Journal of Diabetes Research, Volume 2018, Issue 1, 2018., 2018 The prevalence of diabetes is steadily rising, and once it occurs, it can cause multiple complications with a negative impact on the whole organism. Complications of diabetes may be macrovascular: such as stroke and ischemic heart disease as well as peripheral vascular and microvascular diseases—retinopathy, nephropathy, and neuropathy.
Alina Mihaela Leustean +7 more
wiley +1 more source
Oxidative Medicine and Cellular Longevity, Volume 3, Issue 4, Page 266-274, 2010., 2010 In addition to hemorrhagic cystitis, Fanconi Syndrome is a serious clinical side effect during ifosfamide (IFO) therapy. Fanconi syndrome is a generalized dysfunction of the proximal tubule which is characterized by excessive urinary excretion of glucose, phosphate, bicarbonate, amino acids and other solutes excreted by this segment of the nephron ...
Mohamed M. Sayed-Ahmed +2 more
wiley +1 more source
Mildronate, an inhibitor of carnitine biosynthesis, induces an increase in gamma-butyrobetaine contents and cardioprotection in isolated rat heart infarction [PDF]
, 2006 The inhibition of gamma-butyrobetaine (GBB) hydroxylase, a key enzyme in the biosynthesis of carnitine, contributes to lay ground for the cardioprotective mechanism of action of mildronate.
Dambrova, Maija +6 more
core +1 more source
Investigating New Drug Options for Temozolomide Resistant IDH1 Mutant Glioma [PDF]
, 2023 Gliomas, a prevalent form of malignant brain tumors in adults, often exhibit mutations in the isocitrate dehydrogenase 1 (IDH1) gene. Temozolomide (TMZ) is a commonly used chemotherapy drug for treating gliomas; however, the development of drug ...
Sun, Xueyuan
core +1 more source
Elevated vascular γ-butyrobetaine levels attenuate the development of high glucose-induced endothelial dysfunction [PDF]
, 2013 The aim of the present study was to investigate the effects of vascular tissue levels of l-carnitine and its precursor, γ-butyrobetaine (GBB), on the development of endothelial dysfunction induced by 5 μmol/L lysophosphatidylcholine (LPC), 10 mmol/L ...
Agouni +27 more
core +1 more source
MELDONIUM: EFFECTIVE ACTION POINTS
Кардиоваскулярная терапия и профилактика, 2013 The paper is focused on hypoxia and cell ischemia as universal pathogenetic mechanisms of disease development, which can be addressed by both etiotropic and pathogenetic therapy. The latter is represented by the so-called metabolic correctors. At present,
A. L. Vertkin +4 more
doaj +1 more source
Meldonium (Mildronate): Primum nоn nocere
Pharmacological Research, 2016 [No abstract available]
openaire +4 more sources
Structural Properties, Order-Disorder Phenomena and Phase Stability of Orotic Acid Crystal Forms [PDF]
, 2016 Orotic acid (OTA) is reported to exist in the anhydrous (AH), monohydrate (Hy1) and dimethylsulfoxide monosolvate (SDMSO) forms. In this study we investigate the (de)hydration/desolvation behavior, aiming at an understanding of the elusive structural ...
Brittain H. G. +12 more
core +3 more sources
Pharmacological correction of L-NAME-induced oxide deficiency with derivatives of 3-(2,2,2-trimethylhydrazinium) propionate [PDF]
, 2016 This paper deals with the study of correction of L-NAME-induced endothelial dysfunction by means of 3-(2,2,2-trimethylhydrazinium) propionate ...
Bystrova, N. A. +4 more
core +2 more sources
NEW PATHOGENETIC FACTORS OF ATHEROSCLEROSIS DEVELOPMENT AND POTENTIAL THERAPEUTIC APPROACHES
Кардиоваскулярная терапия и профилактика, 2013 It has been demonstrated that one of the factors in the pathogenesis of atherosclerosis, with the subsequent development of myocardial infarction (MI), stroke (S), or sudden death (SD), is trimethylaminoxide (TMAO), the end-product of dietary choline ...
I. Ya. Kalvinsh
doaj +1 more source