Journal of Nanobiotechnology, 2023 Background Spinal cord injury (SCI) remains a significant health concern, with limited available treatment options. This condition poses significant medical, economic, and social challenges.
Peng Gao +13 more
semanticscholar +1 more source
Macrophage miR-210 induction and metabolic reprogramming in response to pathogen interaction boost life-threatening inflammation [PDF]
, 2021 Unbalanced immune responses to pathogens can be life-threatening although the underlying regulatory mechanisms remain unknown. Here, we show a hypoxia-inducible factor 1α-dependent microRNA (miR)-210 up-regulation in monocytes and macrophages upon ...
Cappellesso F. +27 more
core +8 more sources
Frontiers in Molecular Neuroscience, 2018 Vascular dementia (VD) is the most common form of dementia in elderly people. However, little is understood about the role of microRNAs (miRNAs) involved in cognitive impairment in early VD. Here, a VD model induced by chronic cerebral ischemia and fetal
Zhenxing Ren +8 more
doaj +1 more source
Down-regulation of TIMP2 by HIF-1α/miR-210/HIF-3α regulatory feedback circuit enhances cancer metastasis in hepatocellular carcinoma [PDF]
, 2016 Cancer metastasis is a multistep process that involves a series of tumor-stromal interaction, including extracellular matrix (ECM) remodeling, which requires a concerted action of multiple proteolytic enzymes and their endogenous inhibitors.
Chan, LK +6 more
core +1 more source
Hypoxia-Induced MicroRNA-210 Targets Neurodegenerative Pathways
Non-Coding RNA, 2018 Hypoxia-regulated microRNA-210 (miR-210) is a highly conserved microRNA, known to regulate various processes under hypoxic conditions. Previously we found that miR-210 is also involved in honeybee learning and memory, raising the questions of how neural ...
Michelle E. Watts +3 more
doaj +1 more source
Serum miR-210 Contributes to Tumor Detection, Stage Prediction and Dynamic Surveillance in Patients with Bladder Cancer. [PDF]
PLoS ONE, 2015 MiR-210 is the master hypoxamir that generally exhibits oncogenic properties in most human solid tumors including bladder cancer (BC). However, it remains unknown about the clinical significance of circulating miR-210 levels in BC.
Yongmei Yang +13 more
doaj +1 more source
MicroRNA response to hypoxic stress in soft tissue sarcoma cells: MicroRNA mediated regulation of HIF3α [PDF]
, 2014 Background: Hypoxia is often encountered in solid tumors and known to contribute to aggressive tumor behavior, radiation- and chemotherapy resistance resulting in a poor prognosis for the cancer patient.
Gits, C.M.M. (Caroline) +9 more
core +1 more source
TLR3-induced placental miR-210 down-regulates the STAT6/interleukin-4 pathway. [PDF]
PLoS ONE, 2013 Several clinical studies have reported increased placental miR-210 expression in women with PE compared to normotensive women, but whether miR-210 plays a role in the etiology of PE is unknown.
Shelley E Kopriva +3 more
doaj +1 more source
Experimental Gerontology, 2023 The differentiation of human induced pluripotent stem cells (hiPSCs) into functional dopaminergic neural precursors is the basis of cell therapy for Parkinson's disease (PD). However, the use of small molecule inhibitors/activators in the differentiation
Y. Lyu +9 more
semanticscholar +1 more source
miR-210 controls the evening phase of circadian locomotor rhythms through repression of Fasciclin 2.
PLoS Genetics, 2019 Circadian clocks control the timing of animal behavioral and physiological rhythms. Fruit flies anticipate daily environmental changes and exhibit two peaks of locomotor activity around dawn and dusk.
Ye Niu +4 more
doaj +1 more source