brain Injury (TBI) and skin trauma often occur together, it is unresolved whether TBI changes the healing of skin wounds. We here explored whether TBI impacts the sequence of events during skin wound healing. Incisional skin wounds from mice subjected to TBI were assessed employing unbiased transcriptome analysis and ...
Mahyar Aghapour, Florian Olde Heuvel, Albrecht Fröhlich, Adelheid Heinzl, Pallab Maity, Karmveer Singh, Yongfang Wang, Jinnan Cheng, Francesco Roselli, Karin Scharffetter‐Kochanek   +9 more
wiley   +1 more source

Diagnostic accuracy of midkine for hepatocellular carcinoma: A meta‐analysis

Molecular Genetics & Genomic Medicine, 2020
Background There have been many reports on midkine as a promising marker in the diagnosis of hepatocellular carcinoma (HCC). However, the results are inconsistent and even conflicting.
Yu Zhang, Juan Tang, Xiao Zhou, Shao‐Liang Zhu, Le‐Qun Li   +4 more
doaj   +1 more source

Role of noncoding RNA in vascular remodelling [PDF]

, 2016
Purpose of review: Noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) are becoming fundamentally important in the pathophysiology relating to injury-induced vascular remodelling.
Baker, Andrew H., Bradshaw, Angela C., Deng, Lin   +2 more
core   +1 more source