Results 21 to 30 of about 1,369,571 (283)

Conformation of the Mineralocorticoid Receptor N-terminal Domain: Evidence for Induced and Stable Structure [PDF]

, 2010
The mineralocorticoid receptor (MR) binds the steroid hormones aldosterone and cortisol and has an important physiological role in the control of salt homeostasis.
Fischer, Katharina, Watt, Carolyn, McEwan, Iain Joseph, Nicholas C. Price, Kelly, S.M., Katharina Fischer, Price, N.C., McEwan, I. J., Watt, K., Fischer, K., Price, Nicholas C., Sharon M. Kelly, Kate Watt, Iain J. McEwan, Kelly, Sharon M.   +14 more
core   +1 more source

3D models of lamprey corticoid receptor complexed with 11-deoxycortisol and deoxycorticosterone [PDF]

, 2011
The serum of Atlantic sea lamprey, a basal vertebrate, contains two corticosteroids, 11-deoxycortisol and deoxycorticosterone. Only 11-deoxycortisol has high affinity [Kd~3 nM] for the corticoid receptor [CR] in lamprey gill cytosol. To investigate the
Paiyuam Asnaashari, Michael E. Baker, Kayla Y. Uh   +2 more
core   +1 more source

Hypertension in mice lacking 11beta-hydroxysteroid dehydrogenase type 2 [PDF]

, 1999
Deficiency of 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) in humans leads to the syndrome of apparent mineralocorticoid excess (SAME), in which cortisol illicitly occupies mineralocorticoid receptors, causing sodium retention, hypokalemia ...
Mullins, A J, Edwards, Christopher R. W., Seckl, Jonathan R., Jonathan R. Seckl, Christopher R.W. Edwards, Stewart Fleming, Kotelevtsev, Yuri, John J. Mullins, Kotelevtsev, Y, Kenyon, C, Seckl, J R, Mullins, John J., Edwards, C R W, Fleming, S, Christopher Kenyon, Kenyon, Christopher, Brown, R W, Yuri Kotelevtsev, Roger W. Brown   +18 more
core   +1 more source

30 YEARS OF THE MINERALOCORTICOID RECEPTOR: The role of the mineralocorticoid receptor in the vasculature [PDF]

Journal of Endocrinology, 2017
Since the mineralocorticoid receptor (MR) was cloned 30 years ago, it has become clear that MR is expressed in extra-renal tissues, including the cardiovascular system, where it is expressed in all cells of the vasculature. Understanding the role of MR in the vasculature has been of particular interest as clinical trials show that MR antagonism ...
Jennifer J, DuPont, Iris Z, Jaffe
openaire   +2 more sources

Beneficial effects of proanthocyanidins in the cardiac alterations induced by aldosterone in rat heart through mineralocorticoid receptor blockade.

PLoS ONE, 2014
Aldosterone administration in rats results in several cardiac alterations. Previous studies have demonstrated that proanthocyanidins, phenolic bioactive compounds, have cardioprotective effects.
Beatriz Martín-Fernández, Natalia de las Heras, María Valero-Muñoz, Sandra Ballesteros, Yi-Zhou Yao, Peter G Stanton, Peter J Fuller, Vicente Lahera   +7 more
doaj   +1 more source

Crystal structure of the mineralocorticoid receptor DNA binding domain in complex with DNA.

PLoS ONE, 2014
The steroid hormone receptors regulate important physiological functions such as reproduction, metabolism, immunity, and electrolyte balance. Mutations within steroid receptors result in endocrine disorders and can often drive cancer formation and ...
William H Hudson, Christine Youn, Eric A Ortlund   +2 more
doaj   +1 more source

PATIENT WITH CHRONIC HEART FAILURE. RATIONAL CHOICE OF THERAPY

Рациональная фармакотерапия в кардиологии, 2017
The theory of chronic hyperactivation of neurohormonal systems, in particular, sympathoadrenal and renin-angiotensin-aldosterone, is the basis of modern concepts of the pathogenesis of heart failure. The medicinal blocking of these two systems has proved
O. M. Drapkina, D. U. Akasheva
doaj   +1 more source

The Role of the Mineralocorticoid Receptor and Mineralocorticoid Receptor–Directed Therapies in Heart Failure

Endocrinology, 2021
Abstract Mineralocorticoid receptor (MR) antagonists (MRA), also referred to as aldosterone blockers, are now well-recognized for their clinical benefit in patients who have heart failure (HF) with reduced ejection fraction (HFrEF).
Morag J Young, Monica Kanki, Nikshay Karthigan, Penny Konstandopoulos   +3 more
openaire   +2 more sources

Aldosterone deficiency and mineralocorticoid receptor antagonism prevent angiotensin II–induced cardiac, renal, and vascular injury [PDF]

, 2012
Angiotensin II causes cardiovascular injury in part by aldosterone-induced mineralocorticoid receptor activation, and it can also activate the mineralocorticoid receptor in the absence of aldosterone in vitro.
Kim, Hyung-Suk, Fogo, Agnes B., Luther, James M., Luo, Pengcheng, Cohen, Samuel E., Wang, Zuofei, Brown, Nancy J.   +6 more
core   +1 more source

Mineralocorticoid Receptor Antagonists in Diabetic Kidney Disease

Pharmaceuticals, 2021
Diabetes mellitus is a global health issue and main cause of chronic kidney disease. Both diseases are also linked through high cardiovascular morbidity and mortality. Diabetic kidney disease (DKD) is present in up to 40% of diabetic patients; therefore,
Nina Vodošek Hojs, Sebastjan Bevc, Robert Ekart, Nejc Piko, Tadej Petreski, Radovan Hojs   +5 more
doaj   +3 more sources