Results 51 to 60 of about 482,752 (300)

Analysis of differential expression of hypoxia-inducible microRNA-210 gene targets in mild and severe preeclamptic patients

Non-coding RNA Research, 2021
Preeclampsia (PE) is a multi-system disorder that is specific to human pregnancy. Inadequate oxygenation of uterus and placenta is considered as one of the leading causes for the disease.
Deeba S. Jairajpuri, Zainab H. Malalla, Sameh Sarray, Naeema Mahmood   +3 more
doaj   +1 more source

miR-210 locus deletion disrupts cellular homeostasis: an integrated genetic study. [PDF]

Sci Rep
AbstractMiR-210 is widely recognized as the quintessential hypoxia-responsive miRNA and thought to fine-tune various facets of cellular homeostasis. We hereby present an integrative appraisal of phenotypic and molecular repercussions of disrupting the corresponding locus in human and mouse cells using multiple genetic strategies.
Preda MB, Nastase-Rusu EG, Neculachi CA, Zhong X, Voellenkle C, Mazure NM, Balacescu O, Ivan C, Zheng XW, Gherghiceanu M, Lebrigand K, Simionescu M, Martelli F, Mari B, Catrina SB, Burlacu A, Ivan M.   +16 more
europepmc   +2 more sources

Plasma extracellular vesicle delivery of miR-210-3p by targeting ATG7 to promote sepsis-induced acute lung injury by regulating autophagy and activating inflammation

Experimental and Molecular Medicine, 2021
Extracellular vesicles (EVs) can be used for intercellular communication by facilitating the transfer of miRNAs from one cell to a recipient cell. MicroRNA (miR)-210-3p is released into the blood during sepsis, inducing cytokine production and promoting ...
Guang Li, Bo Wang, Xiang-chao Ding, Xinghua Zhang, Jian Tang, Hui-Qing Lin   +5 more
semanticscholar   +1 more source

HIF-1α Stabilization Increases miR-210 Eliciting First Trimester Extravillous Trophoblast Mitochondrial Dysfunction

Frontiers in Physiology, 2019
Preeclampsia is associated with first trimester placental dysfunction. miR-210, a small non-coding RNA, is increased in the preeclamptic placenta. The effects of elevated miR-210 on placental function remain unclear.
Lauren Anton, Ann DeVine, Erzsebet Polyak, Anthony Olarerin-George, Amy G. Brown, Marni J. Falk, Michal A. Elovitz   +6 more
doaj   +1 more source

Dysregulation of miR-210 is involved in the development of diabetic retinopathy and serves a regulatory role in retinal vascular endothelial cell proliferation

European Journal of Medical Research, 2020
Background Diabetic retinopathy is a common complication of diabetes mellitus (DM). The purpose of this study was to investigate the expression and clinical significance of miR-210 in DR patients and explore the regulatory effect of miR-210 on vascular ...
Chengyu Yin, Xiangqiang Lin, Yafei Sun, Xinli Ji   +3 more
doaj   +1 more source

Hypoxia-challenged MSC-derived exosomes deliver miR-210 to attenuate post-infarction cardiac apoptosis

Stem cell research & therapeutics, 2020
Background Myocardial infarction (MI) is a major cause of death worldwide. Although percutaneous coronary intervention and coronary artery bypass grafting can prolong life, cardiac damage persists.
Hao Cheng, Shufu Chang, Rende Xu, Lu Chen, Xiaoyue Song, Jian Wu, J. Qian, Y. Zou, Jianying Ma   +8 more
semanticscholar   +1 more source

PLC-beta 1 regulates the expression of miR-210 during mithramycin-mediated erythroid differentiation in K562 cells [PDF]

, 2014
PLC-beta 1 (PLCβ1) inhibits in human K562 cells erythroid differentiation induced by mithramycin (MTH) by targeting miR-210 expression. Inhibition of miR-210 affects the erythroid differentiation pathway and it occurs to a greater extent in MTH-treated ...
Bavelloni, Alberto, Blalock, William, Cocco, Lucio, Faenza, Irene, Fiume, Roberta, Matteucci, Alessandro, McCubrey, James A., NC DOCKS at East Carolina University, Poli, Alessandro, Ramazzotti, Giulia   +9 more
core   +2 more sources

MicroRNA-210 induces apoptosis in colorectal cancer via induction of reactive oxygen [PDF]

, 2016
Additional file 2: Figure S2. Representative flow cytometric histograms of CRC cell lines 72 h post transfection with pre-miR-210 and a control miRNA, respectively.
Anne Fassl, Jutta Richter, Katrin E. Tagscherer, Sabrina Schecher, Stephan Macher-Goeppinger, Tabea Sinkovic, Wilfried Roth   +6 more
core   +4 more sources

Nickel nanoparticle-induced cell transformation: involvement of DNA damage and DNA repair defect through HIF-1α/miR-210/Rad52 pathway

Journal of Nanobiotechnology, 2021
Background Nickel nanoparticles (Nano-Ni) are increasingly used in industry and biomedicine with the development of nanotechnology. However, the genotoxic and carcinogenic effects of Nano-Ni and the underlying mechanisms are still unclear.
Y. Mo, Yue Zhang, Yuanbao Zhang, Jiali Yuan, Lu-jiao Mo, Qunwei Zhang   +5 more
semanticscholar   +1 more source

MicroRNA-210 and endoplasmic reticulum chaperones in the regulation of chemoresistance in glioblastoma [PDF]

, 2015
Glioblastoma multiforme (GBM) is the commonest primary brain tumour in adults characterized by relentless recurrence due to resistance towards the standard chemotherapeutic agent temozolomide (TMZ).
Fung, CF, Ho, ASW, Kiang, KMY, Lee, D, Leung, GKK, Lui, WM, Sun, S, Zhang, PD, Zhang, XQ   +8 more
core   +1 more source