Results 11 to 20 of about 70 (69)

miR-370-3p Regulates Adipogenesis through Targeting Mknk1 [PDF]

Molecules, 2021
Excessive fat accumulation can lead to obesity, diabetes, hyperlipidemia, atherosclerosis, and other diseases. MicroRNAs are a class of microRNAs that regulate gene expression and are highly conserved in function among species. microRNAs have been shown to act as regulatory factors to inhibit fat accumulation in the body.
Peiwen Zhang, Xinrong Li, Shunhua Zhang, Shuang Wu, Qian Xiao, Yang Gu, Xinyu Guo, Xutao Lin, Lei Chen, Ye Zhao, Lili Niu, Guoqing Tang, Yanzhi Jiang, Linyuan Shen, Li Zhu   +14 more
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circITGA7 Acts As miR-370-3p Sponge to Suppress The Proliferation of Prostate Cancer [PDF]

Journal of Oncology, 2021
Abstract Objective: Prostate cancer (PCa) refers to one of the most common tumors in male’s genitourinary system. Emerging research has confirmed that circRNAs play an important role in the occurrence and development of tumors. However, the correlation between circular RNA circITGA7 and PCa still remains unclear.
Gang Luo, Guohao Li, Zhihua Wan, Yuanjie Zhang, Dong Liu, Yonglian Guo   +5 more
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miR-370-3p as a Novel Biomarker Promotes Breast Cancer Progression by Targeting FBLN5 [PDF]

Stem Cells International, 2021
miRNAs play a crucial part in multiple biological processes of cell proliferation, migration, apoptosis, and chemoresistance. In cancer, miRNAs can be divided into oncogenes or tumor suppressors on the basis of their functions in the carcinogenic process.
Jiahui Mao, Lingxia Wang, Junying Wu, Yichun Wang, Huiyan Wen, Xueming Zhu, Bo Wang, Huan Yang   +7 more
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Chi-miR-370-3p regulates hair follicle morphogenesis of Inner Mongolian cashmere goats [PDF]

G3 Genes|Genomes|Genetics, 2021
Abstract MicroRNAs (miRNAs), a class of 22 nucleotide (nt) noncoding RNAs, negatively regulate mRNA posttranscriptional modification in various biological processes. Morphogenesis of skin hair follicles in cashmere goats is a dynamic process involving many key signaling molecules, but the associated cellular biological mechanisms induced
Erhan Hai, Wenjing Han, Zhihong Wu, Rong Ma, Fangzheng Shang, Min Wang, Lili Liang, Youjun Rong, Jianfeng Pan, Zhiying Wang, Ruijun Wang, Rui Su, Yanhong Zhao, Zhihong Liu, Zhixin Wang, Jinquan Li, Yanjun Zhang   +16 more
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Inhibition of intervertebral disc disease progression via the circPKNOX1–miR-370-3p–KIAA0355 axis [PDF]

Cell Death Discovery, 2021
AbstractThe molecular mechanism underlying the development of intervertebral disc disease (IVDD) is not completely understood. Circular RNAs (circRNAs) play a significant role in the occurrence and development of various diseases, and studies have shown that circPKNOX1 is involved in the compensatory response of extracellular matrix synthesis and ...
Yizhen Huang, Jun Gao, Jianle Wang, Huali Ye, Teng Yao, Yining Xu, Zizheng Chen, Shuying Shen, Jianjun Ma   +8 more
openaire   +3 more sources

LncRNA NEAT1 mediates sepsis progression by regulating Irak2 via sponging miR-370-3p [PDF]

Biology Open, 2020
Background: Sepsis is a life-threatening condition and often associated with multiple organ failure. Nuclear-enriched abundant transcript 1 (NEAT1), a member of long non-coding RNAs (lncRNAs), was reported to be involved in the regulation of sepsis progression.
Ting Xiao, Chuihua Sun, Ying Xiao, Yunbao Li   +3 more
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Silencing miR-370-3p rescues funny current and sinus node function in heart failure [PDF]

Scientific Reports, 2020
AbstractBradyarrhythmias are an important cause of mortality in heart failure and previous studies indicate a mechanistic role for electrical remodelling of the key pacemaking ion channel HCN4 in this process. Here we show that, in a mouse model of heart failure in which there is sinus bradycardia, there is upregulation of a microRNA (miR-370-3p ...
Joseph Yanni, Alicia D’Souza, Yanwen Wang, Ning Li, Brian J. Hansen, Stanislav O. Zakharkin, Matthew Smith, Christina Hayward, Bryan A. Whitson, Peter J. Mohler, Paul M. L. Janssen, Leo Zeef, Moinuddin Choudhury, Min Zi, Xue Cai, Sunil Jit R. J. Logantha, Shu Nakao, Andrew Atkinson, Maria Petkova, Ursula Doris, Jonathan Ariyaratnam, Elizabeth J. Cartwright, Sam Griffiths-Jones, George Hart, Vadim V. Fedorov, Delvac Oceandy, Halina Dobrzynski, Mark R. Boyett   +27 more
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Increased circulating miR-370-3p regulates steroidogenic factor 1 in endometriosis [PDF]

American Journal of Physiology-Endocrinology and Metabolism, 2019
Endometriosis is a gynecologic disease common among reproductive-aged women caused by the growth of endometrial tissue outside the uterus. Altered expression of numerous genes and microRNAs has been reported in endometriosis. Steroidogenic factor 1 (SF-1), an essential transcriptional regulator of multiple genes involved in estrogen biosynthesis, is ...
Zhuoying, Hu, Ramanaiah, Mamillapalli, Hugh S, Taylor   +2 more
openaire   +2 more sources

Decrease of circARID1A retards glioblastoma invasion by modulating miR-370-3p/ TGFBR2 pathway

International Journal of Biological Sciences, 2022
Increasing evidence suggests that circular RNAs (circRNAs) are involved in regulating tumor biological activity. Glioblastoma (GBM) is one of the most lethal diseases characterized by highly aggressive proliferative and invasive behaviors. We aimed to explore how circRNAs influenced GBM biological activity.
Li, Baisheng, Chen, Jiansheng, Wu, Yi, Luo, Honghai, Ke, Yiquan   +4 more
openaire   +2 more sources

CircAGFG1 promotes cervical cancer progression via miR-370-3p/RAF1 signaling [PDF]

BMC Cancer, 2019
Abstract Background In past decades, circular RNAs (circRNAs) have achieved increasing attention because of its regulatory role in different kinds of cancers. However, how circAGFG1 regulates cervical cancer (CC) is still largely undiscovered. This study aims to evaluate the role of a novel circRNAs and related molecular mechanism in CC cells ...
Fengqin Wu, Jingjing Zhou
openaire   +3 more sources