Results 11 to 20 of about 1,419,720 (263)

Mineralocorticoid receptor antagonists

Current Hypertension Reports, 2007
With an increasingly aging population, the need for effective treatment of cardiovascular diseases (eg, heart failure, hypertension, and ischemic heart disease) cannot be overemphasized.
Parthasarathy, Hari Krishnan, MacDonald, Thomas M.   +1 more
core   +4 more sources

Mineralocorticoid Receptor Antagonists and the Metabolic Syndrome [PDF]

Current Hypertension Reports, 2010
Key components of the metabolic syndrome (MetS), ie, obesity and insulin resistance, are associated with increased aldosterone production and mineralocorticoid receptor (MR) activation.
Adler, Gail K, Tirosh, Amir, Garg, Rajesh, Amir Tirosh, Rajesh Garg, Gail K. Adler   +5 more
core   +3 more sources

Mineralocorticoid receptor antagonists

, 2018
Hypertension, post-myocardial infarction, and heart failure are the cardiovascular clinical syndromes where mineralocorticoid receptor antagonists (MRAs) have shown a beneficial effect.
João Pedro Ferreira, Faiez Zannad
core   +2 more sources

Regulation of Klotho Production by Mineralocorticoid Receptor Signaling in Renal Cell Lines [PDF]

Biomolecules
Through the mineralocorticoid receptor, aldosterone controls extracellular volume and arterial blood pressure by stimulating Na+ absorption and K+ secretion in epithelial cells of the kidney, colon, and several glands.
Elena Kohm, Martina Feger, Michael Föller   +2 more
doaj   +2 more sources

Mineralocorticoid receptor antagonists: new extended roles in cardio- and nephroprotection [PDF]

Медицинский совет, 2018
The article presents the contemporary views of the role of aldosterone in the progression of cardiovascular and renal diseases. It addresses matters related to the efficacy and safety of mineralocorticoid receptor antagonists in patients with chronic ...
A. M. Esayan, A. N. Nimgirova
doaj   +2 more sources

Managing resistant hypertension: focus on mineralocorticoid-receptor antagonists

Vascular Health and Risk Management, 2017
Juan Carlos Yugar-Toledo,1 Rodrigo Modolo,2 Ana Paula de Faria,2 Heitor Moreno2 1São José do Rio Preto Medicine School – FAMERP, São José do Rio Preto, 2School of Medical Sciences, University of Campinas (UNICAMP ...
Yugar-Toledo JC, Modolo R, de Faria AP, Moreno H   +3 more
doaj   +1 more source

Heart failure: the role for mineralocorticoid receptor antagonists

Swiss Medical Weekly, 2014
Mineralocorticoid receptor antagonists (MRA’s) have been shown to be effective in patients with HFREF while their role in patients with HFPEF remains controversial. Despite a class  one indication in both the ESC and AHA/ACC heart failure guidelines
Bertram Pitt
doaj   +3 more sources

Clinical application of mineralocorticoid receptor antagonists in chronic heart failure

Медицинский совет, 2014
The review of literature discusses pathogenetic aspects of chronic heart failure and post-infarction remodelling in the heart. The focus is on the role of neurohormonal activation and the important role of aldosterone.
MG Bubnova
doaj   +2 more sources

The cardioprotective effects of mineralocorticoid receptor antagonists

Pharmacology & Therapeutics, 2014
Item does not contain fulltextDespite state-of-the-art reperfusion therapy, morbidity and mortality remain significant in patients with an acute myocardial infarction.
Deinum, J., Frohlich, G.M., Berg, T.N.A. van den, Hausenloy, D.J., Rongen, G.A.P.J.M., Riksen, N.P.   +5 more
core   +4 more sources

MINERALOCORTICOID RECEPTOR ANTAGONISTS THERAPY IN RESISTANT HYPERTENSION: TIME TO IMPLEMENT NEW GUIDELINES? [PDF]

Frontiers in Cardiovascular Medicine, 2015
Despite the availability of anti-hypertensive medications with increasing efficacy up to 50% of hypertensive patients have blood pressure levels (BP) not at the goals set by international societies.
Giuseppe eMaiolino, Matteo eAzzolini, Gian Paolo eRossi   +2 more
doaj   +2 more sources