Results 11 to 20 of about 36,419 (163)

miR-210 loss leads to widespread phenotypic and gene expression changes in human 293T cells [PDF]

Frontiers in Genetics
IntroductionHypoxia responses are critical for myriad physiological and pathological processes, such as development, tissue repair, would healing, and tumorigenesis.
Xiaoxiao Zhang, Zhen Meng, Chengyong Yang, Chenghao Wang, Kexin Zhang, Anxin Shi, Jingjing Guo, Yong Feng, Yan Zeng   +8 more
doaj   +2 more sources

miR-210 overexpression increases pressure overload-induced cardiac fibrosis [PDF]

Non-coding RNA Research
Aortic stenosis, a common valvular heart disease, can lead to left ventricular pressure overload, triggering pro-fibrotic responses in the heart. miR-210 is a microRNA that responds to hypoxia and ischemia and plays a role in immune regulation and in ...
G. Zaccagnini, D. Baci, S. Tastsoglou, I. Cozza, A. Madè, C. Voellenkle, M. Nicoletti, C. Ruatti, M. Longo, L. Perani, C. Gaetano, A. Esposito, F. Martelli   +12 more
doaj   +2 more sources

Exercise-Induced miR-210 Promotes Cardiomyocyte Proliferation and Survival and Mediates Exercise-Induced Cardiac Protection against Ischemia/Reperfusion Injury [PDF]

Research
Exercise can stimulate physiological cardiac growth and provide cardioprotection effect in ischemia/reperfusion (I/R) injury. MiR-210 is regulated in the adaptation process induced by exercise; however, its impact on exercise-induced physiological ...
Yihua Bei, Hongyun Wang, Yang Liu, Zhuhua Su, Xinpeng Li, Yujiao Zhu, Ziyi Zhang, Mingming Yin, Chen Chen, Lin Li, Meng Wei, Xiangmin Meng, Xuchun Liang, Zhenzhen Huang, Richard Yang Cao, Lei Wang, Guoping Li, Dragos Cretoiu, Junjie Xiao   +18 more
doaj   +2 more sources

miR-210 is essential to retinal homeostasis in fruit flies and mice [PDF]

Biol Direct
Background miR-210 is one of the most evolutionarily conserved microRNAs. It is known to be involved in several physiological and pathological processes, including response to hypoxia, angiogenesis, cardiovascular diseases and cancer. Recently, new roles
Bertolucci C., Colaianni D., Cusumano P., De Pittà C., Maccarone R., Martelli F., Mazzone M., Preda M. B., Sales G., Stefanelli C., Taverna D., Tisi A., Virga F., Zaccagnini G.   +13 more
core   +2 more sources

Elevation of Circulating miR-210 Participates in the Occurrence and Development of Type 2 Diabetes Mellitus and Its Complications [PDF]

Journal of Diabetes Research, 2022
Objective. Circulating miRNAs are acclaimed biomarkers to predict the occurrence and progression of type 2 diabetes mellitus (T2DM). This study is aimed at analyzing the correlation of circulating miR-210 level and obesity-associated T2DM and then ...
Xi Chen, Feng Tian, Zhilian Sun, Guoqing Zeng, Ping Tang   +4 more
doaj   +2 more sources

Hypoxia‐induced miR‐210‐3p expression in lung adenocarcinoma potentiates tumor development by regulating CCL2 mediated monocyte infiltration [PDF]

Molecular Oncology
In most cancers, tumor hypoxia downregulates the expression of C‐C motif chemokine 2 (CCL2), and this downregulation has been implicated in monocyte infiltration and tumor progression; however, the molecular mechanism is not yet clear.
Leena Arora, Debarun Patra, Soumyajit Roy, Sidhanta Nanda, Navneet Singh, Anita K. Verma, Anuradha Chakraborti, Suman Dasgupta, Durba Pal   +8 more
doaj   +2 more sources

Study on the mechanism and clinical value of miR-210-3p and miR-582-5p in acute myocardial infarction by targeting MXD1 [PDF]

Journal of Cardiothoracic Surgery
Background Acute myocardial infarction (AMI) occurs rapidly and is a major cause of death in patients with coronary artery disease (CAD). To explore new biomarkers of AMI and its pathogenesis.
Shanshan Liu, Jing Han, Shufang Gao
doaj   +2 more sources

miR-210 promotes the anti-inflammatory phenotype and M2 polarization in murine macrophages [PDF]

Frontiers in Immunology
IntroductionMacrophages play fundamental roles in immune regulation and tissue homeostasis, serving as one of the primary cell types that orchestrate tissue repair after injury.
Carmen Alexandra Neculachi, Evelyn-Gabriela Nastase-Rusu, Laudy Cherry, Catalina Iolanda Marinescu-Colan, Spyros Tastsoglou, Bogdan Paul Cosman, Alina Madalina Popa, Cristina Panciuc, Germana Zaccagnini, Germana Zaccagnini, Sergiu Bogdan Catrina, Sergiu Bogdan Catrina, Maya Simionescu, Fabio Martelli, Fabio Martelli, Mihai Bogdan Preda, Alexandrina Burlacu   +16 more
doaj   +2 more sources

miR-210-3p protects against osteoarthritis through inhibiting subchondral angiogenesis by targeting the expression of TGFBR1 and ID4 [PDF]

Frontiers in Immunology, 2022
Excessive subchondral angiogenesis is a key pathological feature of osteoarthritis (OA), as it alters the balance of subchondral bone remodeling and causes progressive cartilage degradation.
Han Tang, Wenrun Zhu, Lu Cao, Jin Zhang, Juncheng Li, Duan Ma, Changan Guo   +6 more
doaj   +2 more sources

miR-210 Mediated Hypoxic Responses in Pancreatic Ductal Adenocarcinoma [PDF]

ACS Omega
Pancreatic ductal adenocarcinoma (PDAC) is one among the most lethal malignancies due to its aggressive behavior and resistance to conventional therapies.
Dart, DA, Lian, M, Miralles, F, Mortoglou, M, Uysal-Onganer, P   +4 more
core   +2 more sources