Results 41 to 50 of about 1,285,117 (188)

Persistent hypoaldosteronism post-adrenalectomy for primary aldosteronism – a role for pre-operative spironolactone?

Endocrinology, Diabetes & Metabolism Case Reports, 2021
Primary aldosteronism is one of the most common (affecting up to 10%) yet treatable causes of hypertension in our community, notable due to an associated elevated risk of atrial fibrillation, stroke and myocardial infarction compared to essential ...
Lachlan M Angus, Jun Yang, Ada S Cheung
doaj   +1 more source

Mineralocorticoid receptor antagonists

, 2007
With an increasingly aging population, the need for effective treatment of cardiovascular diseases (eg, heart failure, hypertension, and ischemic heart disease) cannot be overemphasized.
Parthasarathy, Hari Krishnan, MacDonald, Thomas M.   +1 more
core   +1 more source

Network meta-analysis of mineralocorticoid receptor antagonists for diabetic kidney disease

Frontiers in Pharmacology, 2022
Diabetic kidney disease (DKD) is one of the major causes of end-stage renal disease (ESRD). To evaluate the efficacy and safety of different types of mineralocorticoid receptor antagonists (MRAs) in diabetic kidney disease patients, we conducted this ...
Yichuan Wu, Yichuan Wu, Huanjia Lin, Huanjia Lin, Yuan Tao, Yuan Tao, Ying Xu, Ying Xu, Jiaqi Chen, Jiaqi Chen, Yijie Jia, Yijie Jia, Zongji Zheng, Zongji Zheng   +13 more
doaj   +1 more source

Perioperative uses of histamine antagonists [PDF]

, 1990
Histamine release and adverse pseudoallergic/allergic reactions during the perioperative period occur frequently. The incidence of such reactions is 20%-30% for all grades of severity, 1%-5% for systemic reactions, and 0.1%-0.5% for life-threatening ...
Lorenz, Wilfried, Doenicke, A., Ennis, M., Dick, W.   +3 more
core   +1 more source

Acute Kidney Injury After Mechanical Thrombectomy for Stroke in Patients With Pre‐Existing Renal Impairment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Acute kidney injury (AKI) is a common but often underrecognized complication in ischemic stroke patients undergoing mechanical thrombectomy, particularly among those with pre‐existing renal impairment. This study evaluated the incidence, risk factors, and clinical impact of AKI in this high‐risk population.
Michał Borończyk, Marcel Pilarek, Emilia Jaworska, Natalia Kardas, Oliwia Barnaś, Julia Woźniak, Iga Machała, Julia Węgrzynek‐Gallina, Joanna Siuda, Anna Hawrot‐Kawecka, Anetta Lasek‐Bal   +10 more
wiley   +1 more source

MINERALOCORTICOID RECEPTOR ANTAGONISTS THERAPY IN RESISTANT HYPERTENSION: TIME TO IMPLEMENT NEW GUIDELINES?

Frontiers in Cardiovascular Medicine, 2015
Despite the availability of anti-hypertensive medications with increasing efficacy up to 50% of hypertensive patients have blood pressure levels (BP) not at the goals set by international societies.
Giuseppe eMaiolino, Matteo eAzzolini, Gian Paolo eRossi   +2 more
doaj   +1 more source

Mineralocorticoid receptor antagonists: The evolution of utility and pharmacology [PDF]

, 2000
Mineralocorticoid receptor antagonists: The evolution of utility and pharmacology. For more than 30 years after the discovery of aldosterone, scientists believed that its sole site of action was at epithelial tissues, most notably the kidney, where it ...
Delyani, John A.
core   +1 more source

SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho Deficiency

Advanced Science, EarlyView.
Klotho deficiency promotes podocyte mitochondrial dysfunction and ferroptosis through activation of the PKCα/CUX1/SPARC/TGFβ‐RII axis. SPARC emerges as a key mediator linking Klotho loss to podocyte injury in DKD and other kidney injury models, suggesting broader implications for CKD progression.
Qing Yang, Huimin Jiang, Chenyang Xiong, Xindi Zhou, Qinqin Tan, Han Xiao, Lan Qiu, Chun Gan, Yaxi Chen, Haiping Yang, Wei Jiang, Qiu Li   +11 more
wiley   +1 more source

Eplerenone in the Treatment of Polypoidal Choroidal Vasculopathy

Case Reports in Ophthalmology, 2015
Overactivation of mineralocorticoid receptor pathways has been implicated in the pathophysiology of central serous chorioretinopathy (CSCR). Recently, mineralocorticoid receptor antagonists such as eplerenone have demonstrated success in treating ...
Kapil G. Kapoor, Alan L. Wagner
doaj   +1 more source

Efficacy and Safety of Mineralocorticoid Receptor Antagonists in Kidney Failure Patients Treated with Dialysis: A Systematic Review and Meta-Analysis

, 2021
BACKGROUND AND OBJECTIVES: Patients with kidney failure have a high risk of cardiovascular disease due to cardiac remodeling, left ventricular fibrosis, and hyperaldosteronism, all of which can be potentially mitigated by mineralocorticoid receptor ...
Mai-Szu Wu, Kao, Chih-Chin, Kang, Yi-No, Tsai, I-Lin, Chih-Chin Kao, Chen, Kuan-Ting, Wu, Mai-Szu, Yen-Chung Lin, Yi-No Kang, Kuan-Ting Chen, Wei-Chiao Chang, Lin, Yen-Chung, Chang, Wei-Chiao, I-Lin Tsai, Fang, Te-Chao, Te-Chao Fang   +15 more
core   +1 more source