Results 81 to 90 of about 39,772 (266)

Pregnancy-associated cardiac dysfunction and the regulatory role of microRNAs. [PDF]

, 2020
Many crucial cardiovascular adaptations occur in the body during pregnancy to ensure successful gestation. Maladaptation of the cardiovascular system during pregnancy can lead to complications that promote cardiac dysfunction and may lead to heart ...
Aryan, Laila, Eghbali, Mansoureh, Medzikovic, Lejla, Umar, Soban   +3 more
core  

Downregulation of miR-210-3p Attenuates High Glucose-Induced Angiogenesis of Vascular Endothelial Cells via Targeting FGFRL1

Ophthalmic Research, 2023
Introduction: Vascular endothelial cell injury and angiogenesis induced by hyperglycemia are the main pathological basis of vascular complications in diabetes mellitus.
Tao Wen, Yiwen Hong, Yamei Cui, Jianying Pan, Yishen Wang, Yan Luo   +5 more
semanticscholar   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

MicroRNA‐210 Promotes Accumulation of Neural Precursor Cells Around Ischemic Foci After Cerebral Ischemia by Regulating the SOCS1–STAT3–VEGF‐C Pathway

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundNeural precursor cell (NPC) migration toward lesions is key for neurological functional recovery. The neovasculature plays an important role in guiding NPC migration.
Zhao‐You Meng, Hua‐Li Kang, Wei Duan, Jian Zheng, Qian‐Ning Li, Zhu‐Juan Zhou   +5 more
doaj   +1 more source

Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif [PDF]

, 2013
MicroRNAs modulate tumorigenesis through suppression of specific genes. As many tumour types rely on overlapping oncogenic pathways, a core set of microRNAs may exist, which consistently drives or suppresses tumorigenesis in many cancer types.
Coarfa, Cristian, Ding, Li, Gunaratne, Preethi H., Hamilton, Mark P., Hartig, Sean M., Kandoth, Cyriac, McGuire, Sean E., McLellan, Michael D., Rajapakshe, Kimal, Reva, Boris, Wheeler, David A., Zack, Travis I.   +11 more
core   +3 more sources

Hypoxia-challenged MSC-derived exosomes deliver miR-210 to attenuate post-infarction cardiac apoptosis

Stem cell research & therapeutics, 2020
Background Myocardial infarction (MI) is a major cause of death worldwide. Although percutaneous coronary intervention and coronary artery bypass grafting can prolong life, cardiac damage persists.
Hao Cheng, Shufu Chang, Rende Xu, Lu Chen, Xiaoyue Song, Jian Wu, J. Qian, Y. Zou, Jianying Ma   +8 more
semanticscholar   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Induction of microRNAs, mir-155, mir-222, mir-424 and mir-503, promotes monocytic differentiation through combinatorial regulation [PDF]

, 2010
Acute myeloid leukemia (AML) involves a block in terminal differentiation of the myeloid lineage and uncontrolled proliferation of a progenitor state. Using phorbol myristate acetate (PMA), it is possible to overcome this block in THP-1 cells (an M5-AML ...
A Astrinidis, A Cimmino, A Pession, A Rosa, AD Basso, AW O’Sullivan, BP Lewis, C Esau, C Kanellopoulou, C le Sage, D Gaidatzis, D Liu, D O’Carroll, E Bernstein, E Gottwein, FO Martinez, GA Calin, GA Calin, GK Smyth, H Hohjoh, H Suzuki, H Tazawa, HY Chang, J Kluiver, J Severin, JF Chen, K Kitagawa, K Nie, L Fontana, M Selbach, MD Odero, N Felli, N Standart, PS Linsley, Q Liu, Q Wang, R Edgar, R Medina, R Visone, RJ Mayoral, RJ Taft, RW Georgantas 3rd, S Costinean, S Kang, S Tsuchiya, S Tsuchiya, T Beissbarth, V Martino, W Wang, Y Hayashita, Y Mizuno, YS Lee   +51 more
core   +2 more sources

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Various levels of circulating exosomal total-miRNA and miR-210 hypoxamiR in different forms of pregnancy hypertension [PDF]

, 2017
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Alasztics, Bálint, Biró, Orsolya, Joó, József Gábor, Molvarec, Attila, Nagy, Bálint, Rigó, János   +5 more
core   +1 more source