Results 31 to 40 of about 1,285,117 (188)

Hypertension in mice lacking 11beta-hydroxysteroid dehydrogenase type 2 [PDF]

, 1999
Deficiency of 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) in humans leads to the syndrome of apparent mineralocorticoid excess (SAME), in which cortisol illicitly occupies mineralocorticoid receptors, causing sodium retention, hypokalemia ...
Mullins, A J, Edwards, Christopher R. W., Seckl, Jonathan R., Jonathan R. Seckl, Christopher R.W. Edwards, Stewart Fleming, Kotelevtsev, Yuri, John J. Mullins, Kotelevtsev, Y, Kenyon, C, Seckl, J R, Mullins, John J., Edwards, C R W, Fleming, S, Christopher Kenyon, Kenyon, Christopher, Brown, R W, Yuri Kotelevtsev, Roger W. Brown   +18 more
core   +1 more source

Efficacy and Safety of Mineralocorticoid Receptor Antagonists in Patients with Heart Failure with Preserved Ejection Fraction: A Systematic Review

Efficacy and Safety of Mineralocorticoid Receptor Antagonists in Patients with Heart Failure with Preserved Ejection Fraction: A Systematic ...
Lídia Ana Zytinsky Moura, Ricardo Mourilhe Rocha, Diretrizes SBC, Silvia Marinho Martins, Denilson Campos de Albuquerque, Marcus Vinicius Simões, Fabiana G. Marcondes Braga, Luis Claudio Danzmann, Mucio Tavares de Oliveira-Júnior, José Albuquerque de Figueiredo-Neto   +9 more
core   +9 more sources

Rational drug therapy of chronic heart failure: the role of mineralocorticoid receptor antagonists: review

Consilium Medicum, 2022
Mineralocorticoid receptor antagonists (MRAs) are part of basic medical therapy for heart failure. The clinical efficacy of MRAs has been proven by randomized clinical trials. To review comparative efficacy and tolerability data between the two main MRAs,
Natalia V. Safronova, Igor V. Zhirov, Sergey N. Tereshchenko   +2 more
doaj   +1 more source

Mineralocorticoid Receptor Antagonism Prevents the Synergistic Effect of Metabolic Challenge and Chronic Kidney Disease on Renal Fibrosis and Inflammation in Mice

Frontiers in Physiology, 2022
Obesity and/or metabolic diseases are frequently associated with chronic kidney disease and several factors associated with obesity may contribute to proteinuria and extracellular matrix production.
Roberto Palacios-Ramirez, Ixchel Lima-Posada, Benjamin Bonnard, Marie Genty, Amaya Fernandez-Celis, Judith Hartleib-Geschwindner, Fabienne Foufelle, Natalia Lopez-Andres, Krister Bamberg, Frederic Jaisser, Frederic Jaisser   +10 more
doaj   +1 more source

Comparative analysis of virtual screening approaches in the search for novel EphA2 receptor antagonists [PDF]

, 2015
The EphA2 receptor and its ephrin-A1 ligand form a key cell communication system, which has been found overexpressed in many cancer types and involved in tumor growth.
PALA, Daniele, Callegari, Donatella, Scalvini, Laura, Mor, Marco, Lodola, Alessio, Donatella Callegari, Pala, Daniela, Incerti, Matteo, Rivara, Silvia, Daniele Pala, Tognolini, Massimiliano, Marco Mor, Massimiliano Tognolini, Laura Scalvini, Matteo Incerti, Silvia Rivara, Alessio Lodola   +16 more
core   +1 more source

Heart failure: the role for mineralocorticoid receptor antagonists

Swiss Medical Weekly, 2014
Mineralocorticoid receptor antagonists (MRA’s) have been shown to be effective in patients with HFREF while their role in patients with HFPEF remains controversial. Despite a class  one indication in both the ESC and AHA/ACC heart failure guidelines
Bertram Pitt
doaj   +1 more source

Mineralocorticoid Receptor Antagonists-A New Sprinkle of Salt and Youth

, 2016
Skin atrophy and impaired cutaneous wound healing are the recognized side effects of topical glucocorticoid (GC) therapy. Although GCs have high affinity for the glucocorticoid receptor, they also bind and activate the mineralocorticoid receptor.
Stojadinovic, Olivera, Jozic, Ivan, Lindley, Linsey E, Tomic Canic, Marjana   +3 more
core   +2 more sources

Mineralocorticoid receptor antagonists reduce inflammatory signaling independent of myofiber mineralocorticoid receptor

Endocrine and Metabolic Science
Chronic inflammation is a feature of Duchenne muscular dystrophy (DMD), a degenerative striated muscle disease. Mineralocorticoid receptor (MR) antagonists (MRAs) have demonstrated clinical benefit on later onset DMD cardiomyopathy, and preclinical ...
Jeovanna Lowe, Arden B. Piepho, Chetan K. Gomatam, Peyton Debell, Megan N. Ballinger, Jill A. Rafael-Fortney   +5 more
doaj   +1 more source

Regulation of Klotho Production by Mineralocorticoid Receptor Signaling in Renal Cell Lines

Biomolecules
Through the mineralocorticoid receptor, aldosterone controls extracellular volume and arterial blood pressure by stimulating Na+ absorption and K+ secretion in epithelial cells of the kidney, colon, and several glands.
Elena Kohm, Martina Feger, Michael Föller   +2 more
doaj   +1 more source

Clinical impact of mineralocorticoid receptor antagonists treatment after acute coronary syndrome in the real world: A propensity score matching analysis [PDF]

, 2019
BACKGROUND: Recent studies suggest that the benefit of mineralocorticoid receptor antagonists in the acute coronary syndrome setting is controversial.
Rodríguez Mañero, Moises, Álvarez Rodríguez, Leyre, AGRA BERMEJO, ROSA MARIA, CID ALVAREZ, ANA BELEN, Cordero, A., Martínez Gómez, Álvaro, ABOU JOKH CASAS, CHARIGAN, González Juanatey, José Ramón, Álvarez Álvarez, Belén, García Acuña, José María   +9 more
core   +1 more source