Results 101 to 110 of about 39,772 (266)

SWIM: A computational tool to unveiling crucial nodes in complex biological networks [PDF]

, 2017
SWItchMiner (SWIM) is a wizard-like software implementation of a procedure, previously described, able to extract information contained in complex networks.
Colombo, Teresa, Farina, Lorenzo, Fiscon, Giulia, Gurtner, Aymone, Paci, Paola, Pavesi, Giulio   +5 more
core   +2 more sources

Clinically relevant HIF-1α-dependent metabolic reprogramming in oropharyngeal squamous cell carcinomas includes coordinated activation of CAIX and the miR-210/ISCU signaling axis, but not MCT1 and MCT4 upregulation

OncoTarget, 2017
Metabolic reprogramming is a very heterogeneous phenomenon in cancer. It mostly consists on increased glycolysis, lactic acid formation and extracellular acidification.
Inés Saénz-de-Santa-María, Cristóbal Bernardo-Castiñeira, P. Secades, Sandra Bernaldo-de-Quirós, J. Rodrigo, A. Astudillo, M. Chiara   +6 more
semanticscholar   +1 more source

Clinical Impact of NOTCH3 Variant Location After First Stroke in CADASIL

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Despite its monogenic origin, Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy exhibits marked variability in clinical expression and severity. Variants in the NOTCH3 gene, within epidermal growth factor‐like repeat domains 1–6 or 7–34, are known to influence disease onset, but their impact ...
Léa Aguilhon, Hugues Chabriat, Dominique Hervé, Stéphanie Guey, Sophie Tezenas Du Montcel, Juliette Ortholand   +5 more
wiley   +1 more source

MicroRNA expression profiles in human CD3+ T cells following stimulation with anti‑human CD3 antibodies [PDF]

, 2017
Background: Anti-CD3 therapy can induce immunosuppression by several non mutually exclusive mechanisms that have been proposed to explain the therapeutic effect the administration anti-CD3 mAb, but its immunoregulatory mechanism is still not completely ...
Almo, Manuela Maragno do, Andrade, Rosângela Vieira, Bezerra, Maryani Andressa Gomes, Brígido, Marcelo de Macedo, Maranhão, Andréa Queiroz, Simi, Kelly Cristina Rodrigues, Sousa, Isabel Garcia   +6 more
core   +2 more sources

miR‐210 as a therapeutic target in diabetes‐associated endothelial dysfunction

British Journal of Pharmacology
MicroRNA (miR)‐210 function in endothelial cells and its role in diabetes‐associated endothelial dysfunction are not fully understood. We aimed to characterize the miR‐210 function in endothelial cells and study its therapeutic potential in diabetes.
Aida Collado, T. Jiao, E. Kontidou, Lucas Carvalho, E. Chernogubova, Jiangning Yang, G. Zaccagnini, A. Zhao, J. Tengbom, Xiaowei Zheng, B. Réthi, M. Alvarsson, S. Catrina, A. Mahdi, M. Carlström, F. Martelli, J. Pernow, Zhichao Zhou   +17 more
semanticscholar   +1 more source

Exosome-mediated targeted delivery of miR-210 for angiogenic therapy after cerebral ischemia in mice

Journal of Nanobiotechnology, 2019
BackgroundAccumulating evidence shows that microRNA-210 (miR-210) holds great promise to improve angiogenesis for brain tissue repair after cerebral ischemia.
Hui-xin Zhang, Jin Wu, Jiahua Wu, Q. Fan, Jingchao Zhou, Junwen Wu, Sichen Liu, J. Zang, Jinhai Ye, Ming Xiao, Tian Tian, Jun Gao   +11 more
semanticscholar   +1 more source

Sex Differences in Medication Discontinuation in Axial Spondyloarthritis

Arthritis Care &Research, EarlyView.
Objective We examined sex differences in medication discontinuation among patients with axial spondyloarthritis (axSpA) initiating tumor necrosis factor inhibitors (TNFi), interleukin‐17 inhibitors (IL‐17i), or JAK inhibitors (JAKi). Methods Using data from the Rheumatology Informatics System for Effectiveness (RISE) Registry (2003–2025), we assessed ...
Rachael Stovall, Cinthia Blat, Eric Roberts, Jean W. Liew, Katherine Wysham, Namrata Singh, Janna Friedly, Lianne S. Gensler, Gabriela Schmajuk, Jinoos Yazdany   +9 more
wiley   +1 more source

Oncogenic miR-210-3p promotes prostate cancer cell EMT and bone metastasis via NF-κB signaling pathway

Molecular Cancer, 2017
Background The primary issue arising from prostate cancer (PCa) is its high prevalence to metastasize to bone, which severely affects the quality of life and survival time of PCa patients.
Dong Ren, Qing Yang, Yuhu Dai, Wei Guo, Hong Du, Libing Song, Xinsheng Peng   +6 more
doaj   +1 more source

miR-210-3p suppresses osteogenic differentiation of MC3T3-E1 by targeting brain derived neurotrophic factor (BDNF)

Journal of Orthopaedic Surgery and Research, 2022
Background and objective As an important mediator of intercellular interaction and formation of extracellular bone matrix, porous scaffolds are widely used for bone regeneration.
Li Deng, Shuang Lai, Liyuan Fan, Xinlun Li, Hao Huang, Yandong Mu   +5 more
doaj   +1 more source

Radiological evaluation of biomarkers for renal cell carcinoma [PDF]

, 2018
Role of MRI DWI sequences in the evaluation of early response to neo- angiogenesis inhibitors in metastatic renal cell carcinoma Purpose: Angiogenesis inhibitors have a potential role in treating metastatic renal cell carcinoma, but it is still not ...
Marigliano, Chiara
core   +1 more source