Results 51 to 60 of about 77,468 (262)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

CONSERVACIÓN DE MANGO TOMMY ATKINS MÍNIMAMENTE PROCESADO MEDIANTE LA APLICACIÓN DE UN RECUBRIMIENTO DE ALOE VERA (Aloe barbadensis MILLER)

Vitae
Antecedentes: El mango es una fruta climatérica que puede ver limitada su comercialización debido a la deficiencia en sistemas de procesamiento y conservación que ocasionan pérdidas poscosecha en la cadena agroindustrial.
Andrés F PÉREZ T, Iván D ARISTIZÁBAL T, Jorge I RESTREPO F   +2 more
doaj   +1 more source

Avaliação da qualidade microbiológica de frutos minimamente processados comercializados em supermercados de Fortaleza Evaluation of microbiological quality of fruits minimally processed commercialized in supermarkets in Fortaleza

Revista Brasileira de Fruticultura, 2005
O processamento mínimo tem sido descrito como a manipulação, o preparo, embalagem e a distribuição de produtos agrícolas, através de procedimentos como seleção, limpeza, lavagem, descascamento e corte, que não afetem suas características organolépticas ...
Neuma Maria de Souza Pinheiro, Evânia Altina Teixeira de Figueiredo, Raimundo Wilane de Figueiredo, Geraldo Arraes Maia, Paulo Henrique Machado de Souza   +4 more
doaj   +1 more source

The residues of fruit and vegetable processing: from "waste" to "resource" of natural phytochemical compounds

Advances in Horticultural Science, 2020
The project of Sant’Anna School, in line with the Italian legislation on limiting waste and promoting the redistribution of surpluses and unused goods, aimed to study the potential healthy value of residues obtained from the transformation of fruit and ...
Susanna Bartolini, M. Orlando, Alice Trivellini, F. Venturi, C. Sanmartin, I. Taglieri, M. Macaluso, A. Zinnai, Anna Mensuali-Sodi   +8 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Efeito da temperatura no armazenamento de uvas apirênicas minimamente processadas Effect of stored temperature in minimally processed seedless table grapes

Revista Brasileira de Fruticultura, 2009
O trabalho teve como objetivo avaliar a qualidade pós-colheita de três cultivares de uvas de mesa sem semente submetidas ao processamento mínimo e armazenadas sob refrigeração e à temperatura ambiente. Para tanto, foram utilizadas uvas das cultivares BRS
Ben-Hur Mattiuz, Ana Carolina Almeida Miguel, Vanessa Cury Galati, Jair Costa Nachtigal   +3 more
doaj   +1 more source