Results 111 to 120 of about 45,700 (265)

Soluble urokinase plasminogen activator receptor and outcomes in HFpEF: A TOPCAT ancillary study

ESC Heart Failure, EarlyView.
Abstract Aims Inflammation is postulated to be a key pathogenic mechanism in heart failure with preserved ejection fraction (HFpEF). Soluble urokinase plasminogen activator receptor (suPAR), a regulator of innate immune activity, is associated with incident heart failure; however, its role in HFpEF remains unclear.
Christina G. Hutten, Annika Tekumulla, Anis Ismail, Alexi Vasbinder, Theresa Farhat, Pennelope Kunkle, Sascha N. Goonewardena, Ahmed Abdel‐Latif, Bertram Pitt, Salim S. Hayek   +9 more
wiley   +1 more source

A COMPARATIVE ASSESSMENT OF THE EFFECT OF MINERALOCORTICOID RECEPTOR ANTAGONISTS ON CHANGES IN GALECTIN-3 AND MMP-1 FIBROSIS MARKERS IN PATIENTS WITH CHRONIC CARDIAC FAILURE COMBINED WITH TYPE 2 DIABETES MELLITUS WITH MANIFESTATIONS OF MYOCARDIUM DYSSYNCHRONY

Journal of V. N. Karazin Kharkiv National University: Series Medicine, 2016
A comparative assessment of the effect of mineralocorticoid receptor antagonists on changes in galectin 3 and matrix metalloproteinase 1 fibrosis markers has been carried out on 106 examinations (average age (69 + 10.37) years) with type 2 DM and CCF of ...
T. A. Rudenko
doaj  

Evidence for Aldosterone Antagonism in Heart Failure

Cardiac Failure Review
Activation of the renin–angiotensin–aldosterone system is the ultimate pathophysiological hallmark in heart failure. Though aldosterone primarily appears to regulate electrolyte homeostasis by acting on distal nephrons in the kidneys, its effects are far-
Rishi Sethi, Pravesh Vishwakarma, Akshyaya Pradhan   +2 more
doaj   +1 more source

Finerenone in diabetic chronic kidney disease—Real‐world insights including patients with HFpEF or HFmrEF

ESC Heart Failure, EarlyView.
Abstract Purpose Finerenone, a highly selective non‐steroidal mineralocorticoid receptor antagonist, was approved for the treatment of patients with chronic kidney disease (CKD) and type 2 diabetes mellitus (diabetic kidney disease, DKD). Finerenone reduced the composite endpoint of heart failure events and cardiovascular death in patients with heart ...
Kristian Hellenkamp, Sophia Kaebe, Miroslava Valentova, Stephan von Haehling, Fani Delistefani, Katja Gollisch, Dirk Raddatz, Ann‐Kathrin Schäfer, Michael J. Koziolek, Manuel Wallbach   +9 more
wiley   +1 more source

Simultaneous vaccination against influenza and respiratory syncytial virus in high‐risk heart failure patients

ESC Heart Failure, EarlyView.
In a prospective, randomized study of high‐risk HF patients, simultaneous vaccination against influenza and RSV reduced the risk of the primary composite endpoint (hospitalization for HF, all‐cause death, or infection). The main driver of benefit was a lower incidence of infections.
Jan Biegus, Leszek Szenborn, Michał Tkaczyszyn, Robert Zymlinski, Gad Cotter, Michał Zakliczynski, Krzysztof Reczuch, Mateusz Guzik, Szymon Urban, Marta Rosiek‐Biegus, Berenika Jankowiak, Gracjan Iwanek, Marta Wleklik, Marat Fudim, Piotr Ponikowski   +14 more
wiley   +1 more source

Myeloid Mineralocorticoid Receptor Activation Contributes to Progressive Kidney Disease [PDF]

, 2014
Louis Huang, David J. Nikolic‐Paterson, Yingjie Han, Elyce Ozols, Y. Frank, Morag J. Young, Greg H. Tesch   +6 more
openalex   +1 more source

Novel mutation associated with non‐compaction ventricular myocardium: A case report

ESC Heart Failure, EarlyView.
Yan Li, Xi Wang, Saiyong Chen, Chun Wu, Fushi Piao   +4 more
wiley   +1 more source

Dynamics of urinary chloride and sodium and their link to decongestion in acute heart failure and preserved ejection fraction: NACLOCRo‐HF study

ESC Heart Failure, EarlyView.
The study evaluated urinary chloride (uCl) and sodium (uNa) trajectories in 70 elderly patients hospitalized with acute heart failure and preserved ejection fraction (HFpEF). Urine samples were collected at baseline, 24, 48 and 72 h. A multiparametric approach assessed decongestion using the clinical congestion score (CCS), portal vein (PV) pulsatility
Jorge Campos, Pau Llàcer, François Croset, Marina García, Carlos Pérez, Alberto Pérez, Marina Vergara, Paul Cevallos, Martín Fabregate, Cristina Fernández, Raúl Ruiz, Daniel Useros, Miriam Menacho, Miriam Domínguez, Esteban Pérez, Julio Núñez, Luis Manzano   +16 more
wiley   +1 more source

Design and synthesis of aryl sulfonamide-based nonsteroidal mineralocorticoid receptor antagonists

, 2013
Kentaro Futatsugi, David W. Piotrowski, Agustin Casimiro‐Garcia, Shaughn Robinson, M. F. Sammons, Paula M. Loria, Mary Ellen Banker, Donna N. Petersen, Natalia J. Schmidt   +8 more
openalex   +1 more source

Salt and aldosterone do not get along with each other: implication of mineralocorticoid receptors in the profibrotic action of aldosterone [PDF]

, 2011
Decio Armanini, Lorenzo A. Calò, Cristina Fiore   +2 more
openalex   +1 more source