Results 21 to 30 of about 70 (69)

MicroRNA hsa-miR-370-3p suppresses the expression and induction of CYP2D6 by facilitating mRNA degradation [PDF]

Biochemical Pharmacology, 2017
Cytochrome P450 2D6 (CYP2D6) participates in the metabolism of approximately 20-25% of prescribed drugs. Genetic polymorphisms influence the expression and/or activity of CYP2D6, and inter-individual differences in drug activation and elimination caused by CYP2D6 genetic variants were reported. However, little is known about the potential modulation of
Linjuan, Zeng, Yinting, Chen, Yong, Wang, Li-Rong, Yu, Bridgett, Knox, Jiwei, Chen, Tieliu, Shi, Si, Chen, Zhen, Ren, Lei, Guo, Yuanfeng, Wu, David, Liu, Kaihong, Huang, Weida, Tong, Dianke, Yu, Baitang, Ning   +15 more
openaire   +2 more sources

Wnt7a and miR-370-3p: new contributors to bladder cancer invasion

Biotarget, 2018
In eukaryotes, microRNAs (miRNAs) are central regulators of gene expression. These small noncoding RNAs are about 19–24 nucleotides long (1). miRNAs can silence gene expression by binding to a complementary sequence in the 3'-UTR of the target gene, which then triggers mRNA degradation.
Danielle, Scheunemann, Anjan K, Pradhan, Swadesh K, Das, Devanand, Sarkar, Luni, Emdad, Paul B, Fisher   +5 more
openaire   +2 more sources

LncMyoD Promotes Skeletal Myogenesis and Regulates Skeletal Muscle Fiber-Type Composition by Sponging miR-370-3p [PDF]

Genes, 2021
The development of skeletal muscle is a highly ordered and complex biological process. Increasing evidence has shown that noncoding RNAs, especially long-noncoding RNAs (lncRNAs) and microRNAs, play a vital role in the development of myogenic processes.
Peiwen Zhang, Jingjing Du, Xinyu Guo, Shuang Wu, Jin He, Xinrong Li, Linyuan Shen, Lei Chen, Bohong Li, Jingjun Zhang, Yuhao Xie, Lili Niu, Dongmei Jiang, Xuewei Li, Shunhua Zhang, Li Zhu   +15 more
openaire   +2 more sources

Up-regulation of miR-370-3p restores glioblastoma multiforme sensitivity to temozolomide by influencing MGMT expression [PDF]

Scientific Reports, 2016
AbstractMicroRNAs (miRNA) are believed to play an important role in glioblastoma multiforme (GBM)chemotherapy. Our study aims to investigate potential miRNA biomarkers in GBM. Sixty GBM patients, which were given temozolomide (TMZ) chemotherapy and recurrent radiotherapy, were recruited.
Yong-tao Gao, Xiao-bing Chen, Hong-lin Liu   +2 more
openaire   +2 more sources

lncRNA SNHG15 Promotes Ovarian Cancer Progression through Regulated CDK6 via Sponging miR‐370‐3p

BioMed Research International, 2021
Ovarian cancer is a kind of cancer from the female genital tract; the molecular mechanism still needs to be explored. lncRNA plays a vital role in tumorigenesis and development. Our aim was to identify oncogenic lncRNAs in ovarian cancer and explore the potential molecular mechanism.
Yi Wang, Minghong Ding, Xiaoqing Yuan, Ruibao Jiao, Dagao Zhu, Wanzhong Huang, Wenxia Deng, Yulong Liu   +7 more
openaire   +2 more sources

miR-370-3p Is a Therapeutic Tool in Anti-glioblastoma Therapy but Is Not an Intratumoral or Cell-free Circulating Biomarker [PDF]

Molecular Therapy Nucleic Acids, 2018
In the last decade, microRNAs (miRs) have been described as biomarkers and therapeutic agents. Based on this finding, our aim here is to know if (1) miRNA-370-3p can be used as a biomarker associated with a favorable survival and if (2) miRNA-370-3p can be used as a therapeutic tool that increases the efficiency of standard anti-GBM treatment.
Nadaradjane, Arulraj, Briand, Joséphine, Bougras-Cartron, Gwenola, Disdero, Valentine, Vallette, François, Frenel, Jean-Sébastien, Cartron, Pierre-François   +6 more
openaire   +5 more sources

circ_0023461 Silencing Protects Cardiomyocytes from Hypoxia‐Induced Dysfunction through Targeting miR‐370‐3p/PDE4D Signaling [PDF]

Oxidative Medicine and Cellular Longevity, 2021
Background. Acute myocardial infarction (AMI) is a common cardiovascular disease with high disability and mortality. Circular RNAs (circRNAs) are implicated in the pathomechanism of multiple human diseases, including AMI. This study intended to explore the function and working mechanism of a novel circRNA circ_0023461 in hypoxia‐induced cardiomyocytes.
Kai Ren, Buying Li, Liqing Jiang, Zhiheng Liu, Fan Wu, Yi Zhang, Jincheng Liu, Weixun Duan   +7 more
openaire   +2 more sources

Myc-mediated circular RNA circMcph1/miR-370-3p/Irak2 axis is a progressive regulator in hepatic fibrosis

Life Sciences, 2023
Treating hepatic fibrosis (HF) is a major challenge worldwide. However, the biological functions and regulatory mechanisms of circular RNAs (circRNAs) remain unclear in HF. The present study aimed to elucidate the novel role of circMcph1 in HF.HF mouse model was established by injecting CCl4 intraperitoneally and validated using hematoxylin and eosin ...
Jin-Jin, Xu, Xin, Chen, Sai, Zhu, Ling-Feng, Jiang, Wen-Xian, Ma, Si-Yu, Chen, Xiao-Ming, Meng, Cheng, Huang, Jun, Li   +8 more
openaire   +2 more sources

Circ_0010729 knockdown protects cardiomyocytes against hypoxic dysfunction via miR-370-3p/TRAF6 axis

EXCLI journal, 2020
EXCLI Journal; 19:Doc1520; ISSN 1611 ...
Zhang, Jingjing, Gao, Chuanyu, Zhang, Jing, Ye, Famin   +3 more
openaire   +3 more sources

lncRNA BCAR4 sponges miR‑370‑3p to promote bladder cancer progression via Wnt signaling

International Journal of Molecular Medicine, 2019
Accumulating evidence suggests that the aberrant expression of long non‑coding RNAs (lncRNAs) is involved in the initiation, development and metastasis of bladder cancer (BC). Although several differentially expressed lncRNAs have been identified via lncRNA expression profiling of BC tissues, their functions and the molecular mechanisms underlying ...
Zhang, Rongkui, Wang, Jiping, Jia, Er'na, Zhang, Jialiang, Liu, Nan, Chi, Changliang   +5 more
openaire   +3 more sources