Results 41 to 50 of about 1,369,571 (283)

Meta-regression of mineralocorticoid receptor antagonist use against study period.

, 2014
Meta-regression of mineralocorticoid receptor antagonist use against study period.
Alastair Kiszely (613694), Maaz Shaikh (613687), Bambang Budi Siswanto (521240), Mehdi Ghaziani (613686), Derrick Bennett (17963), Roohi Shrivastava (613698), Du Xin (613699), Henry Krum (303500), Farshad Farzadfar (439490), Mark Woodward (117775), Gregory Roth (613682), Jean-Christophe Lemarie (613683), Rajit Khosla (613695), Thomas Callender (613681), Carolyn S. P. Lam (613688), Devarsetty Praveen (613697), Anushka Patel (109441), Antonio Barretto (613690), Stéphanie Gicquel (613684), Shadi Rahimzadeh (613685), Karen Sliwa (613689), Daniel Herpin (613692), Thomas Eliasz (613693), Stephen MacMahon (141509), Kazem Rahimi (135073), John Atherton (301088), Anna Forbes (275134), Tatjana Petrinic (613696), Alejandro Diaz (613691), John McMurray (135109)   +29 more
core   +1 more source

The effect of spironolactone on cardiac and renal fibrosis following myocardial infarction in established hypertension in the transgenic Cyp1a1Ren2 rat.

PLoS ONE, 2021
AimsThe renin-angiotensin-aldosterone axis plays a key role in mediating cardiac and kidney injury. Mineralocorticoid receptor antagonism has beneficial effects on cardiac dysfunction, but effects are less well quantified in the cardiorenal syndrome ...
C J Leader, G T Wilkins, R J Walker
doaj   +1 more source

SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho Deficiency

Advanced Science, EarlyView.
Klotho deficiency promotes podocyte mitochondrial dysfunction and ferroptosis through activation of the PKCα/CUX1/SPARC/TGFβ‐RII axis. SPARC emerges as a key mediator linking Klotho loss to podocyte injury in DKD and other kidney injury models, suggesting broader implications for CKD progression.
Qing Yang, Huimin Jiang, Chenyang Xiong, Xindi Zhou, Qinqin Tan, Han Xiao, Lan Qiu, Chun Gan, Yaxi Chen, Haiping Yang, Wei Jiang, Qiu Li   +11 more
wiley   +1 more source

Design, synthesis, and evaluation of naphthalidinamide analogues as nonsteroidal mineralocorticoid receptor antagonists

Journal of Chemical Research
Inappropriate overactivation of the mineralocorticoid receptor by the steroid hormones aldosterone or cortisol contributes to the development of cardiovascular diseases.
Mingguang Zhang, Yan Pang, Yurui Zhao, Sibei Chen, Cheng Guo   +4 more
doaj   +1 more source

Expression of genes encoding mineralocorticoid biosynthetic enzymes and the mineralocorticoid receptor, and levels of mineralocorticoids in the bovine follicle and corpus luteum

The Journal of Reproduction and Development, 2019
Unlike sex steroids, mineralocorticoids have attracted limited attention in ovarian physiology. Recent studies on primates have indicated possible local synthesis and action of mineralocorticoids in the ovary.
Memory MUKANGWA, Koki TAKIZAWA, You AOKI, Seizo HAMANO, Masafumi TETSUKA   +4 more
doaj   +1 more source

Antidepressant-like mechanism of honokiol in a rodent model of corticosterone-induced depression [PDF]

Journal of Integrative Neuroscience, 2020
Depression is closely linked to hypothalamus-pituitary-adrenal axis hyperactivity. Honokiol, a biphenolic lignan compound obtained from the traditional Chinese medicine Magnolia officinalis, can reduce the activity of the hypothalamus-pituitary-adrenal ...
Bo Zhang, Yu Li, Miao Liu, Xiao-Hua Duan, Kai-Li Hu, Li-Na Li, Xue Yu, Hong-Sheng Chang
doaj   +1 more source

The mineralocorticoid receptor and its coregulators [PDF]

Journal of Molecular Endocrinology, 2009
The mineralocorticoid receptor (MR) is a member of the nuclear receptor superfamily and is essential for controlling sodium transport in epithelial tissues such as the kidney and colon. Moreover, it is also present in other non-epithelial tissues and is capable of activation by both mineralocorticoids and glucocorticoids.
Jun, Yang, Morag J, Young
openaire   +2 more sources

Downregulation of brain mineralocorticoid and glucocorticoid receptor by antisense oligodeoxynucleotide treatment fails to alter spatial navigation in rats.

, 1998
Adult male Brown Norway rats were long-term intracerebroventricularly (i.c.v.) infused with antisense oligodeoxynucleotides (18-mer, double endcapped phosphorothioate protected) targeting either mineralocorticoid or glucocorticoid receptor mRNA, or ...
Reul, J., Lörscher, P, Landgraf, R, Probst, J C, Rainer Landgraf, Johannes M.H.M. Reul, Conzelmann, C., Probst, J., Holsboer, F, Lörscher, P., Landgraf, R., Joseph C. Probst, Holsboer, F., Mario Engelmann, Charlotte Conzelmann, Florian Holsboer, Engelmann, M., Reul, J M, Patrick Lörscher, Conzelmann, C, Engelmann, M   +20 more
core   +1 more source

Increased Disarray of Extracellular Matrix Collagen‐I Fiber Network and Compromised Biomechanics in Aortae From Marfan‐Syndrome Mice Assessed Through Combined Opto‐Biomechatronics

Advanced Science, EarlyView.
Combined structure‐function assessment in aortic rings from Marfan mice using MechaMorph Opto‐Biomechatronics technology relates increased elasticity (stiffness) and dynamic viscosity and less ordered extracellular matrix 3D‐structure (collagen) as potential causes for impaired Windkessel function and compromised haemodynamics in Marfan's syndrome ...
Dominik Schneidereit, Anika Nagel, Vanessa I. T. Zwaans, Laureen Schurr, Jonas Ahr, Michael Haug, Anna Piluso, Alexandra Sporkova, Matthias Karck, Andreas H. Wagner, Oliver Friedrich   +10 more
wiley   +1 more source

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source