Results 31 to 40 of about 1,369,571 (283)

Mineralocorticoid receptor blockade during a rat's first violent encounter inhibits its subsequent propensity for violence. [PDF]

, 2013
In individuals naive to serious conflict in an unfamiliar environment, violence has long-lasting effects on subsequent aggressive behavior. This effect of the stressful experience of a first violent conflict occurs in victims as well as offenders.
Meelis, W., Kruk, M. R., Kruk, M.R., Kloet, E. R., Haller, J., Haller, József, Kloet, E.R. de   +6 more
core   +1 more source

Antiapoptotic effects of velvet antler polypeptides on damaged neurons through the hypothalamic-pituitary-adrenal axis [PDF]

Journal of Integrative Neuroscience, 2020
We investigated the effects of velvet antler polypeptide on cognitive impairment and the underlying mechanisms. Hydrogen peroxide-induced cell injury was used to establish an in vitro model of SH-SY5Y cells.
Qing Yang, Jia-Nan Lin, Xin Sui, Hui Li, Mo Kan, Ji-Feng Wang, Jing Li, Zhuang Zhang, Xiao-Ran Liu, Si-Tong Ming, Xiao-Bo Qu, Na Li
doaj   +1 more source

Mineralocorticoid Receptor Antagonists in ESKD [PDF]

Clinical Journal of the American Society of Nephrology, 2020
There is an urgent need for interventions that reduce cardiovascular risks in patients with ESKD. Recently there has been considerable interest in whether blocking the effects of the mineralocorticoid aldosterone could be such an intervention.
Adhish, Agarwal, Alfred K, Cheung
openaire   +2 more sources

A SELECTIVE ANTAGONIST OF MINERALOCORTICOID RECEPTOR EPLERENONE IN CARDIOLOGY PRACTICE [PDF]

, 2015
The role of aldosterone in pathophysiological processes is considered. The effects of the selective antagonist of mineralocorticoid receptor eplerenone are analyzed.
B. B. Gegenava, O. M. Drapkina
core   +1 more source

Mineralocorticoid Receptor Pathway and Its Antagonism in a Model of Diabetic Retinopathy

, 2021
International audienceDiabetic retinopathy remains a major cause of vision loss worldwide. Mineralocorticoid receptor (MR) pathway activation contributes to diabetic nephropathy, but its role in retinopathy is unknown.
Naud, M.C., Lassiaz, P., Herrero Vanrell, María Del Rocío, Levy, Rinath, Bravo-Osuna, Irene, Behar-Cohen, F., Berdugo, M., Naud, Marie-Cristine, Moulin, Alexandre, Zhao, M., Naud, Marie-Christine, Moulin, A., Guegan, Justine, Lassiaz, Patricia, Pussard, E., Levy, R., Azan, Frédéric, Bravo Osuna, Irene, Zhao, Min, Azan, F., Pussard, Eric, Herrero-Vanrell, Rocio, Delaunay, K., Herrero-Vanrell, R., Guegan, J., Bravo-Osuna, I., Gelize, Emmanuelle, Berdugo, Marianne, Behar-Cohen, Francine, Gelize, E., Delaunay, Kimberley, Alexandre Moulin, Frédéric Azan, Patricia Lassiaz, Emmanuelle Gelize, Marianne Berdugo, Min Zhao, Marie-Christine Naud, Francine Behar-Cohen, Kimberley Delaunay, Eric Pussard, Irene Bravo-Osuna, Rinath Levy, Justine Guegan, Rocio Herrero-Vanrell   +44 more
core   +1 more source

The Promiscuous Mineralocorticoid Receptor [PDF]

Hypertension, 2016
See related article, pp 897–905 The article by Briet et al1 in this issue, “Aldosterone-induced vascular remodeling and endothelial dysfunction require functional angiotensin type 1a receptors,” represents a prodigious amount of work by the authors: it is not surprising that the first 3 are credited as having equally contributed. The authors build on
openaire   +2 more sources

Approaches towards tissue‐selective pharmacology of the mineralocorticoid receptor

, 2022
Mineralocorticoid receptor antagonists (MRAs) are highly effective therapies for cardiovascular and renal disease. However, the widespread clinical use of currently available MRAs in cardiorenal medicine is hampered by an increased risk of hyperkalaemia.
De Bosscher, Karolien, Dorien Clarisse, Karolien de Bosscher, Achim Lother, Clarisse, Dorien, Deng, Lisa, Lother, Achim, Lisa Deng   +7 more
core   +1 more source

30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Nongenomic effects via the mineralocorticoid receptor [PDF]

Journal of Endocrinology, 2017
The mineralocorticoid receptor (MR) belongs to the steroid hormone receptor family and classically functions as a ligand-dependent transcription factor. It is involved in water-electrolyte homeostasis and blood pressure regulation but independent from these effects also furthers inflammation, fibrosis, hypertrophy and remodeling in cardiovascular ...
Stefanie, Ruhs, Alexander, Nolze, Ralf, Hübschmann, Claudia, Grossmann   +3 more
openaire   +2 more sources

Mineralocorticoid Receptor Antagonism Prevents the Synergistic Effect of Metabolic Challenge and Chronic Kidney Disease on Renal Fibrosis and Inflammation in Mice

Frontiers in Physiology, 2022
Obesity and/or metabolic diseases are frequently associated with chronic kidney disease and several factors associated with obesity may contribute to proteinuria and extracellular matrix production.
Roberto Palacios-Ramirez, Ixchel Lima-Posada, Benjamin Bonnard, Marie Genty, Amaya Fernandez-Celis, Judith Hartleib-Geschwindner, Fabienne Foufelle, Natalia Lopez-Andres, Krister Bamberg, Frederic Jaisser, Frederic Jaisser   +10 more
doaj   +1 more source

Acute Kidney Injury After Mechanical Thrombectomy for Stroke in Patients With Pre‐Existing Renal Impairment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Acute kidney injury (AKI) is a common but often underrecognized complication in ischemic stroke patients undergoing mechanical thrombectomy, particularly among those with pre‐existing renal impairment. This study evaluated the incidence, risk factors, and clinical impact of AKI in this high‐risk population.
Michał Borończyk, Marcel Pilarek, Emilia Jaworska, Natalia Kardas, Oliwia Barnaś, Julia Woźniak, Iga Machała, Julia Węgrzynek‐Gallina, Joanna Siuda, Anna Hawrot‐Kawecka, Anetta Lasek‐Bal   +10 more
wiley   +1 more source