Altered Blood Molecular Markers of Cardiovascular Function in Rats after Intrauterine Hypoxia and Drug Therapy. [PDF]
Curr Issues Mol Biol, 2023 Many children and adults who have suffered prenatal hypoxia at an early age develop many serious diseases. This disease is an actual problem of pediatric cardiology and little studied.
Popazova O +4 more
europepmc +3 more sources
Changes in the Metabolome of Different Tissues in Response to Streptozotocin Diabetes and Mildronate Exposure: A Metabolomic Assessment [PDF]
MetabolitesBackground: Uncontrolled diabetes is characterised by a loss of blood glucose control and increased oxidation of fatty acids to produce ATP. Use of metabolic inhibitors to blunt fatty acid oxidation and restore glucose metabolism is a poorly studied ...
David Hauton +4 more
doaj +2 more sources
Cardioprotective Activity of Pharmacological Agents Affecting NO Production and Bioavailability in the Early Postnatal Period after Intrauterine Hypoxia in Rats. [PDF]
Biomedicines, 2023 Intrauterine hypoxia in newborns leads to a multifaceted array of alterations that exert a detrimental impact on the cardiovascular system. The aim of this research was to assess the cardioprotective effects of modulators of the nitric oxide (NO) system,
Popazova O +5 more
europepmc +3 more sources
Inhibited Carnitine Synthesis Causes Systemic Alteration of Nutrient Metabolism in Zebrafish [PDF]
Frontiers in Physiology, 2018 Impaired mitochondrial fatty acid β-oxidation has been correlated with many metabolic syndromes, and the metabolic characteristics of the mammalian models of mitochondrial dysfunction have also been intensively studied.
Jia-Min Li +10 more
doaj +2 more sources
A fatty acid analogue targeting mitochondria exerts a plasma triacylglycerol lowering effect in rats with impaired carnitine biosynthesis. [PDF]
PLoS ONE, 2018 L-carnitine is important for the catabolism of long-chain fatty acids in the mitochondria. We investigated how the triacylglycerol (TAG)-lowering drug 2-(tridec-12-yn-1-ylthio)acetic acid (1-triple TTA) influenced lipid metabolism in carnitine-depleted ...
Carine Lindquist +5 more
doaj +2 more sources
Mildronate effects on cognitive function in elderly patients with arterial hypertension
Кардиоваскулярная терапия и профилактика, 2012 Aim. To assess the effects of the “interval” (3 months of treatment, followed by treatment-free 3 months) and “persistent” (52 weeks) therapy with Mildronate (500 mg/d) in elderly patients with arterial hypertension (AH) and cognitive dysfunction ...
S. V. Nedogoda +8 more
doaj +3 more sources
Mildronate and its Neuroregulatory Mechanisms : Targeting the Mitochondria, Neuroinflammation, and Protein Expression [PDF]
Medicina, 2013 This review for the first time summarizes the data obtained in the neuropharmacological studies of mildronate, a drug previously known as a cardioprotective agent.
Beitnere, Ulrika +6 more
core +3 more sources
Changes in the respiratory function of the heart and brain mitochondria of animals after chronic alcohol intoxication affected by a new GABA derivative [PDF]
Research Results in Pharmacology, 2021 Introduction: Chronic ethanol consumption leads to significant functional and structural changes in the mitochondria of the heart and brain, increasing generation of reactive oxygen species.
Tamara A. Popova +9 more
doaj +6 more sources
Кардиоваскулярная терапия и профилактика, 2014 Aim. To assess the effectiveness of Mildronate in the prevention of arrhythmias during the perioperative period of open cholecystectomy under intravenous multicomponent anesthesia.Material and methods.
V. P. Mikhin +3 more
doaj +2 more sources
Fatty acid oxidation is critical for the tumorigenic potential and chemoresistance of pancreatic cancer stem cells. [PDF]
J Transl MedBackground: We have previously demonstrated the significant reliance of pancreatic Cancer Stem Cells (PaCSCs) on mitochondrial oxidative phosphorylation (OXPHOS), which enables versatile substrate utilization, including fatty acids (FAs).
Mascaraque M +11 more
europepmc +3 more sources