Results 11 to 20 of about 39,772 (266)

miR-210 promotes hepatocellular carcinoma progression by modulating macrophage autophagy through PI3K/AKT/mTOR signaling. [PDF]

Biochem Biophys Res Commun, 2023
Background: Tumor-associated macrophages (TAMs) play an important role in tumor development. Increasing research suggests that miR-210 may promote the progression of tumor virulence, but whether its pro-carcinogenic effect in primary hepatocellular ...
Bi S, Zhang Y, Zhou J, Yao Y, Wang J, Fang M, Li B, Wu C, Ren C.   +8 more
europepmc   +2 more sources

miR-210 loss leads to widespread phenotypic and gene expression changes in human 293T cells [PDF]

Frontiers in Genetics
IntroductionHypoxia responses are critical for myriad physiological and pathological processes, such as development, tissue repair, would healing, and tumorigenesis.
Xiaoxiao Zhang, Zhen Meng, Chengyong Yang, Chenghao Wang, Kexin Zhang, Anxin Shi, Jingjing Guo, Yong Feng, Yan Zeng   +8 more
doaj   +2 more sources

Hypoxia-preconditioned WJ-MSC spheroid-derived exosomes delivering miR-210 for renal cell restoration in hypoxia-reoxygenation injury. [PDF]

Stem Cell Res Ther
Recent advancements in mesenchymal stem cell (MSC) technology have paved the way for innovative treatment options for various diseases. These stem cells play a crucial role in tissue regeneration and repair, releasing local anti-inflammatory and healing ...
Toghiani R, Azimian Zavareh V, Najafi H, Mirian M, Azarpira N, Abolmaali SS, Varshosaz J, Tamaddon AM.   +7 more
europepmc   +2 more sources

miR-210-3p enriched extracellular vesicles from hypoxic neuroblastoma cells stimulate migration and invasion of target cells. [PDF]

Cell Biosci, 2023
Background Tumor hypoxia stimulates release of extracellular vesicles (EVs) that facilitate short- and long-range intercellular communication and metastatization. Albeit hypoxia and EVs release are known features of Neuroblastoma (NB), a metastasis-prone
Fusco P, Fietta A, Esposito MR, Zanella L, Micheli S, Bastianello A, Bova L, Borile G, Germano G, Cimetta E.   +9 more
europepmc   +2 more sources

miR-210 overexpression increases pressure overload-induced cardiac fibrosis [PDF]

Non-coding RNA Research
Aortic stenosis, a common valvular heart disease, can lead to left ventricular pressure overload, triggering pro-fibrotic responses in the heart. miR-210 is a microRNA that responds to hypoxia and ischemia and plays a role in immune regulation and in ...
G. Zaccagnini, D. Baci, S. Tastsoglou, I. Cozza, A. Madè, C. Voellenkle, M. Nicoletti, C. Ruatti, M. Longo, L. Perani, C. Gaetano, A. Esposito, F. Martelli   +12 more
doaj   +2 more sources

NF-κB factors cooperate with Su(Hw)/E4F1 to balance Drosophila/human immune responses via modulating dynamic expression of miR-210. [PDF]

Nucleic Acids Res
MicroRNAs (miRNAs) play crucial regulatory roles in controlling immune responses, but their dynamic expression mechanisms are poorly understood. Here, we firstly confirm that the conserved miRNA miR-210 negatively regulates innate immune responses of ...
Zhou H, Huang Y, Jia C, Pang Y, Liu L, Xu Y, Jin P, Qian J, Ma F.   +8 more
europepmc   +2 more sources

CPEB2 Suppresses Hepatocellular Carcinoma Epithelial-Mesenchymal Transition and Metastasis through Regulating the HIF-1α/miR-210-3p/CPEB2 Axis. [PDF]

Pharmaceutics, 2023
Hepatocellular carcinoma (HCC) is a prevalent and high-mortality cancer worldwide, and its complexity necessitates novel strategies for drug selection and design.
You R, Yang Y, Yin G, Jiang H, Lu Y, Gui L, Bao J, Xu Q, Feng L.   +8 more
europepmc   +2 more sources

ALDH5A1/miR-210 axis plays a key role in reprogramming cellular metabolism and has a significant correlation with glioblastoma patient survival. [PDF]

Cancer Cell Int
Glioblastoma (GBM) is the most aggressive among the tumors of the central nervous system (CNS), and has a dismal prognosis. Altered metabolism, especially the increased rate of aerobic glycolysis promotes rapid proliferation of GBM cells.
Mondal I, Gupta N, Sharma V, Sarkar C, Mishra DP, Kulshreshtha R.   +5 more
europepmc   +2 more sources

Hypoxia Regulates Brown Adipocyte Differentiation and Stimulates miR-210 by HIF-1α. [PDF]

Int J Mol Sci
MicroRNAs (miRNAs) are short sequences of single-stranded non-coding RNAs that target messenger RNAs, leading to their repression or decay. Interestingly, miRNAs play a role in the cellular response to low oxygen levels, known as hypoxia, which is ...
Caca J, Bartelt A, Egea V.
europepmc   +2 more sources

Genetic and hypoxic alterations of the microRNA‐210‐ISCU1/2 axis promote iron–sulfur deficiency and pulmonary hypertension [PDF]

EMBO Molecular Medicine, 2015
Iron–sulfur (Fe‐S) clusters are essential for mitochondrial metabolism, but their regulation in pulmonary hypertension (PH) remains enigmatic. We demonstrate that alterations of the miR‐210‐ISCU1/2 axis cause Fe‐S deficiencies in vivo and promote PH.
Kevin White, Yu Lu, Sofia Annis, Andrew E Hale, B Nelson Chau, James E Dahlman, Craig Hemann, Alexander R Opotowsky, Sara O Vargas, Ivan Rosas, Mark A Perrella, Juan C Osorio, Kathleen J Haley, Brian B Graham, Rahul Kumar, Rajan Saggar, Rajeev Saggar, W Dean Wallace, David J Ross, Omar F Khan, Andrew Bader, Bernadette R Gochuico, Majed Matar, Kevin Polach, Nicolai M Johannessen, Haydn M Prosser, Daniel G Anderson, Robert Langer, Jay L Zweier, Laurence A Bindoff, David Systrom, Aaron B Waxman, Richard C Jin, Stephen Y Chan   +33 more
doaj   +2 more sources