Results 11 to 20 of about 932 (190)
Gastrointestinal Disorders, 2023 L-carnitine plays a critical role in sperm functioning and maintaining male fertility. Mildronate is a widely used drug for treating cardiovascular diseases.
Artem P. Gureev +5 more
doaj +1 more source
TRIMETAZIDINE AND MILDRONATE AS DIRECT ACTION Β2 - ADRENOSENSIBILIZERS (EXPERIMENTAL EVIDENCE)
Российский кардиологический журнал, 2002 Trimetazidine and mildronate as direct action β2 - adrenosensibilizers (experimental evidence).
V. I. Tsirkin +6 more
doaj +1 more source
ANTIOXIDANT EFFECT OF MILDRONATE IN PATIENTS AFTER CORONARY REVASCULARISATION
Российский кардиологический журнал, 2009 The study included 149 patients, aged 41–75 years, with Functional Class II-III stable angina, who underwent coronary artery bypass graft (CABG) surgery or percutaneous coronary intervention (PCI).
I. G. Gordeev +2 more
doaj +1 more source
Use of Meldonium in the Treatment of Patients with Coronary Artery Disease and Concomitant Arterial Hypertension [PDF]
, 2019 Coronary artery disease (CAD) remains one of the leading causes of mortality and disability in Ukraine. Arterial hypertension (AH) is one of the most common diseases and a leading risk factor for coronary artery disease.The aim of the work is to evaluate
Vakaliuk, I. (Ihor) +1 more
core +7 more sources
Gut and obesity/metabolic disease: Focus on microbiota metabolites
MedComm, Volume 3, Issue 3, September 2022., 2022 The beneficial and negative metabolites produced by gut microbiota. The gut microbiota produces all kinds of beneficial or negative metabolites and directly affects the intestinal barrier and gut hormone (GLP‐1 and PYY) release. After entering circulation, those metabolites regulate satiety, insulin release, adipose tissue function, and systemic ...
Ke Lin, Lixin Zhu, Li Yang
wiley +1 more source
NMR in Biomedicine, Volume 34, Issue 4, April 2021., 2021 Glucose metabolism is decreased in the diabetic heart. Meldonium may provide a route to counteract this by reducing L‐carnitine levels and decreasing the uptake of fatty acids into the mitochondria, resulting in improved cardiac glucose utilization. Hyperpolarized magnetic resonance has revealed that meldonium treatment elevated pyruvate dehydrogenase ...
Dragana Savic +7 more
wiley +1 more source
Mildronate: An Antiischemic Drug for Neurological Indications [PDF]
CNS Drug Reviews, 2005 ABSTRACTMildronate (3‐(2,2,2‐trimethylhydrazinium)propionate; MET‐88; meldonium, quaterine) is an antiischemic drug developed at the Latvian Institute of Organic Synthesis. Mildronate was designed to inhibit carnitine biosynthesis in order to prevent accumulation of cytotoxic intermediate products of fatty acid β‐oxidation in ischemic tissues and to ...
Nikolajs, Sjakste +2 more
openaire +2 more sources
Рациональная фармакотерапия в кардиологии, 2015 Aim. To estimate an effect of metabolic corrector mildronate on cardiac hemodynamics and endothelium function in patients with ischemic heart disease (IHD) and heart failure (HF)Material and methods.
I. V. Sergienko +4 more
doaj +3 more sources
Mildronate. Chronic fatigue syndrome
Medical alphabet, 2020 Chronic fatigue syndrome (CFS) is a state of constant, impairing quality of life, fatigue, lasting more than 6 months, inexplicable by any of coexisting patient’s pathological conditions. The prevalence of CFS in the world is approximately 2 % of the population (120–140 mln inhabitants of Earth). The etiology of CFS is unknown.
A. V. Filippova +3 more
openaire +2 more sources
ChemMedChem, Volume 15, Issue 13, Page 1139-1149, July 3, 2020., 2020 Sights on a new target: A concise synthesis of C‐3‐substituted pyridine‐2,4‐dicarboxylic acid (2,4‐PDCA) derivatives is reported. The derivatives are potent inhibitors of the human 2‐oxoglutarate‐dependent oxygenase aspartate/asparagine‐β‐hydroxylase (AspH), which is a potential medicinal chemistry target for cancer therapy.
Lennart Brewitz +5 more
wiley +1 more source