Results 151 to 160 of about 58,361 (283)
Internal Medicine Journal, EarlyView.Abstract Background Chronic kidney disease (CKD) is a significant public health challenge in Australia, affecting ~10% of the adult population and contributing to substantial morbidity and mortality. Diabetes, hypertension, cardiovascular disease and CKD frequently co‐exist; therefore, a multidisciplinary approach is necessary to manage these ...
M. P. Schlaich +7 more
wiley +1 more source
Steroid Receptors and Vertebrate Evolution
, 2019 Considering that life on earth evolved about 3.7 billion years ago, vertebrates are young, appearing in the fossil record during the Cambrian explosion about 542 to 515 million years ago.
Baker, Michael E.
core
Journal of Fish Biology, EarlyView.Abstract In teleost fishes, cortisol is the major corticoid and has both glucocorticoid and mineralocorticoid actions. However, how fish tissues discriminate between these distinct corticosteroid actions is unclear. In mammals, the major factors responsible for intracellular corticosteroid regulation are glucocorticoid receptors (grs) and the ...
Makoto Kusakabe +4 more
wiley +1 more source
Journal of Internal Medicine, EarlyView.Abstract Introduction Hyperkalaemia is a serious complication in patients with chronic kidney disease (CKD) and heart failure (HF), often leading to the discontinuation of renin–angiotensin–aldosterone system inhibitors (RAASi; renin‐angiotensin system inhibitors [RASi] and mineralocorticoid receptor antagonists [MRAs]) despite their cardiorenal ...
Hans Furuland +6 more
wiley +1 more source
Global kidney health: Are we failing the silent pandemic?
Journal of Internal Medicine, EarlyView.Abstract Chronic kidney disease (CKD), although not infectious, has a sharply rising global incidence, alarming rates of death and disability, and the potential to disrupt health systems and economies. Thus, it demands the urgency and global attention of past pandemics.
Taewon Yi +2 more
wiley +1 more source
Journal of Small Animal Practice, EarlyView.This mini‐review describes the pathophysiology of the disrupted hypothalamic–pituitary–adrenal axis in dogs, and probably cats, with the MDR1 (ABCB1) mutation, ABCB1‐1Δ in dogs and ABCB11930‐1931del TC in cats. Clinical consequences in affected animals are discussed and therapeutic interventions to consider are presented.
K. L. Mealey
wiley +1 more source
Pacing and Clinical Electrophysiology, EarlyView.Abstract Background Quadripolar left ventricular (LV) epicardial leads capable of multipoint pacing (MPP) may have an advantage over conventional bipolar leads for delivering cardiac resynchronization therapy (CRT) by stimulating the lateral LV wall from two distinct locations simultaneously.
Nawaz Z. Safdar +12 more
wiley +1 more source
Pacing and Clinical Electrophysiology, EarlyView.ABSTRACT Introduction Preprocedural imaging can improve the success rate of ventricular tachycardia (VT) ablation. Left ventricular wall thickness (LVWT) measured by cardiac computed tomography (CT) can be used to identify infarct regions. We sought to determine whether an association exists between left ventricular wall thickness (LVWT) as obtained ...
Alwin B. P. Noordman +4 more
wiley +1 more source
Analytical Science Advances, Volume 7, Issue 1, June 2026.ABSTRACT Steroids are critical for numerous physiological processes; disruption in their metabolism is associated with numerous endocrine disorders. Steroid quantification is essential to improve the understanding and diagnosis of these pathologies. Historically, urinary steroid profiling has been performed using low‐throughput gas chromatography mass ...
Joshua T. Bain +4 more
wiley +1 more source