Results 51 to 60 of about 1,419,720 (263)

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

AGING MEDICINE, EarlyView.
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley   +1 more source

Aldosterone: mechanisms of normal and impaired regulation and the possibility of their correction in arterial hypertension. Consensus of Russian Medical Society on Arterial Hypertension (RSH) experts

Терапевтический архив
In recent years, studies have been carried out that have expanded the understanding of the role of pathophysiological mechanisms underlying impaired regulation of aldosterone and activation of mineralocorticoid receptors in arterial hypertension. The aim
Novella M. Chikhladze, Nataliya V. Blinova, Olga Iu. Trushina, Valery I. Podzolkov, Anna E. Bragina, Irina E. Chazova   +5 more
doaj   +1 more source

Efficacy of low-dose spironolactone on top of angiotensin receptor blockade in patients with glomerulonephritis

Kidney Research and Clinical Practice, 2018
Background: Previous studies have shown that aldosterone antagonists have a proteinuria-lowering effect in patients with proteinuria and progressive proteinuric disease not adequately controlled by the use of angiotensin receptor blockers (ARBs ...
Byung Chul Yu, Min Sung Lee, Jong Joo Moon, Soo Jeong Choi, Jin Kuk Kim, Seung Duk Hwang, Moo Yong Park   +6 more
doaj   +1 more source

Hypertension in obesity: A focus on individualized pharmacotherapy and the role of body composition, on behalf of the European Society of Hypertension Working Group on Diabetes and Metabolic Risk Factors and Working Group on Lifestyle, Cardiovascular Pharmacotherapy and Adherence

British Journal of Clinical Pharmacology, EarlyView.
Hypertension in obesity represents a major global health challenge, closely linked to the global epidemics of obesity, type 2 diabetes and metabolic dysfunction. Excess adiposity contributes to elevated blood pressure through multiple, interrelated mechanisms, including activation of the renin–angiotensin–aldosterone system, sympathetic nervous system ...
Christina Antza, Andrej Belancic, Jens Jordan, Alberto Esteban, Anna Oliveras, Ryan McNally, Panagiota Anyfanti, Jorie Versmissen, María S. Fernández‐Alfonso, Vasilios Kotsis, Thomas Weber, Alexandre Persu, Reinhold Kreutz   +12 more
wiley   +1 more source

Design, synthesis, and evaluation of naphthalidinamide analogues as nonsteroidal mineralocorticoid receptor antagonists

Journal of Chemical Research
Inappropriate overactivation of the mineralocorticoid receptor by the steroid hormones aldosterone or cortisol contributes to the development of cardiovascular diseases.
Mingguang Zhang, Yan Pang, Yurui Zhao, Sibei Chen, Cheng Guo   +4 more
doaj   +1 more source

Evidence for Aldosterone Antagonism in Heart Failure

Cardiac Failure Review
Activation of the renin–angiotensin–aldosterone system is the ultimate pathophysiological hallmark in heart failure. Though aldosterone primarily appears to regulate electrolyte homeostasis by acting on distal nephrons in the kidneys, its effects are far-
Rishi Sethi, Pravesh Vishwakarma, Akshyaya Pradhan   +2 more
doaj   +1 more source

Cytoskeleton–Membrane Uncoupling in Duchenne Muscular Dystrophy: Implications for Newborn Screening and Early Protection

Cytoskeleton, EarlyView.
ABSTRACT The cytoskeleton of striated muscle integrates force transmission, mechanotransduction, and sarcolemmal stability through coordinated networks of sarcomeres, costameres, and intermediate filaments. Together, these systems establish mechanical continuity between the contractile apparatus, the sarcolemma, and the extracellular matrix.
Houda Cohen, Nora Hosny, Brian R. Thompson, Joseph M. Metzger   +3 more
wiley   +1 more source

Efficacy and Safety of Mineralocorticoid Receptor Antagonists in Patients with Heart Failure with Preserved Ejection Fraction: A Systematic Review

Efficacy and Safety of Mineralocorticoid Receptor Antagonists in Patients with Heart Failure with Preserved Ejection Fraction: A Systematic ...
Lídia Ana Zytinsky Moura, Ricardo Mourilhe Rocha, Diretrizes SBC, Silvia Marinho Martins, Denilson Campos de Albuquerque, Marcus Vinicius Simões, Fabiana G. Marcondes Braga, Luis Claudio Danzmann, Mucio Tavares de Oliveira-Júnior, José Albuquerque de Figueiredo-Neto   +9 more
core   +2 more sources

The impact of new tetralogy drugs on ventricular remodeling in heart failure patients: a systematic review and network meta-analysis

BMC Cardiovascular Disorders
Background Heart failure, particularly heart failure with reduced ejection fraction (HFrEF), represents a major global health challenge due to its high prevalence, rapid progression, and substantial mortality rates.
Xi-Wen Wang, Hao Li, Gan-Qi Wang, Ya-Nan Sheng, Xia Wang, Hui Pan, Zhi-Hao Wang, Wei Zhang, Yuan-Yuan Shang, Ming Zhong   +9 more
doaj   +1 more source

Discontinuation of Heart Failure Pharmacotherapy in Older Adults With Frailty

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Guideline‐directed medical therapy (GDMT) improves outcomes in heart failure irrespective of frailty status. Nevertheless, the magnitude of frailty‐associated discontinuation of GDMT remains insufficiently studied.
Ryo Nakamaru, Shiori Nishimura, Hiraku Kumamaru, Kyohei Daigo, Kayo M. Walsh, Shun Kohsaka   +5 more
doaj   +1 more source