Results 41 to 50 of about 39,772 (266)

Small extracellular vesicles derived from hypoxic mesenchymal stem cells promote vascularized bone regeneration through the miR-210-3p/EFNA3/PI3K pathway.

Acta Biomaterialia, 2022
Angiogenesis is closely coupled with osteogenesis and has equal importance. Thus, promoting angiogenesis during the bone repair process is vital for ideal bone regeneration.
Yu Zhuang, M. Cheng, Meng Li, Jinjie Cui, Jinyang Huang, Chenglong Zhang, Jiawen Si, Kaili Lin, Hongbo Yu   +8 more
semanticscholar   +1 more source

Inhibition of microRNA-210 provides neuroprotection in hypoxic–ischemic brain injury in neonatal rats

Neurobiology of Disease, 2016
Perinatal hypoxic–ischemic encephalopathy (HIE) is associated with high neonatal mortality and severe long-term neurologic morbidity. Yet the mechanisms of brain injury in infants with HIE remain largely elusive.
Qingyi Ma, Chiranjib Dasgupta, Yong Li, Nikita M. Bajwa, Fuxia Xiong, Benjamin Harding, Richard Hartman, Lubo Zhang   +7 more
doaj   +1 more source

Secreted miR-210-3p as non-invasive biomarker in clear cell renal cell carcinoma [PDF]

, 2017
The most common subtype of renal cell carcinoma (RCC) is clear cell RCC (ccRCC). It accounts for 70-80% of all renal malignancies representing the third most common urological cancer after prostate and bladder cancer.
Carbone, Antonio, Costantini, Manuela, DI CARLO, Angelina, Fazi, Francesco, Gallucci, Michele, Marigliano, Chiara, Palleschi, Giovanni, Pastore, ANTONIO LUIGI, Petrozza, Vincenzo, Porta, Natale, Ricci, Serena, Simone, Giuseppe, Tito, Claudia   +12 more
core   +2 more sources

Dual Scaffold Delivery of miR-210 Mimic and miR-16 Inhibitor Enhances Angiogenesis and Osteogenesis to Accelerate Bone Healing.

Acta Biomaterialia, 2023
Angiogenesis is critical for successful bone repair, and interestingly, miR-210 and miR-16 possess counter-active targets involved in both angiogenesis and osteogenesis: miR-210 acts as an activator by silencing EFNA3 & AcvR1b, while miR-16 inhibits both
Irene Mencía Castaño, R. Raftery, Gang Chen, B. Cavanagh, Brian Quinn, G. Duffy, C. Curtin, F. O’Brien   +7 more
semanticscholar   +1 more source

miR-210: More than a silent player in hypoxi [PDF]

, 2011
Multiple studies have consistently established that miR (microRNA)-210 induction is a feature of the hypoxic response in both normal and transformed cells.
Devlin, Cecilia, Greco, Simona, Ivan, Mircea, Martelli, Fabio   +3 more
core   +1 more source

HIF-1α Stabilization Increases miR-210 Eliciting First Trimester Extravillous Trophoblast Mitochondrial Dysfunction

Frontiers in Physiology, 2019
Preeclampsia is associated with first trimester placental dysfunction. miR-210, a small non-coding RNA, is increased in the preeclamptic placenta. The effects of elevated miR-210 on placental function remain unclear.
Lauren Anton, Ann DeVine, Erzsebet Polyak, Anthony Olarerin-George, Amy G. Brown, Marni J. Falk, Michal A. Elovitz   +6 more
doaj   +1 more source

Dysregulation of miR-210 is involved in the development of diabetic retinopathy and serves a regulatory role in retinal vascular endothelial cell proliferation

European Journal of Medical Research, 2020
Background Diabetic retinopathy is a common complication of diabetes mellitus (DM). The purpose of this study was to investigate the expression and clinical significance of miR-210 in DR patients and explore the regulatory effect of miR-210 on vascular ...
Chengyu Yin, Xiangqiang Lin, Yafei Sun, Xinli Ji   +3 more
doaj   +1 more source

miR-210: fine-tuning the hypoxic response [PDF]

, 2014
Hypoxia is a central component of the tumor microenvironment and represents a major source of therapeutic failure in cancer therapy. Recent work has provided a wealth of evidence that noncoding RNAs and, in particular, microRNAs, are significant members ...
A Allegra, A Giannakakis, A Hüttenhofer, A Krek, A Shinohara, A Ventura, A Zhao, AC Koong, AE Pasquinelli, AM Cheng, AS Ho, B Malzkorn, B Wightman, BE Baysal, BJ Reinhart, BL Pineles, BP Lewis, BP Lewis, C Camps, C Devlin, C Nakada, C-C Chio, CH Lawrie, D Baek, D Betel, D Gou, D Hanahan, D Juan, DA Enquobahrie, DA Landau, DD Taylor, DP Bartel, DP Bartel, DS Schwarz, E Balsa, E Bostjancic, E Fabbri, E Fabbri, E Favaro, E Gottlieb, E Miko, E Rooij van, EJ Jung, F Mochel, F Rothe, F Wu, FE Benson, FV Karginov, G Leone, G Meroni, G Wan, GA Calin, GL Semenza, GL Semenza, GL Semenza, GL Semenza, GL Wang, GL Wang, GL Wang, H Antonicka, H Guo, H Iguchi, H Valadi, H Zhang, H-Y Chen, HE Gee, HW Kim, HW Kim, HW King, I Satzger, J Brugarolas, J He, J Lu, J Sarkar, J Stenvang, J Tabernero, J Wang, JA Foekens, JA Lees, JA Weber, JC Presti Jr, JC Venter, JD Gordan, JM Brown, JR Gnarra, JW Kim, K Jeyaseelan, K Pulkkinen, K Ruan, KP Porkka, L Cicchillitti, L Hong, L Qin, L Salmena, LP Lim, M Ivan, M Kertesz, M Liu, M Maragkakis, M Raponi, M Redova, M Selbach, MA Alaiti, MA Cortez, MA Valencia-Sanchez, ME Crosby, MP Murphy, MP Puissegur, MV Iorio, MV Iorio, MZ Michael, N Bushati, N Yanaihara, NC Denko, NC Denko, NL Simone, NMA White, O Bunoust, P Fasanaro, P Fasanaro, P Fasanaro, P Jaakkola, P Vaupel, PJ Hurlin, PS Mitchell, R Bindra, R Faraonio, R Gambari, R Garzon, R Kulshreshtha, R Kulshreshtha, RA Gatenby, RB Donker, RC Lee, RD Guzy, RE Lanford, RF Place, RK Mutharasan, S Biswas, S Djebali, S Djuranovic, S Djuranovic, S Gilad, S Greco, S Griffiths-Jones, S Hammer, S Hu, S Krick, S Kuijper, S Tsuchiya, S Vasudevan, S Wang, SA Ciafre, SY Chan, T Greither, T Greither, T Kawamata, T Li, T Thum, T Toyama, TJ Kelly, W Yang, W Zundel, WH Tong, WR Wilson, X Chen, X Huang, X Huang, X Zhang, XM Zhu, Y Lee, Y Lee, Y Liu, Y Liu, Y Mizuno, Y Murakami, Y Nakamura, Y Nie, YL Lou, Z Chen, Z Zhang   +180 more
core   +1 more source

MicroRNA-210 and endoplasmic reticulum chaperones in the regulation of chemoresistance in glioblastoma [PDF]

, 2015
Glioblastoma multiforme (GBM) is the commonest primary brain tumour in adults characterized by relentless recurrence due to resistance towards the standard chemotherapeutic agent temozolomide (TMZ).
Fung, CF, Ho, ASW, Kiang, KMY, Lee, D, Leung, GKK, Lui, WM, Sun, S, Zhang, PD, Zhang, XQ   +8 more
core   +1 more source

MicroRNA-210 induces apoptosis in colorectal cancer via induction of reactive oxygen [PDF]

, 2016
Additional file 2: Figure S2. Representative flow cytometric histograms of CRC cell lines 72 h post transfection with pre-miR-210 and a control miRNA, respectively.
Anne Fassl, Jutta Richter, Katrin E. Tagscherer, Sabrina Schecher, Stephan Macher-Goeppinger, Tabea Sinkovic, Wilfried Roth   +6 more
core   +4 more sources