Calcium Signaling in the Ventricular Myocardium of the Goto-Kakizaki Type 2 Diabetic Rat [PDF]
, 2018 The association between diabetes mellitus (DM) and high mortality linked to cardiovascular disease (CVD) is a major concern worldwide. Clinical and preclinical studies have demonstrated a variety of diastolic and systolic dysfunctions in patients with ...
Al Kury, L. +7 more
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Macromolecular Bioscience, Volume 25, Issue 9, September 2025.Following optimization of ionizable lipid proportion via cost‐efficient vortex‐mixing method, lipid nanoparticles (LNPs) with a lower ionizable lipid proportion (27.72%), termed LNP5, are fabricated with histidine decapeptide (His10) during formulation via microfluidic mixing method. His10‐incorporated LNP5 (LNP5H) exhibited a 1.6‐fold increase in gene
Yeonho Bae +4 more
wiley +1 more source
, 2015 Latvijas Zinātņu akadēmijas akadēmiķe profesore Vija Zaiga Kluša : biobibliogrāfija II / Latvijas Universitātes Akadēmiskā bibliotēka; sast. Dagnija Ivbule; korektore Gita Bērziņa; maketu veidojusi Baiba Lazdiņa.
Ivbule, Dagnija +1 more
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Mildronate's protective effects in the peripheral nervous system : Stavudine-induced neuropathy and formalin-induced inflammation [PDF]
, 2010 Funding Information: This work was supported by the Latvian Council of Science Grant Nr. 05-1418; ESF Grant ESS2004/3; Contract No. 453, between the Latvian Institute of Organic Synthesis and the Joint Stock Company “Grindex”; Contract No.
Isajevs, Sergejs +7 more
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ChemMedChem, Volume 19, Issue 24, December 16, 2024.Inhibitors of the 2‐oxoglutarate (2OG)‐dependent hypoxia‐inducible factor prolyl hydroxylases (PHDs) are used for anemia treatment. Structures of the clinical PHD inhibitors Desidustat and Enarodustat complexed with the 2OG oxygenase factor inhibiting hypoxia‐inducible factor‐α (FIH) provide a basis to guide future PHD/2OG oxygenase inhibitor ...
Thomas P. Corner +9 more
wiley +1 more source
The Regulation of Energy Metabolism Pathways Through L-Carnitine Homeostasis [PDF]
, 2011 Non
Edgars Liepinsh +2 more
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Mildronate effectiveness in post-hospital rehabilitation of patients with myocardial infarction
Кардиоваскулярная терапия и профилактика, 2012 Aim. To study the effects of mildronate, as a component of complex therapy, on left ventricular (LV) systolic and diastolic function and exercise capacity (EC) in myocardial infarction (MI) patients undergoing post-hospital rehabilitation.
V. P. Mikhin, O. N. Koltsova
doaj +1 more source
Мелдониум и нейропротекция. Теория, эксперимент и клиническая практика [PDF]
, 2018 У цьому огляді розглянуті можливості корекції метаболізму при гострій ішемії мозку (ГІМ) шляхом активації стрес-лімітуючих систем при застосуванні вірогідного полімодального метаболічного коректора мелдоніуму.
Муслин, В.П. +1 more
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Inhibition of L-carnitine biosynthesis and transport by methyl-γ-butyrobetaine decreases fatty acid oxidation and protects against myocardial infarction [PDF]
, 2015 Publisher Copyright: © 2014 The British Pharmacological Society.Background and Purpose The important pathological consequences of ischaemic heart disease arise from the detrimental effects of the accumulation of long-chain acylcarnitines in the case of ...
Abdul-Ghani +43 more
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Pharmacological correction of the sequelae of acute alcohol-induced myocardial damage with new derivatives of neuroactive amino acids coupled with the blockade of the neuronal NO synthase isoform [PDF]
, 2022 Introduction: Acute alcohol intoxication (AAI) induces a number of myocardial disorders, which result in mitochondrial dysfunction in cardiomyocytes, oxidative stress, and decreased cardiac contractility.
Aida S. Kucheryavenko +7 more
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