Results 51 to 60 of about 1,369,571 (283)

Mineralocorticoid receptor expression and increased survival following neuronal injury

, 2003
Glucocorticoids, acting via the mineralocorticoid receptor, are required for granule neuronal survival in the rat dentate gyrus. Whether this mineralocorticoid receptor-mediated neuroprotective effect has more general applicability is unknown.
Seckl, Jonathan R, Olsson, Tommy, Lai, Maggie, Wieloch, Tadeusz, Gidö, Gunilla,, Johansson, Inga-Maj, Gidö, Gunilla, Macleod, Malcolm R, Johansson, Inga-Maj,, Söderström, Ingegerd, Söderström, Ingegerd,, Olsson, Tommy,, Lund University., Wieloch, Tadeusz,   +13 more
core   +1 more source

Mineralocorticoid Receptor Antagonists-A New Sprinkle of Salt and Youth

, 2016
Skin atrophy and impaired cutaneous wound healing are the recognized side effects of topical glucocorticoid (GC) therapy. Although GCs have high affinity for the glucocorticoid receptor, they also bind and activate the mineralocorticoid receptor.
Stojadinovic, Olivera, Jozic, Ivan, Lindley, Linsey E, Tomic Canic, Marjana   +3 more
core   +2 more sources

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

AGING MEDICINE, EarlyView.
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley   +1 more source

The role of mineralocorticoid receptor function in treatment-resistant depression

, 2013
BACKGROUND: Treatment-resistant depression patients show both reduced glucocorticoid receptor function and a hyperactive hypothalamic-pituitary-adrenal axis. However, few studies have examined the role of the mineralocorticoid receptor.
Juruena, Mario F, Poon, Lucia, Juruena, Mario; id_orcid, Pariante, Carmine M, Cleare, Anthony J, Pariante, Carmine M.; id_orcid, Papadopoulos, Andrew S, Lightman, Stafford, Papadopoulos, Andrew S., Cleare, Anthony J.; id_orcid   +9 more
core   +1 more source

Hypertension in obesity: A focus on individualized pharmacotherapy and the role of body composition, on behalf of the European Society of Hypertension Working Group on Diabetes and Metabolic Risk Factors and Working Group on Lifestyle, Cardiovascular Pharmacotherapy and Adherence

British Journal of Clinical Pharmacology, EarlyView.
Hypertension in obesity represents a major global health challenge, closely linked to the global epidemics of obesity, type 2 diabetes and metabolic dysfunction. Excess adiposity contributes to elevated blood pressure through multiple, interrelated mechanisms, including activation of the renin–angiotensin–aldosterone system, sympathetic nervous system ...
Christina Antza, Andrej Belancic, Jens Jordan, Alberto Esteban, Anna Oliveras, Ryan McNally, Panagiota Anyfanti, Jorie Versmissen, María S. Fernández‐Alfonso, Vasilios Kotsis, Thomas Weber, Alexandre Persu, Reinhold Kreutz   +12 more
wiley   +1 more source

Mineralocorticoid Receptor Blocker Prevents Mineralocorticoid Receptor–Mediated Inflammation by Modulating Transcriptional Activity of Mineralocorticoid Receptor–p65–Signal Transducer and Activator of Transcription 3 Complex

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Mineralocorticoid receptor (MR) induces cardiac inflammation cooperatively with nuclear factor‐κB and signal transducer and activator of transcription 3 (STAT3); MR blockers exert anti‐inflammatory effects.
Naoto Kuyama, Satoshi Araki, Koichi Kaikita, Nobuhiro Nakanishi, Naoya Nakashima, Shinsuke Hanatani, Yuichiro Arima, Masahiro Yamamoto, Taishi Nakamura, Eiichiro Yamamoto, Kenichi Matsushita, Kunihiko Matsui, Kenichi Tsujita   +12 more
doaj   +1 more source

Mineralocorticoid-receptor signalling in vascular smooth muscle

, 2013
Human data suggest that eplerenone and spironolactone lowers blood pressure by mechanisms independent of the distal tubule. Now, a novel inducible conditional knockout model of the mineralocorticoid receptor (MR) in vascular smooth muscle cells (VSMCs ...
Luft, F.C., Wu, J.
core   +1 more source

How developmental stressors affect mitochondrial respiratory function: a systematic review and meta‐analysis

Biological Reviews, EarlyView.
ABSTRACT The environmental conditions organisms experience during early development can have powerful and sustained effects on morphology, physiology, behaviour, and performance. Such developmental effects can influence reproductive success, survival, and life‐history strategies and can be transmitted across generations (i.e.
Ondi L. Crino, Christopher R. Friesen, Geoffrey E. Hill, Dalton C. Leibold, Pablo Recio, Karine Salin, Kristoffer H. Wild, Daniel W.A. Noble   +7 more
wiley   +1 more source

Eplerenone in the Treatment of Polypoidal Choroidal Vasculopathy

Case Reports in Ophthalmology, 2015
Overactivation of mineralocorticoid receptor pathways has been implicated in the pathophysiology of central serous chorioretinopathy (CSCR). Recently, mineralocorticoid receptor antagonists such as eplerenone have demonstrated success in treating ...
Kapil G. Kapoor, Alan L. Wagner
doaj   +1 more source

Drug Insight: eplerenone, a mineralocorticoid-receptor antagonist

, 2008
Increasing recognition of the role of aldosterone in cardiovascular disease has been supported by a significant body of evidence from animal models. This evidence has been translated into clinical practice, and large-scale, randomized, placebo-controlled
McConnell, John M. C., McInnes, Gordon T, Gordon T McInnes, John MC Connell, Frances McManus, McInnes, Gordon T., Connell, John M C, McManus, Frances   +7 more
core   +1 more source