Results 21 to 30 of about 16,507 (152)
Consilium Medicum, 2022 Mineralocorticoid receptor antagonists (MRAs) are part of basic medical therapy for heart failure. The clinical efficacy of MRAs has been proven by randomized clinical trials. To review comparative efficacy and tolerability data between the two main MRAs,
Natalia V. Safronova +2 more
doaj +1 more source
Efficacy of Mineralocorticoid Receptor Antagonists on Kidney and Cardiovascular Outcomes in Patients With Chronic Kidney Disease: An Umbrella Review [PDF]
Kidney Medicine+2 more
exaly +2 more sources
Frontiers in Physiology, 2022 Obesity and/or metabolic diseases are frequently associated with chronic kidney disease and several factors associated with obesity may contribute to proteinuria and extracellular matrix production.
Roberto Palacios-Ramirez +10 more
doaj +1 more source
Regulation of Klotho Production by Mineralocorticoid Receptor Signaling in Renal Cell Lines
BiomoleculesThrough the mineralocorticoid receptor, aldosterone controls extracellular volume and arterial blood pressure by stimulating Na+ absorption and K+ secretion in epithelial cells of the kidney, colon, and several glands.
Elena Kohm +2 more
doaj +1 more source
Endocrinology, Diabetes & Metabolism Case Reports, 2021 Primary aldosteronism is one of the most common (affecting up to 10%) yet treatable causes of hypertension in our community, notable due to an associated elevated risk of atrial fibrillation, stroke and myocardial infarction compared to essential ...
Lachlan M Angus, Jun Yang, Ada S Cheung
doaj +1 more source
Network meta-analysis of mineralocorticoid receptor antagonists for diabetic kidney disease
Frontiers in Pharmacology, 2022 Diabetic kidney disease (DKD) is one of the major causes of end-stage renal disease (ESRD). To evaluate the efficacy and safety of different types of mineralocorticoid receptor antagonists (MRAs) in diabetic kidney disease patients, we conducted this ...
Yichuan Wu +13 more
doaj +1 more source
Mineralocorticoid Receptor Activation and Mineralocorticoid Receptor Antagonist Treatment in Cardiac and Renal Diseases [PDF]
Hypertension, 2015 Cardiac and renal diseases remain major challenges for healthcare systems in developed countries and commonly coexist, with a disorder in the heart or kidney often leading to secondary dysfunction or injury in the other organ. Indeed, the term cardiorenal syndrome has been introduced to describe the broad spectrum of disease involving both the heart ...
Johann, Bauersachs +2 more
openaire +2 more sources
Frontiers in Cardiovascular Medicine, 2015 Despite the availability of anti-hypertensive medications with increasing efficacy up to 50% of hypertensive patients have blood pressure levels (BP) not at the goals set by international societies.
Giuseppe eMaiolino +2 more
doaj +1 more source
Eplerenone in the Treatment of Polypoidal Choroidal Vasculopathy
Case Reports in Ophthalmology, 2015 Overactivation of mineralocorticoid receptor pathways has been implicated in the pathophysiology of central serous chorioretinopathy (CSCR). Recently, mineralocorticoid receptor antagonists such as eplerenone have demonstrated success in treating ...
Kapil G. Kapoor, Alan L. Wagner
doaj +1 more source
Kidney Research and Clinical Practice, 2018 Background: Previous studies have shown that aldosterone antagonists have a proteinuria-lowering effect in patients with proteinuria and progressive proteinuric disease not adequately controlled by the use of angiotensin receptor blockers (ARBs ...
Byung Chul Yu +6 more
doaj +1 more source